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The journal of advanced prosthodontics v.2 no.1, 2010년, pp.18 - 24   피인용횟수: 1

Effect of etched microgrooves on hydrophilicity of titanium and osteoblast responses: A pilot study

Park, Jung-Ae    (Department of Prosthodontics, Graduate School of Dentistry   ); Lee, Sung-Bok Richard    (Department of Biomaterials & Prosthodontics, East-West Neo Medical Center, Institute of Oral Biology, School of Dentistry, Kyung Hee University   ); Ahn, Su-Jin    (Department of Biomaterials & Prosthodontics, East-West Neo Medical Center, Institute of Oral Biology, School of Dentistry, Kyung Hee University   ); Lee, Suk-Won    (Department of Biomaterials & Prosthodontics, East-West Neo Medical Center, Institute of Oral Biology, School of Dentistry, Kyung Hee University  );
  • 초록

    PURPOSE. The aim of this pilot study was to investigate the effect of etched microgrooves on the hydrophilicity of Ti and osteoblast responses. MATERIAL AND METHODS. Microgrooves were applied on Ti to have 15 and $60{\mu}m$ width, and 3.5 and $10{\mu}m$ depth by photolithography, respectively. Further acid etching was applied to create Ti surfaces with etched microgrooves. Both smooth- and acid-etched Ti were used as the controls. The hydrophilicity of Ti was analyzed by determining contact angles. Cell proliferation and osteogenic activity of MC3T3 mouse preosteoblasts were analyzed by bromodeoxyuridine assay and alkaline phosphatase (ALP) activity test, respectively. One-way ANOVA, Pearson's correlation analysis and multiple regression analysis were used for statistics. RESULTS. Etched microgrooves significantly increased the hydrophilicity of Ti compared to the smooth Ti. $60{\mu}m$ -wide etched microgrooves significantly enhanced cell proliferation, whereas the osteogenic activity showed statistically non-significant differences between groups. Result of the osteogenic activity significantly correlated with those of hydrophilicity and cell proliferation. Hydrophilicity was determined to be an influential factor on osteogenic activity. CONCLUSION. This study indicates that increase in hydrophilicity of Ti caused by etched microgrooves acts as an influential factor on osteogenic activity. However, statistically non-significant increase in the ALP activity suggests further investigation.


  • 주제어

    Titanium .   Etched microgrooves .   Hydrophilicity .   Osteoblast response.  

  • 참고문헌 (18)

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  • 이 논문을 인용한 문헌 (1)

    1. 2015. "" The journal of advanced prosthodontics, 7(6): 496~505     

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