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Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.33 no.6, 2010년, pp.947 - 957   SCIE 피인용횟수: 3
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Arctigenin, a Phenylpropanoid Dibenzylbutyrolactone Lignan, Inhibits Type I-IV Allergic Inflammation and Pro-inflammatory Enzymes

Lee, Ji-Yun    (Division of Pathophysiology and Pharmacology, College of Pharmacy, Chung-Ang University   ); Kim, Chang-Jong    (Division of Pathophysiology and Pharmacology, College of Pharmacy, Chung-Ang University  );
  • 초록

    We previously reported that arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan isolated from Forsythia koreana, exhibits anti-inflammatory, antioxidant, and analgesic effects in animal models. In addition, arctigenin inhibited eosinophil peroxidase and activated myeloperoxidase in inflamed tissues. In this study, we tested the effects of arctigenin on type I-IV allergic inflammation and pro-inflammatory enzymes in vitro and in vivo. Arctigenin significantly inhibited the heterologous passive cutaneous anaphylaxis induced by ovalbumin in mice at 15 mg/kg, p.o., and compound 48/80-induced histamine release from rat peritoneal mast cells at $10\;{\mu}M$ . Arctigenin (15 mg/kg, p.o.) significantly inhibited reversed cutaneous anaphylaxis. Further, arctigenin (15 mg/kg, p.o.) significantly inhibited the Arthus reaction to sheep's red blood cells, decreasing the hemolysis titer, the hemagglutination titer, and the plaque-forming cell number for SRBCs. In addition, arctigenin significantly inhibited delayed type hypersensitivity at 15 mg/kg, p.o. and the formation of rosette-forming cells at 45 mg/kg, p.o. Contact dermatitis induced by picrylchloride and dinitrofluorobenzene was significantly (p $A_2$ 2, and phosphodiesterase. Our results show that arctigenin significantly inhibited B- and T-cell mediated allergic inflammation as well as pro-inflammatory enzymes.


  • 주제어

    Arctigenin .   PCA .   RCA .   AR .   DTH .   Pro-inflammatory enzymes.  

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  • 이 논문을 인용한 문헌 (3)

    1. 2010. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 33(12): 1943~1951     
    2. 2011. "" Biomolecules & therapeutics, 19(4): 425~430     
    3. Lee, Jin Hwa ; Han, Jae Kyung ; Kim, Yun Hee 2014. "The Suppressive Effect of Th2 Cytokines Expression and the Signal Transduction Mechanism in MC/9 Mast Cells by Forsythiae Fructus Extracts" 大韓韓方小兒科學會誌 = The journal of pediatrics of Korean medicine, 28(3): 31~46     

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