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Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.33 no.6, 2010년, pp.843 - 851   SCIE 피인용횟수: 6
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Atractylodes japonica Koidzumi Inhibits the Production of Proinflammatory Cytokines through Inhibition of the NF-$\kappa$B/I$\kappa$B Signal Pathway in HMC-1 Human Mast Cells

Hong, Myung-Hee    (Department of Preventive Medicine, College of Oriental Medicine, Kyunghee University   ); Kim, Jeong-Hyun    (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University   ); Bae, Hyun-Su    (Department of Physiology, College of Oriental Medicine, Kyunghee University   ); Lee, Na-Youn    (Purimed R&D Institute, Kyunghee University   ); Shin, Yong-Cheol    (Department of Preventive Medicine, College of Oriental Medicine, Kyunghee University   ); Kim, Sung-Hoon    (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University   ); Ko, Seong-Gyu    (Department of Preventive Medicine, College of Oriental Medicine, Kyunghee University  );
  • 초록

    The rhizome of Atractylodes japonica Koidzumi (AJK) has been used in traditional medicine for treatment of arthritis, bronchitis and respiratory infectious disease, whereas its effects on inflammatory reactions have not been unknown recently. In this study, the effects of AJK on allergic inflammation and its signaling were investigated in the induced human mast cells and animal model. This study showed that ethanol extract of AJK interestingly suppressed the production and mRNA expression of TNF- ${\alpha}$ , IL-6 and IL-8, as important inflammatory cytokines. Furthermore, AJK inhibited the nuclear translocation of nuclear factor (NF)- $\kappa$ B through inhibition of the phosphorylation of I $\kappa$ B- ${\alpha}$ , which was additionally elucidated by NF- $\kappa$ B promoter-mediated luciferase activity. In addition, the phosphorylation of ERK was increased in pretreatment with AJK, whereas there was no change in JNK and p38 MAPK. However, AJK showed no effects on anti-DNP IgE-mediated in vivo PCA reaction and histamine release, as key events of mast cell-mediated immediate allergic reactions. These results suggest that AJK might be involved in not early-phase but transition to late-phase reactions of allergic inflammation and could modulate through other signal pathways. Taken together, AJK could be used as a treatment for mast cell mediated late-phase/chronic allergic inflammatory reactions.


  • 주제어

    Atractylodes japonica Koidzumi .   Allergic inflammation .   Human mast cells .   NF- $\kappa$B .   Pro-inflammatory cytokine.  

  • 참고문헌 (30)

