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Journal of pharmacopuncture v.13 no.2, 2010년, pp.51 - 65   피인용횟수: 7

음곡(陰谷)에 시술한 동과인 약침이 LPS로 유도된 흰쥐의 신장염에 미치는 영향
Anti-inflammatory Effect of Benincasae Semen Herbal-acupuncture at KI10 on nephritis in rats

이정환    (대전대학교 한의과대학 침구학교실   ); 김정호    (대전대학교 한의과대학 침구학교실   ); 김영일    (대전대학교 한의과대학 침구학교실  );
  • 초록

    Objective : This study aimed to evaluate the effects of Benincasae Semen Herbal-acupuncture (BS-HA) at KI10 (Umgok) on nephritis induced by LPS in rat. Methods : Rats with nephritis induced by LPS, were treated with Benincasae Semen Herbal-acupuncture(BS-HA) injection at KI10. Two control groups, N.P. group and saline group, were treated with 26 gauge needle at KI10, 3 times a week. In Saline group normal saline was injected at KI10. To evaluate the effects of Benincasae. Semen Herbal-acupuncture at KI10 on nephritis in rats, WBC, Neutrophils in blood, BUN, Creatinine TNF- $\alpha$ , CINC-1 in serum, urinal volume and creatinine and Total protein in urine, reanl TNF- $\alpha$ , renal MPO were measured and reanl tissue was also analyzed. Results: BS-HA injected at KI10 significantly inhibited WBC and neutrophil in blood. creatinine in serum, and MPO in kidney of LPS-stimulated rats. BS-HA injected at KI10 reduced concentration of neutrophil in renal tissue of LPS-stimulated rats. Conclusion : BS-HA at KI10 has a therapeutic effect for nephritis in LPS-stimulated rat There fore, it is suggested that BS-HA at KI10 may be an useful therapeutics in clinical field after further researches.


  • 주제어

    Nephritis .   Herbal-acupuncture .   KI10 .   Benincasae Semen .   LPS.  

  • 이미지/표/수식 (14)

    • Blood cell counts in LPS-stimulated rats.
    • Blood chemistry analysis in LPS-stimulated rats.
    • Unine analysis in LPS-stimulated rats.
    • Inflammatory activity in kidney of LPS-stimulated rats.

    논문관련 이미지

  • 참고문헌 (29)

    1. 杜鎬京. 동의신계학. 서울: 성보사. 2003:141-459. 
    2. Axtelle T, Pribble J. IC14, a CD14 specific monoclonal antibody is a potential treatment for patients with severe sepsis. J Endotoxin Res. 2001;7(4):310-4. 
    3. Lee ES, Ju HK, Moon TC, Lee E, Jahng Y, Lee SH, Son JK, Baek SH, Chang HW. Inhibition of nitric oxide and tumor necrosis factor-alpha (TNF-alpha) production by propenone compound through blockade of nuclear factor (NF)-kappa B activation in cultured murine macrophages. Biol Pharm Bull. 2004;27(5):617-20. 
    4. Mukaida N, Ishikawa Y, Ikeda N, Fujioka N, Watanabe S, Kuno K, Matsushima K. Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-kappaB and regulation of cytokine production/action through beta2 integrin in vivo. J Leukoc Biol. 1996;59(2):145-51. 
    5. Lazarov S, Balutsov M, Ianev E. The role of bacterial endotoxins, receptors and cytokines in the pathogenesis of septic (endotoxin) shock. Vutr Boles. 2000;32(4):33-40. 
    6. Scott MG, Hancock RE. Cationic antimicrobial peptides and their multifunctional role in the immune system. Crit Rev Immunol. 2000;20(5):407-31. 
    7. 康秉秀, 高雲彩, 金圭烈, 金先熙, 盧昇鉉, 朴涌基외. 본초학. 서울: 영림사. 2000:477. 
    8. 대한침구학회 교재편찬위원회. 침구학(상). 파주: 집문당. 2008:175-6. 
    9. Korean association of Internal medicine. Harrison's Principles of Internal Medicine. 16th ed. Seoul: MIP. 2006:1827-48. 
    10. Kim KM, Lee H, Kang HJ, Lee YH, Yim YK. Anti-inflammatory Effect of Dianthi Semen Herbal-acupuncture at KI10 on nephritis in rats. Korean J Meridian & Acupoint. 2009;26(1):61-77.     
    11. Park BM, Hur B, Yim YK. Anti-inflammatory Effect of Plantaginis Semen Herbal-acupuncture at KI10 on LPS-induced nephritis in rats. Korean J Meridian & Acupoint. 2009;26(2):127-43.     
    12. Kim SK, Song HJ, Park KH, Shin MK. Studies on the Expectorant Activities of Water Extract of Semen Benincasae and its Fractions in the Rat Trachea. Korean J Herbology. 2003;18(1):115-26. 
    13. Qadrie ZL, Hawisa NT, Khan MW, Samuel M, Anandan R. Antinociceptive and anti-pyretic activity of Benincasa hispida (thunb.) cogn. in Wistar albino rats. Pak J Pharm Sci. 2009;22(3):287-90. 
    14. Lee KH, Choi HR, Kim CH. Anti-angiogenic effect of the seed extract of Benincasa hispida Cogniaux. J Ethnopharmacol. 2005;97(3):509-13. 
    15. Arthur C. Guyton, John E. Hall. Textbook of Medical Physiology. 10th ed. Seoul: Jungdam. 2002:318-20, 452-4. 
    16. 張仲景. 欽定四庫全書 子部五醫家類-券2 金?要略. 서울: 대성문화사. 1995:734-1113. 
    17. 南京中醫學院. 諸病源候論校釋. 北京: 人民衛生出版社. 1983:464. 
    18. Ivan M. Roitt, Peter J. Delves. Roitt`s Essential immunology. 10th ed. U.S.A: Blackwell science. 2001:250-1. 
    19. 대한약침학회 학술위원회. 약침학. 서울: 엘스비어코리아. 2008:3-8. 
    20. Masayo Naito, Karol Bomsztyk, and Richard A. Zager. Endotoxin Mediates Recruitment of RNA Polymerase II to Target Genes in Acute Renal Failure. J Am Soc Nephrol. 2008;19(7):1321-30. 
    21. Suzanne Heemskerk, Arianne van Koppen, Luc van den Broek, Geert J. M. Poelen, Alfons C. Wouterse, Henry B. P. M. Dijkman, Frans G. M. Russel, and Rosalinde Masereeuw. Nitric oxide differentially regulates renal ATPbinding cassette transporters during endotoxemia. Pflugers Arch. 2007;454(2):321-34. 
    22. Won-Il Choi, Kun Young Kwon, Jeong Wook Seo, John Beagle, Deborah A Quinn, and Charles A Hales. The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury. BMC Infect Dis. 2009;9:80. 
    23. T R WELCH, M FRENZKE, D WITTE, and A E DAVIS III. C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis. Clin Exp Immunol. 2002;130(1):43-8. 
    24. E. Noiri, S. Kuwata, K. Nosaka, K. Tokunaga, T. Juji, Y. Shibata, and K. Kurokawa. Tumor necrosis factor-alpha mRNA expression in lipopolysaccharide-stimulated rat kidney. Chronological analysis of localization. Am J Pathol. 1994;144(6):1159-66. 
    25. Watanabe K, Koizumi F, Kurashige Y, Tsurufuji S, Nakagawa H. Rat CINC, a member of the interleukin-8 family, is a neutrophilspecific chemoattractant in vivo. Exp Mol Pathol. 1991;55(1):30-7. 
    26. Nakagawa H, Komorita N, Shibata F, Ikesue A, Konishi K, Fujioka M, Kato H. Identification of cytokine-induced neutrophil chemoattractants (CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by granulation tissue in culture: purification, complete amino acid sequences and characterization. Biochem J. 1994;301(2):545-50. 
    27. Iida M, Watanabe K, Tsurufuji M, Takaishi K, Iizuka Y, Tsurufuji S. Level of neutrophil chemotactic factor CINC/gro, a member of the interleukin-8 family, associated with lipopolysaccharide-induced inflammation in rats. Infect Immun. 1992;60(4):1268-72. 
    28. Yi KN, Kwon OH. Clinical pathology file. 3rd ed. Seoul: Eui-Hak Publishing.2003:95-6, 102-3. 
    29. Hong Xiao, Peter Heeringa, Peiqi Hu, Zhi Liu, Minglang Zhao, Yasuaki Aratani, Nobuyo Maeda, Ronald J. Falk, and J. Charles Jennette. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulone phritis and vasculitis in mice. J Clin Invest. 2002;110(7):955-963. 
  • 이 논문을 인용한 문헌 (7)

