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Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.33 no.6, 2010년, pp.831 - 842   SCIE
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Synthesis and Preliminary Antibacterial Evaluation of 2-Butyl Succinate-based Hydroxamate Derivatives Containing Isoxazole Rings

Zhang, Datong    (School of Chemistry and Chemical Engineering, Shandong University   ); Jia, Jiong    (School of Chemistry and Chemical Engineering, Shandong University   ); Meng, Lijuan    (School of Chemistry and Chemical Engineering, Shandong University   ); Xu, Weiren    (Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research   ); Tang, Lida    (Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research   ); Wang, Jianwu    (School of Chemistry and Chemical Engineering, Shandong University  );
  • 초록

    Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcus aureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.


  • 주제어

    2-Butyl succinate-based hydroxamate derivatives .   Isoxazole .   Synthesis .   Antibacterial activity.  

  • 참고문헌 (27)

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