    1. Baldwin, A. S. Jr., The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol., 14, 649-683 (1996). 
    2. Bischoff, S. C., Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat. Rev. Immunol., 7, 93-104 (2007). 
    3. Choi, E. M., Kim, G. H., and Lee, Y. S., Atractylodes japonica root extract protects osteoblastic MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation. Phytother. Res., In press. 
    4. Choi, I. W., Kim, Y. S., Kim, D. K., Choi, J. H., Seo, K. H., Im, S. Y., Kwon, K. S., Lee, M. S., Ha, T. Y., and Lee, H. K., Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. J. Exp. Med., 198, 145-151 (2003). 
    5. Choi, I. W., Sun, K., Kim, Y. S., Ko, H. M., Im, S. Y., Kim, J. H., You, H. J., Lee, Y. C., Lee, J. H., Park, Y. M., and Lee, H. K., TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation. J. Allergy Clin. Immunol., 116, 537-543 (2005). 
    6. Collins, T. and Cybulsky, M. I., NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?. J. Clin. Invest., 107, 255-264 (2001). 
    7. Cruse, G., Kaur, D., Yang, W., Duffy, S. M., Brightling, C. E., and Bradding, P., Activation of human lung mast cells by monomeric immunoglobulin E. Eur. Respir. J., 25, 858-863 (2005). 
    8. Dong, H., He, L., Huang, M., and Dong, Y., Anti-inflammatory components isolated from Atractylodes macrocephala Koidz. Nat. Prod. Res., 22, 1418-1427 (2008). 
    9. Galli, S. J., Tsai, M., and Piliponsky, A. M., The development of allergic inflammation. Nature, 454, 445-454 (2008). 
    10. Gilfillan, A. M. and Tkaczyk, C., Integrated signalling pathways for mast-cell activation. Nat. Rev. Immunol., 6, 218-230 (2006). 
    11. Hachisuka, H., Kusuhara, M., Higuchi, M., Okubo, K., and Sasai, Y., Purification of rat cutaneous mast cells with Percoll density centrifugation. Arch. Dermatol. Res., 280, 358-362 (1988). 
    12. Harada, M., Nagata, M., and Takeuchi, M., Production of passive cutaneous anaphylaxis (PCA) and reversed PCA by rat IgE antibody in the mouse. Experientia, 44, 459-462 (1988). 
    13. Jobin, C., Bradham, C. A., Russo, M. P., Juma, B., Narula, A. S., Brenner, D. A., and Sartor, R. B., Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor Ikappa B kinase activity. J. Immunol., 163, 3474-3483 (1999). 
    14. Karin, M. and Ben-Neriah, Y., Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol., 18, 621-663 (2000). 
    15. Kim, S. J., Lee, E. J., Song, Y. S., Jeong, H. J., Lee, K. M., Kim, H. R., Chae, H. J., Shin, T. Y., Kim, Y. K., Hong, S. H., and Kim, H. M., Cheongyeolsaseuptang inhibits production of TNF-alpha, IL-6 and IL-8 as well as NF-kappa B activation in human mast cells. J. Ethnopharmacol., 97, 83-88 (2005). 
    16. Kyriakis, J. M. and Avruch, J., Sounding the alarm: protein kinase cascades activated by stress and inflammation. J. Biol. Chem., 271, 24313-24316 (1996). 
    17. Li, C. Q., He, L. C., and Jin, J. Q., Atractylenolide I and atractylenolide III inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages. Phytother. Res., 21, 347-353 (2007). 
    18. Lippert, U., Moller, A., Welker, P., Artuc, M., and Henz, B. M., Inhibition of cytokine secretion from human leukemic mast cells and basophils by H1- and H2-receptor antagonists. Exp. Dermatol., 9, 118-124 (2000). 
    19. Mekori, Y. A. and Metcalfe, D. D., Mast cells in innate immunity. Immunol. Rev., 173, 131-140 (2000). 
    20. Mican, J. A., Arora, N., Burd, P. R., and Metcalfe, D. D., Passive cutaneous anaphylaxis in mouse skin is associated with local accumulation of interleukin-6 mRNA and immunoreactive interleukin-6 protein. J. Allergy Clin. Immunol., 90, 815-824 (1992). 
    21. Prussin, C. and Metcalfe, D. D., 4. IgE, mast cells, basophils, and eosinophils. J. Allergy Clin. Immunol., 111, S486-S494 (2003). 
    22. Valenta, R., The future of antigen-specific immunotherapy of allergy. Nat. Rev. Immunol., 2, 446-453 (2002). 
    23. Wong, C. K., Tsang, C. M., Ip, W. K., and Lam, C. W., Molecular mechanisms for the release of chemokines from human leukemic mast cell line (HMC)-1 cells activated by SCF and TNF-alpha: roles of ERK, p38 MAPK, and NFkappaB. Allergy, 61, 289-297 (2006). 
    24. Wong, W. S. and Koh, D. S., Advances in immunopharmacology of asthma. Biochem. Pharmacol., 59, 1323-1335 (2000). 
    25. Yamamoto, Y., Yin, M. J., Lin, K. M., and Gaynor, R. B., Sulindac inhibits activation of the NF-kappaB pathway. J. Biol. Chem., 274, 27307-27314 (1999). 
    26. Duan, W. and Wong, W. S., Targeting mitogen-activated protein kinases for asthma. Curr. Drug Targets, 7, 691-698 (2006). 
    27. Han, S. B., Lee, C. W., Yoon, Y. D., Lee, J. H., Kang, J. S., Lee, K. H., Yoon, W. K., Lee, K., Park, S. K., and Kim, H. M., Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated from Achyranthes bidentata and Atractylodes japonica. Arch. Pharm. Res., 28, 902-908 (2005).     
    28. Jang, M. H., Shin, M. C., Kim, Y. J., Kim, C. J., Kim, Y., and Kim, E. H., Atractylodes japonica suppresses lipopolysaccharide-stimulated expressions of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 macrophages. Biol. Pharm. Bull., 27, 324-327 (2004). 
    29. Min, B. S., Kim, Y. H., Tomiyama, M., Nakamura, N., Miyashiro, H., Otake, T., and Hattori, M., Inhibitory effects of Korean plants on HIV-1 activities. Phytother. Res., 15, 481-486 (2001). 
    30. Satoh, K., Nagai, F., Ushiyama, K., and Kano, I., Specific inhibition of Na+,K(+)-ATPase activity by atractylon, a major component of byaku-jutsu, by interaction with enzyme in the E2 state. Biochem. Pharmacol., 51, 339-343 (1996). 
  • 이 논문을 인용한 문헌 (6)

    1. 2011. "" Oriental pharmacy and experimental medicine, 11(1): 71~76     
    2. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(2): 203~210     
    3. 2012. "" TANG [HUMANITAS MEDICINE]: International journal of genuine traditional medicine, 2(1): 9.1~9.13     
    4. Lim, Hyun ; Lee, Je Hyeong ; Kim, Jinwoong ; Kim, Yeong Shik ; Kim, Hyun Pyo 2012. "Effects of the Rhizomes of Atractylodes japonica and Atractylenolide I on Allergic Response and Experimental Atopic Dermatitis" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 35(11): 2007~2012     
    5. Park, Cheol ; Hong, Su Hyun ; Choi, Sung Hyun ; Lee, Se-Ra ; Leem, Sun-Hee ; Choi, Yung Hyun 2015. "Sagantang-induced Apoptotic Cell Death is Associated with the Activation of Caspases in AGS Human Gastric Carcinoma Cells" 생명과학회지 = Journal of life science, 25(12): 1384~1392     
    6. Bin, Chang-Hyun ; Song, Choon-Ho 2015. "Ameliorating Effects of Atractylodes macrocephala Koidzumi on TNF-α-induced 3T3-L1 Adipocyte Dysfunction" Korean journal of acupuncture, 32(3): 116~123     

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