본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of pharmacopuncture v.13 no.2, 2010년, pp.67 - 73   피인용횟수: 9

뇌졸중 후 우울증에 대한 황련해독탕 약침의 안전성 및 유효성 평가를 위한 임상 시험
The Clinical pilot study of Hwangryunhaedok-tang Pharmacopunctue therapy on Post-stroke depression

제준태    (원광대학교 한의과대학 심계내과학 교실   ); 이상관    (원광대학교 한의과대학 심계내과학 교실  );
  • 초록

    Objective : The purpose of this study is to determine the efficacy and safely of Hwangryunhaedok-tang Pharmacopuncture (HHT-PA) therapy on post-stroke depression (PSD) in stroke patients. Methods : Fifteen PSD patients has been recruited and evaluated with liver function test (LFT) and renal function lest (RFT) and depression scales, Beck Depress ion Inventory (BDI) and Hamilton Depression Rating Scale (HAM-D) before and after HHT-PA treatment. Results : HAM-D score significantly decreased after HHT-PA treatment regard less of improving of motor function. But BDI score did not decrease significantly. All results of LFT and RFT were in normal range before and after HHT-PA treatment Conclusion : These results showed that HHT-PA decrease PSD symptoms and has safety on stroke patients, although has no effect on improving of motor impairment.


  • 주제어

    Hwangryunhaedok-tang Pharmacopuncture .   Post-stroke depression .   HAM-D .   BDI.  

  • 이미지/표/수식 (4)

    • Normal Range of LFT, RFT in Laboratory of Wonkwang University Medical Center, Gwangju.
    • General Characteristic of Stroke Patients

    논문관련 이미지

  • 참고문헌 (31)