    1. Ihm, Jee Soon ; Cho, Tae Hwan ; Yim, Yun Kyoung 2012. "The Effect of Junci Medulla Herbal-acupuncture at $KI_{10}$ on LPS induced Nephritis in Rats" 大韓鍼灸醫學會誌 = The Journal of Korean Acupuncture & Moxibustion Medicine Society, 29(6): 73~83     
    2. Yim, Yun-Kyoung 2012. "Anti-Inflammatory Effect of Polygoni Avicularis Herba Herbal-Acupuncture at KI10 on LPS-Induced Nephritis in Rats" Korean journal of acupuncture, 29(4): 598~603     
    3. Cho, Eun ; Kang, Jae-Hui ; Lee, Hyun 2012. "Anti-inflammatory Effect of Akebiae Lignum Parmacopuncture at $KI_{10}$ on LPS-induced Acute Nephritis in Rats" 大韓鍼灸醫學會誌 = The Journal of Korean Acupuncture & Moxibustion Medicine Society, 29(3): 41~53     
    4. Kwak, Kyu In ; Kang, Jae Hui ; Lee, Hyun 2013. "The Effect of Phaseoli Semen Herbal-acupuncture at $KI_{10}$ in Lipopolysaccharide Induced Acute Nephritis in Rats" The acupuncture = 대한침구의학회지, 30(3): 61~73     
    5. Han, Je Geun ; Kim, Yang Seob ; Kim, Byung Soo ; Yim, Yun Kyoung 2014. "The Effect of Alismatis Rhizoma Herbal-acupuncture at $KI_{10}$ on LPS-induced Nephritis in Rats" The acupuncture = 대한침구의학회지, 31(1): 51~60     
    6. Kim, Yun Joo ; Kang, Jae Hui ; Lee, Hyun 2014. "The Effect of Tokoro Rhizoma Pharmacopuncture at $KI_{10}$ in Lipopolysaccharide Induced Acute Nephritis in Rats" The acupuncture = 대한침구의학회지, 31(2): 39~50     
    7. Lee, Jeong-Yun ; Jang, Seung-Hoon ; Jeon, Jong-Ik ; Yim, Yun-Kyoung 2015. "Effects of Polyporus Herbal-acupuncture at KI10 on LPS-induced nephritis in rats" Journal of Korean Medicine = 대한한의학회지, 36(3): 73~83     

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