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Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.33 no.6, 2010년, pp.889 - 899   SCIE 피인용횟수: 1
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Mucoadhesive and Floating Chitosan-coated Alginate Beads for the Controlled Gastric Release of Amoxicillin

Sahasathian, Teerawat    (Program of Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn University   ); Praphairaksit, Nalena    (Department of Biology, Faculty of Science, Srinakarinwirot University   ); Muangsin, Nongnuj    (Department of Chemistry, Faculty of Science, Chulalongkorn University  );
  • 초록

    This work focused on the development of mucoadhesive and floating chitosan-coated alginate beads as a gastroretensive delivery vehicle for amoxicillin, towards the effective eradication of Helicobacter pylori, a major causative agent of peptic ulcers. Alginate was used as the core bead core polymer and chitosan as the mucoadhesive polymer coating. Amoxicillin-loaded alginate beads coated with 0.5% (w/v) chitosan (ALG/0.5%CHI) exhibited excellent floating ability, high encapsulation efficiency, high drug loading capacity, and a strong in vitro mucoadhesion to the gastric mucosal layer. In vitro, amoxicillin was released faster in simulated gastric fluid (pH 1.2, HCl) than in simulated intestinal fluid (phosphate buffer, pH 7.4). ALG/0.5%CHI could be prepared with a > 90% drug encapsulation efficiency and exhibited more than 90% muco-adhesiveness, 100% floating ability, and achieved sustained release of amoxicillin for over six hours in SGF.

  • 주제어

    Amoxicillin .   Chitosan-coated alginate beads .   Helicobacter pylori .   Mucoadhesive beads.  

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  • 이 논문을 인용한 문헌 (1)

    1. Lee, Jin-Sil ; Lee, Shin-Young ; Hur, Won 2011. "Preparation of Alginate-fibroin Beads with Diverse Structures" KSBB Journal, 26(5): 422~426     

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