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약학회지 = Yakhak hoeji v.53 no.6, 2009년, pp.321 - 327  

Licochalcone A가 대식세포주의 사이토카인 생성에 미치는 영향
Effect of Licochalcone A on the Production of Cytokines in LPS-Activated RAW264.7 Macrophage Cells

이기세    (전남대학교 약학대학 & 약품개발연구소   ); 이성호    (전남대학교 약학대학 & 약품개발연구소   ); 조영창    (전남대학교 약학대학 & 약품개발연구소   ); 윤구    (강릉 한국과학기술연구원   ); 천승훈    (전남대학교 약학대학 & 약품개발연구소   ); 강복윤    (전남대학교 약학대학 & 약품개발연구소  );
  • 초록

    Licochalcone A is a chalcone isolated from the roots of Glycyrrhiza inflate. In this study, we examined the effects of licochalonce A on the production of cytokines in LPS-activated macrophages. Licochalcone A inhibited the secretion of proinflammatory cytokines such as IL-1 $\beta$ , IL-6, and TNF- $\alpha$ . The reduced secretion of proinflammatory cytokines is related to the differences in the mRNA expression of IL-1 $\beta$ , IL-6, and TNF- $\alpha$ . Moreover, licochalcone A inhibited the mRNA expression of IL-12p40, IL-18, and IL-23p19. To investigate its mechanism, we performed gel shift assay. Licochalcone A reduced nuclear NF- ${\kappa}B$ binding activity in LPS-activated RAW264.7 cells. Taken together, these results suggest that licochalcone A has anti-inflammatory effects in LPS-activated macrophages and its mechanism could be through the down-regulation of binding to the ${\kappa}B$ site.


  • 주제어

    licochalcone A .   macrophage .   inflammation .   cytokines.  

  • 참고문헌 (31)

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