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Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.33 no.6, 2010년, pp.881 - 887   SCIE
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Ferilnic Nirate Produces Delayed Preconditioning Against Myocardial Ischemia and Reperfusion Injury in Rats

Xu, Jing-Feng    (Department of Pharmacology, General Hospital of Beijing Military Command   ); Wang, Zhan-Qing    (Department of Pharmacology, General Hospital of Beijing Military Command   ); Wang, Jin-Ping    (Department of Pharmacology, General Hospital of Beijing Military Command  );
  • 초록

    To determine whether ferilnic nirate (FLNT) can precondition the rat heart against myocardial ischemia/reperfusion (I/R) damage and its mechanism, two groups of experiments were conducted. In the first group of experiments, rats were divided among four treatment groups: sham group; solvent with I/R (I/R control group); FLNT pretreatment with I/R (I/R FLNT group); and late ischemic preconditioning group (LPC group). In the second group of experiments without I/R, rats were divided into two treatment groups: control group and FLNT group. The results indicated that myocardial infarct size and the levels of creatine kinase and lactate dehydrogenase in the sera of the I/R FLNT group were significantly lower and the level of nitric oxide molecule and Mn-containing superoxide dismutase were significantly elevated in the heart tissue compared with I/R control group. The protein expression ratio of Bcl-2/Bax in heart tissue was significantly elevated in the I/R FLNT group. These results demonstrate FLNT is able to precondition rat hearts against myocardial ischemia/reperfusion damage to a similar level as that achieved via the late phase of ischemic preconditioning. The mechanism may involve the up-regulation of nitric oxide and the strengthening of anti-oxidant and anti-apoptosis cellular functions.


  • 주제어

    Nitric oxide .   Ischemic preconditioning .   Anti-oxidant .   Anti-apoptosis.  

  • 참고문헌 (21)

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