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Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.33 no.6, 2010년, pp.863 - 866   SCIE 피인용횟수: 1
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Isolation of Virus-cell Fusion Inhibitory Components from the Stem Bark of Styrax japonica S. et Z.

Lee, Dung-Gun    (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University   ); Jin, Qinglong    (College of Pharmacy, Chosun University   ); Jin, Hong-Guang    (College of Pharmacy, Chosun University   ); Shin, Ji-Eun    (College of Pharmacy, Chosun University   ); Choi, Eun-Jin    (College of Pharmacy, Chosun University   ); Woo, Eun-Rhan    (College of Pharmacy, Chosun University  );
  • 초록

    Five compounds, styraxjaponoside A (1), matairesinoside (2), egonol glucoside (3), dihydrodehydrodiconiferyl alcohol 9'-O-glucoside (4), and styraxjaponoside B (5) were isolated from the stem bark of Styrax japonica. Among them, compounds 1 and 5 showed significantly high virus-cell fusion inhibitory activity. In addition, compound 5 exhibited almost equivalent virus-cell fusion inhibitory activity to that of dextran sulfate, which is used as a positive control.


  • 주제어

    Styrax japonica S.   et Z.   .   Virus-cell fusion .   Anti-HIV .   gp120/41 .   Fusion index .   Lignan glycoside.  

  • 참고문헌 (13)

    1. Barroso-Gonzalez, J., Jaber-Vazdekis, N. E., Garcia-Exposito, L., Machado, J.-D., Zarate, R., Ravelo, A. G., Estevez-Braun, A., and Valenzuela-Fernandez, A., The lupane-type triterpene 30-oxo-calenduladiol is a CCR5 antagonist with anti- HIV-1 and anti-chemotactic activities. J. Biol. Chem., In press (2009). 
    2. Clancy, J., Tait-Kamradt, A., Petitaps, J., Manousos, M., McGuirk, P. R., and Subashi, T., Assay to detect and characterize human immunodeficiency virus type1 (HIV- 1) receptor antagonists, compounds that inhibit binding of the HIV-1 surface glycoprotein, gp120 to the CD4 receptor on human T lymphocyte. Antimicrob. Agents Chemother., 38, 2008-2013 (1994). 
    3. De Clercq, E., Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int. J. Antimicrob. Agents, 33, 307-320 (2009). 
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    5. He, Y., Cheng, J., Lu, H., Li, J., Hu, J., Qi, Z., Liu, Z., Jiang, S., and Dai, Q., Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains. Proc. Natl. Acad. Sci. U.S.A., 105, 16332-16337 (2008). 
    6. Huo, C., Liang, H., Zhao, Y., Wang, B., and Zhang Q., Neolignan glycosides from Symplocos caudata. Phytochemistry, 69, 788-795 (2008). 
    7. Kim, H. J., Lee, J. S., Woo, E.-R., Kim, M. K., Yang, B. S., Yu, Y. G., Park, H., and Lee, Y. S., Isolation of virus-cell fusion inhibitory components from Eugenia caryophyllata. Planta Med., 67, 277-279 (2001). 
    8. Kim, M. R., Moon, H. I., Chung, J. H., Moon, Y. H., Hahm, K. S., and Woo. E.-R., Matrix metalloproteinase-1 inhibitor from the stem bark of Styrax japonica S. et Z. Chem. Pharm. Bull., 52, 1466-1469 (2004). 
    9. Kim, M. R., Moon, H. T., Lee, D. G., and Woo, E.-R., A new lignan glycosides from the stem bark of Styrax japonica S. et Z. Arch. Pharm. Res., 30, 425-430 (2007).     
    10. Nakashima, H., Balzarini, J., Pauwels, R., Baba, M., Schols, D., and Desmyter, J., Anti-HIV-1 activity for antiviral compounds, as quantitated by a focal immunoassay in $CD4^{+}$ HeLa cells and a plaque assay in MT-4 cells. J. Virol. Methods, 29, 197-208 (1990). 
    11. Tochikura, T. S., Nakashima, H., Tanabe, A., and Yamamoto, N., Human immunodeficiency virus (HIV)-induced cell fusion: Quantification and its application for the simple and rapid screening of anti-HIV substances in vitro. Virology, 164, 542-546 (1988). 
    12. Woo, E.-R., Yoon, S. H., Kwak, J. H., Kim, H. J., and Park, H., Inhibition of gp120-CD4 interaction by various plant extracts. Phytomedicine, 4, 53-58 (1997). 
    13. Sodroski, J., Goh, W. C., Rosen, C., Campbell, K., and Haseitine, W. A., Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity. Nature, 322, 470-474 (1986). 
  • 이 논문을 인용한 문헌 (1)

    1. Park, Mu Seob ; Lee, Hyun Jong ; Lee, Yun Kyu ; Kim, Mu Ryeo ; Park, Hae Jin ; Kim, Jae Soo 2016. "Analgesic Effect of Styrax Japonica Pharmacopuncture on Formalin-Induced Pain in Rats" The acupuncture = 대한침구의학회지, 33(2): 97~108     

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