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인간배아줄기세포로부터 간세포로의 유도 분화를 이용한 간질환 세포 치료의 최근 연구 동향
Directed Differentiation of Human Embryonic Stem cells into Transplantable Hepatocytes: Recent Progress and Future Directions

우동훈   (고려대학교 생명과학대학 생명공학부  ); 김종훈   (고려대학교 생명과학대학 생명공학부  );
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  • 참고문헌 (32)

    1. Rambhatla L, Chiu C, Kundu P, Peng Y, Carpenter MK. Generation of hepatocyte-like cells from human embryonic stem cells. Cell Transplant 2003; 12: 1-11 
    2. Baharvand H, Piryaei A, Rohani R, Taei A, Heidari MH, Hosseini A, et al. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int J Dev Biol 2006; 50: 645-52 
    3. Baharvand H, Hashemi SM, Shahsavani M. Differentiation of human embryonic stem cells into functional hepatocyte-like cells in a serum-free adherent culture condition. Differentiation 2008; 76: 465-77 
    4. Blyszczuk P, Czyz J, Kania G, Wagner M, Roll U, St-Onge L, et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulinproducing cells. Proc Natl Acad Sci U S A 2003; 100: 998-1003 
    5. Chowdhury JR, Grossman M, Gupta S, Chowdhury NR, Baker JR, Wilson JM. Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. Science 1991; 254: 1802-5 
    6. Gunsalus JR, Brady DA, Coulter SM, Gray BM, Edge AS. Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nat Med 1997; 3: 48-53 
    7. Cho SW, Moon SH, Lee SH, Kang SW, Kim J, Lim JM, et al. Improvement of postnatal neovascularization by human embryonic stem cell derived endothelial-like cell transplantation in a mouse model of hindlimb ischemia. Circulation 2007; 116: 2409-19 
    8. Lu P, Jones LL, Snyder EY, Tuszynski MH. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol 2003; 181: 115-29 
    9. Fraser SE, Harland RM, The molecular metamorphosis of experimental embryology. Cell 2000; 100: 41-55 
    10. Habibullah CM, Syed IH, Qamar A, Taher-Uz Z. Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994; 58: 951-2 
    11. Basma H, Soto-Gutierrez A, Yannam GR, Ito R, Yamamoto T, Ellis E, et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology 2009; 136: 990-9 
    12. Hay DC, Zhao D, Fletcher J, Hewitt ZA, McLean D, Urruticoechea-Uriguen A, et al. Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo. Stem Cells 2008; 26: 894-902 
    13. Lee WM. Acute liver failure. Am J Med 1994; 96: 3S-9S 
    14. Lake JR. Hepatocyte transplantation. N Engl J Med 1998; 338: 1463-5 
    15. Zhao D, Chen S, Cai J, Guo Y, Song Z, et al. Derivation and characterization of hepatic progenitor cells from human embryonic stem cells. PLoS One 2009; 4: e6468 
    16. Shirahashi H, Wu J, Yamamoto N, Catana A, Wege H, Wager B, et al. Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage. Cell Transplant 2004; 13: 197-211 
    17. D'Amour KA, Agulnic AD, Eliazer S, Kelly OG, Kroon E, Baetge EE. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005; 23: 1534-41 
    18. Lavon N, Yanuka O, Benvenisty N. Differentiation and isolation of hepatic-like cells from human embryonic stem cells. Differentiation 2004; 72: 230-8 
    19. Zaret KS. Regulatory phases of early liver development: paradigms of organogenesis. Nat Rev Genet 2002; 3: 499-512 
    20. Fox IJ, Chowdhury JR Kaufman SS Goertzen TC Chowdhury, NR, Warkentin PI, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 1998; 338: 1422-6 
    21. Formigli L, Perna AM, Meacci E, Cinci L, Margheri M, Nistri S. Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling. J Cell Mol Med 2007; 11: 1087-100 
    22. Lee WM. Drug-induced hepatotoxicity. N Engl J Med 1995; 333: 1118-27 
    23. Strom SC, Fisher RA, Thompson MT, Sanyal AJ, Cole PE, Ham JM, Posner MP. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 1997; 63: 559-69 
    24. Duan Y, Catana A, Meng Y, Yamamoto N, He S, Gupta S, et al. Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo. Stem Cells 2007; 25: 3058-68 
    25. Uemura R, Xu M, Ahmad N, Ashraf M, Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res 2006; 98: 1414-21 
    26. Wilson JM, Chowdhury NR, Grossman M, Wajsman R, Epstein A, Mulligan RC. Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes. Proc Natl Acad Sci U S A 1990; 87: 8437-41 
    27. Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, et al. Repopulation Efficiencies of Adult Hepatocytes, Fetal Liver Progenitor Cells, and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice. Am J Pathol 2009. Aug 28. [Epub ahead of print] 
    28. Cai J, Liu Y, Ye F, Song Z, Qin H, Meng S, et al. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 2007; 45: 1229-39 
    29. Fukuda H, Takahashi J, Watanabe K, Hayashi H, Morizane A, Koyanagi M, et al. Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells 2006; 24: 763-71 
    30. Hay DC, Fletcher J, Payne C, Terrace JD, Gallagher RC, Snoeys J, et al. Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Proc Natl Acad Sci U S A 2008; 105: 12301-6 
    31. Grossman M, Raper SE, Kozarsky K, Stein EA, Engelhardt JF, Muller D, et al. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet 1994; 6: 335-41 
    32. Hay DC, Zhao D, Ross A, Mandalam R, Lebkowski J, Cui W. Direct differentiation of human embryonic stem cells to hepatocyte-like cells exhibiting functional activities. Cloning Stem Cells 2007; 9: 51-62 

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