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Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.33 no.6, 2010년, pp.867 - 873   SCIE 피인용횟수: 1
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Peroxyl Radical Scavenging Capacity of Extracts and Isolated Components from Selected Medicinal Plants

Kim, Sun-Ju    (College of Pharmacy, Seoul National University   ); Kwon, Do-Young    (College of Pharmacy, Seoul National University   ); Kim, Yeong-Shik    (College of Pharmacy, Seoul National University   ); Kim, Young-Chul    (College of Pharmacy, Seoul National University  );
  • 초록

    We determined the ability of extracts and active components isolated from nine medicinal plants, Poncirus trifoliata, Astragalus membranaceus, Magnolia obovata, Salvia miltiorrhiza, Angelica dahurica, Cornus officinalis, Cnidium officinale, Pueraria lobata and Ostericum koreanum, to neutralize peroxyl radicals using the total oxyradical scavenging capacity (TOSC) assay. Peroxyl radicals were generated from thermal homolysis of 2,2'-azobis(2-methylpropionamidine) dihydrochloride, which oxidize ${\alpha}$ -keto- ${\alpha}$ -methiolbutyric acid to yield ethylene, and the TOSC of the substances tested is quantified from their ability to inhibit ethylene formation. Extracts from S. miltiorrhiza, M. obovata and P. lobata were determined to be potent peroxyl radical scavenging agents with a specific TOSC (sTOSC) being at least threefold greater than that of glutathione. Major constituents of the three plants, tanshinone, cryptotanshinone, 15,16-dihydrotanshinone, syringin, honokiol, magnolol, daidzein, puerarin and genistein, were examined for the antioxidant potential toward peroxyl radical. Puerarin and genistein were shown to have ${\mu}M$ sTOSCs at least ten-fold greater than sTOSC of glutathione. Daidzein, syringin and honokiol demonstrated the peroxyl radical scavenging capacity comparable to that of glutathione. The implication of peroxyl radical in lipid peroxidation and other cellular damage suggests a possible protective role for the extracts and isolated components in oxidative stress caused by this reactive oxygen species.

  • 주제어

    Reactive oxygen species .   Peroxyl Radical .   Antioxidant .   Total oxyradical scavenging capacity.  

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  • 이 논문을 인용한 문헌 (1)

    1. 2013. "" Journal of medicinal food, 16(10): 899~911     

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