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Journal of ginseng research = 高麗人參學會誌 v.34 no.2, 2010년, pp.132 - 137   피인용횟수: 1
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Korean Red Ginseng Protects Oxidative Injury Caused by Lead Poisoning

Park, Myoung-Soo    (Department of Physiology, Research Institute for Medical Sciences, Chungnam National University School of Medicine   ); Cho, Eun-Jung    (Department of Physiology, Research Institute for Medical Sciences, Chungnam National University School of Medicine   ); Lee, Sang-Ki    (Department of Physiology, Research Institute for Medical Sciences, Chungnam National University School of Medicine   ); Lee, Eun-Ji    (Department of Physiology, Research Institute for Medical Sciences, Chungnam National University School of Medicine   ); Lee, Dae-Sik    (Department of Physical Therapy, Joongbu University   ); Lee, Kwon-Ho    (Department of Physical Therapy, Joongbu University   ); Jeon, Byeong-Hwa    (Department of Physiology, Research Institute for Medical Sciences, Chungnam National University School of Medicine  );
  • 초록

    Lead (Pb) is a metal that is generally considered to be toxic to the cardiovascular system. Pb-exposed animals display the evidence of increased oxidative stress and hypertension. The current study was designed to examine whether Korean red ginseng (KRG) has protective effects against Pb-induced hypertension and oxidative stress in Pb-exposed rats. Male Sprague-Dawley rats were randomly assigned to Pb exposure or control groups. KRG was administered in drinking water at a concentration of 100 mg/kg/day; the control group received plain drinking water. Animals in the Pb-exposed groups were provided with drinking water containing 100 ppm Pb acetate for 12 weeks. Blood pressure, plasma glutathione, blood Pb concentration, and hematologic data, such as red blood cell quantity, were determined. Pb poisoning was assessed by measuring the blood Pb concentration. Pb exposure (100 ppm) for 12 weeks resulted in a marked rise in systolic blood pressure and blood Pb concentration, as well as a significant reduction in plasma glutathione levels and red blood cell quantity. Other measurements, such as heart rate, body weight, and white blood cell quantity, were unchanged. Treatment with KRG significantly lowered blood pressure, raised plasma glutathione and increased red blood cell numbers in Pb-exposed animals; it also had no effect on heart rate, body weight, or white blood cell quantity. However, the elevated blood Pb concentration was not reduced by treatment with KRG (100 mg/kg). Taken together, these data indicate that treatment with KRG in Pb-exposed animals can reduce oxidative stress and lower blood pressure, suggesting that KRG might be protective against Pb-exposed hypertension and oxidative stress.


  • 주제어

    Korean red ginseng .   Lead .   Blood pressure .   Glutathione .   Blood lead concentration.  

  • 참고문헌 (24)

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  • 이 논문을 인용한 문헌 (1)

    1. Lee, Keyong-Ho ; Rhee, Ki-Hyeong 2012. "Effect of Taraxacum Mongolicum Extract on Serum Heavy Metal Levels and Blood Parameters of Albino Rats Exposed to Lead and Mercury" 한국환경농학회지 = Korean journal of environmental agriculture, 31(3): 264~270     

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