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약학회지 = Yakhak hoeji v.53 no.5, 2009년, pp.250 - 258  

야콘 50% 에탄올 추출물의 성인 남성의 정자 수 증가효과
The Spermatogenic Effect of 50% Ethanol Extracts of Yacon in Healthy Male Volunteers

박정숙    (충북대학교 약학대학   ); 황석연    (대전대학교 응용산업대학   ); 한건    (충북대학교 약학대학  );
  • 초록

    Male reproductive function seems to have deteriorated considerably in the past 4 to 5 decades. It was observed a significant decline in mean sperm counts from $113{\times}10^6/ml$ in 1940 to $66{\times}10^6/ml$ in 1990; a fall of $0.94{\times}10^6/ml/year$ . We reported that Yacon tuber extracts have spermatogenic effects in rat. In the present study, we tested the spermatogenic effect of Yacon tuber extracts in healthy male volunteers. Subjects were assigned randomly to the control group and the Yacon ethanol extracts administered group (each 12 subjects). And, placebo or Yacon tuber extracts (100 ml) were administered two times daily, by oral for 3 months. Sperm numbers, biochemical parameters and hormone levels were recorded before starting administration, then every month. The Yacon tuber extracts administered group showed significant time dependant increases in according to administration period. Especially, the numbers of sperm increased by 54% after 3 months of administration. And, in Yacon tuber extracts administered group, testosterone and estradiol level were significantly higher than placebo group. On the other hands, Yacon tuber extracts didn't show any toxicity in glucose and lipid metabolism and liver and kidney function. The results of the present study suggest that Yacon tuber extract is a possible therapeutic for the treatment of sperm deficiency.


  • 주제어

    Yacon .   sperm .   spermatogenesis .   testosterone .   estradiol.  

  • 참고문헌 (10)

    1. World Health Organization. Recent advances in medically assisted conception. Technical report series no. 820. Cambridge University Press, New York (1995) 
    2. Aybar, M. J., Riera, A. N. S., Grau, A. and Sanchez, S. S. : Hypoglycemic effect of the water extract of Smallanthus sonchifolius (Yacon) leaves in normal and diabetic rats. J. Ethnopharm. 74, 125 (2001) 
    3. Yan, X., Suzuki, M., Ohnishi-Kameyama, M., Sada, Y., Nakanishi, T. and Nagata, T. : Extraction and identification of antioxidants in roots of yacon (Smallanthus sonchifolius). J. Agric. Food Chem. 47, 4711 (1999) 
    4. Park, J. S., Hwang, S. Y., Hwang, B. Y. and Han, K. : The spermatogenic effect of 50% ethanol extracts of Yacon and Its ameliorative effect against 2,3,7,8-tetrachlorodibenzo-p-dioxininducedtesticulartoxicityintherat. Nat. Prod. Sci. 14, 73 (2008)     
    5. Strasinger, S. K. and Di Lorenzo, M. S. : Urinalysis and Body Fluids, 5th Edition, F. A. Davis Company, p. 225 (2008) 
    6. 이종욱, 이성준, 이진무, 고성건, 채수응, 최황, 이은식 : 비뇨기과학, 도서출판 고려의학, 서울 p. 443 (1996) 
    7. Carlsen, E. L., Giwercmn, A. and Keiding, N. : Evidence for decreasing quality of semen during past 50 years. Br. Med. J. 305, 609 (1992) 
    8. Lachman, J., Fernandez, E. C. and Orsak M. : Yacon [Smallanthus sonchifolia (Poepp. et Endl.) H. Robinson] chemical composition and use - a review. Plant soil Environ. 49, 283 (2003) 
    9. Choi, J. S., Kim, I. W., Hwang, S. Y., Shin, B. J. and Kim, S. K. : Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on testicular spermatogenesis-related panels and serum sex hormone levels in rats. BJU Int. 101, 250 (2008) 
    10. Simonovska, B., Vovk, I., Andrenek, S., Valentov, K. and Ulrichov, J. : Investigation of phenolic acids in yacon (Smallanthus sonchifolius) leaves and tubers. J. Chromatography A 1016, 89 (2003) 

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