    1. 전국한의과대학심계내과학교실. 심계내과학. 서울: 군자출판사. 2006:265-393. 
    2. 안용팔, 이숙자, 양승한, 배광웅. 뇌졸중 편마비 환자의 의식구조. J.of Korean acad.of Rehab.Med.. 1984;8(2):92-8. 
    3. Demecour CL, Caplan D. The relationship of depression to symptomatology and lesion site in aphasic patients. Cortex. 1991;27:385-401. 
    4. Kauhanen ML, Korpelainen JT, Hitunen P. Aphasia, depression, and non-verbal cognitive impairment in ischaemic stroke. Cerebrovasc Dis. 2000;10:455-61. 
    5. Kim P, Warren S, Madill H. Quality of life of stroke survivors. Qual Life Res. 1999;8:293-301. 
    6. King RB. Quality of life after stroke. Stroke. 1996;28:1467-72. 
    7. Schwartz JA, Speed NM, Brunberg JA. Depression in stroke rehabilitation. Biol Psychiatry. 1993;33:694-9. 
    8. Herrmann N, Black SE, Lawrence J. The Sunnybrook Stroke Study: a prospective study of depressive symptoms and functional outcome. Stroke. 1998;29:618-24. 
    9. Ramasubbu R, Robinson RG, Flint AJ. Functional impairment associated with acute poststroke depression: the Stroke Data Band Study. J Neuropsychiatry Clin Neurosci. 1998;10:26-33. 
    10. Kotila M, Numminen H, Waltimo O. Poststroke depression and functional recovery in a population-based stroke register. The Finnstroke study. Eur J Neruol. 1999;6:309-12. 
    11. Pohjasvaara T, Vataja R, Leppavuori A. Depression in an independent predictor of poor long-term functional outcome post-stroke. Eur J Neurol. 2001;8:315-9. 
    12. Kauhanen M, Korpelainen JT, Hiltunen P. Poststoke depression correlates with cognitive impairment and neurological deficits. Stroke. 1999;30:1875-80. 
    13. Sinyor D, Amato P, Kaloupek DG. Post-stroke depression:relationships to functional impairment, coping strategies, and rehabilitaion outcome. Stroke. 1986;17:1102-7. 
    14. Paolucci S, Antonucci G, Pratesi L. Poststroke depression and its role in rehabilitation of inpatients. Arch Phys Med Rehabil. 1999;80:985-90. 
    15. Pohjasvaara T, Vataja R, Leppavuori A. Depression in an independent predictor of poor long-term functional outcome post-stroke. Eur J Neurol. 2001;8:315-9. 
    16. Gillen R, Tennen H, Mckee TE. Depressive symptoms and history of depression predict rehabilitation effeciency in stroke patients. Arch Phys Med Rehabil. 2001;82:1645-9. 
    17. Neau JP, Ingrand P, Mouille-Brachet C. Functional recovery and social outcome after cerebral infarction in young adults. Cerebrosc Dis. 1998;8:296-302. 
    18. Chemerinski E, Robinson RG, Kosier JT. Improved recovery in activities of daily living associated with remission of poststroke depression. Stroke, 2001;32:113-7. 
    19. Kondo Y, Kondo F, Asanuma M, Tanaka K, Ogawa N. Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse. Neurochem Res. 2000;25(2):205-9. 
    20. Kabuto H, Asanuma M, Nishibayashi S, Iida M, Ogawa N. Chronic administration of Orengendoku-to(TJ15) inhibitis ischemia-induced changes in brain indoleamine metabolism and muscarnic receptor binding in the Mongolian gerbil. Neurochem Res. 1997;22(1):33-6. 
    21. Kim YO, Leem K, Park J, Lee P, Ahn DK, Lee BC, Park HK, Suk K, Kim SY, Kim H. Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia. J. Ethnopharmacology. 2001;77(2-3):183-8. 
    22. 신길조, 조기호, 금영석, 배형섭, 이경섭. 황련해독탕의 약침제제의 안정성 및 효능에 관한 연구. 경희한의대논문집. 1994;17(1):85-115. 
    23. 설현, 육태한. 견정혈 황련해독탕약침이 심박변이율(HRV)에 미치는 영향. 대한침구학회지. 2004;21(6):37-50. 
    24. Cho GL, Kim JU, Lee YJ, Rhim EK, Shin SH, Kim DW, Hong SH, Joo JC. Two cases of Chest Heating Sensation treated by Hwangryunhaedok-tang Herbal-Acapuncture. 2003;6(2):127-135.     
    25. Jang HH, Lee DY, Lee SH, Kang HW, Lyn YS, Clinical Studies on HWANGRYUNHAEDOKTANG Herbal Acapuncture Therapy on Headache. 2003;6(1):52-60.     
    26. 王懷德. 太平聖惠方 1. 서울:한성사. 1980:3211-3. 
    27. Han HM, Yum TH, Shin YW, Kim KH, Yoon DJ, Chung KJ. A standardization study of back depression inventory in Korea. Neuropsychiatry 1986;25:487-98. 
    28. Hedlund JL, Viewig BW. The Hamilton rating scale for depression. Journal of Operational Psychiatry. 1979;10(2):149-165. 
    29. 이중서, 배승오, 안용민, 박두병, 노경선, 신현균, 우행원, 이홍식, 한상익, 김용식. 한국판 Hamilton 우울증 평가 척도의 신뢰도, 타당도 연구. J.Korean Neuropsychiatr Assoc. 2005;44(4):456-65. 
    30. Robinson RG. Poststroke Depression : Prevalence, Diagnosis, Treatment, and Disease Progression. Biol psychiatry 2003;54:376-87. 
    31. Huff W, Steckel R, Sistzer M. Poststroke depression : Risk factors and effects on the course of the stroke. Nervenarzt 2003;74:104-14. 
  • 이 논문을 인용한 문헌 (9)

    1. Choi, Ji-Hye ; Kim, Lae-Hee ; Yun, Jong-Min ; Moon, Byung-Soon 2011. "Study of Clinical Research Acupuncture Treatment on Post-stroke Depression" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 25(6): 1119~1128     
    2. Lee, Je-Won ; Lee, Bo-Mae-Na ; Jang, Woo-Seok ; Hwang, Ha-Yeon ; Baek, Kyung-Min 2012. "Poststroke Depression : A Review of the Latest Oriental Medicine Articles" 대한한방내과학회지 = The journal of internal Korean medicine, 33(4): 448~464     
    3. Choi, San-Ho ; Rhim, Hyung-Moon ; Oh, Jae-Gun ; Rhim, Jin-Yung ; Kang, Hyung-Won ; Kim, Yun-Sik ; Han, Chang-Ho ; Lee, In ; Moon, Sang-Kwan ; Yun, Hen-Ja ; Sung, Kang-Kyung ; Lee, Sang-Kwan 2012. "Standard Pattern Identifications for Post Stroke Depression by Delphi Method" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 26(3): 367~375     
    4. Lee, Eun Hee ; Choi, Woo Chang ; Jung, In Chul 2013. "Preliminary Study to Develop the Instrument on Pattern Identifications for Depression" 동의신경정신과학회지 = Journal of oriental neuropsychiatry, 24(4): 435~450     
    5. Lee, Il-Suk ; Park, Kee-Eon ; Hong, Hae-Jin ; Song, In-Ja ; Sung, Kang-Keyng ; Lee, Sang-Kwan 2014. "Correlation between Post-Stroke Depression and Cold, Heat, Deficiency and Excess Patterns" 대한한방내과학회지 = The journal of internal Korean medicine, 35(1): 50~58     
    6. Lee, Il-Suk ; Kim, Mun-Soo ; Lee, Sang-Kwan 2014. "Study of Efficacy and Safety of Tianwangbuxin-dan for Poststroke Depression: A Randomized, Double Blinded, Non-inferiority Trial" 대한한방내과학회지 = The journal of internal Korean medicine, 35(2): 145~156     
    7. Lee, Hun-Soo ; Kang, Wee-Chang ; Jung, In-Chul 2015. "Reliability and Validity Analysis of the Instrument on Pattern Identifications for Depression" 동의신경정신과학회지 = Journal of oriental neuropsychiatry, 26(4): 407~416     
    8. Lee, Jin-Ho ; Ha, In-Hyuk ; Kim, Me-Riong ; Chung, Hwa-Jin ; Lee, Jae-Woong ; Kim, Min-Jeong ; Kim, Eun-Jee ; Lee, In-Hee 2016. "Study on Long-Term Preservation of Hwangnyunhaedok-Tang Pharmacopuncture" Journal of Korean Medicine Rehabilitation : JKMR = 한방재활의학과학회지, 26(2): 51~59     
    9. Kim, Hwan ; Lee, Hun-Soo ; Lee, Eun Jung ; Park, Joon-Ho ; Kang, Wee-Chang ; Jung, In Chul 2016. "Correlation between Instrument on Pattern Identification for Depression and Psychological Tests by Statistical Analysis" 동의신경정신과학회지 = Journal of oriental neuropsychiatry, 27(3): 131~146     

 저자의 다른 논문

  • 제준태 (6)

    1. 2009 "膈下逐瘀湯이 Diethylnitrosamine과 CCl4로 유발된 흰쥐의 肝癌 形成과 肝損傷에 미치는 영향" 大韓藥鍼學會誌 = Journal of Korean pharmacopuncture institute 12 (4): 63~76    
    2. 2009 "3개 지역에 따른 허혈성 뇌혈관 질환의 요일 별 발생 특징 비교" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine 23 (5): 1167~1171    
    3. 2009 "무산소성 뇌증환자의 이소성 골화증에 대한 빈소산 치험례" 大韓韓醫學方劑學會誌 = Herbal formula science 17 (2): 225~231    
    4. 2011 "전기침이 결박 스트레스 반응에 미치는 영향 : 억제성 회피 과제, 강제 수영 시험, 스트레스 호르몬 반응 연구" 대한한방내과학회지 = The journal of internal Korean medicine 32 (1): 100~112    
    5. 2011 "수면제한이 청소년의 타액 호르몬에 미치는 영향" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine 25 (2): 311~317    
    6. 2012 "복부 및 사지 부위의 전기침 자극이 전두근에서 측정한 SEMG 변화에 미치는 영향 - 자율신경계의 변화에 대한 임상적 접근을 위한 사전 연구 -" 대한한방내과학회지 = The journal of internal Korean medicine 33 (1): 14~25    
  • 이상관 (42)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
유료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 이용한 콘텐츠
이 논문과 함께 출판된 논문 + 더보기