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Oriental pharmacy and experimental medicine : OPEM v.10 no.2, 2010년, pp.51 - 58   피인용횟수: 1
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Effects of Vitex rotundifolia on radical scavenging and nitric oxide production

Choi, Jae-Ki    (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University   ); Cha, Dong-Seok    (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University   ); Lee, Yong-Jae    (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University   ); Ko, Sung-Hoon    (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University   ); Park, Ho-Jun    (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University   ); Lee, Se-Yeoun    (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University   ); Choi, Jae-Hyuk    (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University   ); Jeon, Hoon    (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University  );
  • 초록

    Vitex rotundifolia (V. rotundifolia) has been used for treating headache, dizziness, toothache and removal of fever as a traditional medicine in Korea. In the present study, we examined the antioxidant and anti-inflammatory activities of 85% methanol extract of V. rotundifolia. In various radical scavenging assays, V. rotundifolia exhibited strong scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl free radical, superoxide radical, nitric oxide. To elucidate the anti-inflammatory properties of V. rotundifolia, we investigated the inhibition effects of nitric oxide production in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. V. rotundifolia suppressed nitric oxide production, iNOS and COX-2 expression dose-dependently through suppression of NF- $\hat{e}B$ activation without notable cytotoxicity. These findings mean that V. rotundifolia may be beneficial in oxidative stress-mediated inflammatory disorders.


  • 주제어

    Vitex rotundifolia .   Antioxidant .   Anti-inflammatory.  

  • 참고문헌 (21)

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  • 이 논문을 인용한 문헌 (1)

    1. Kim, You-Ah ; Lee, Jung-Im ; Hong, Joo-Wan ; Jung, Myoung-Eun ; Seo, Young-Wan 2011. "Antioxidant Activity of Flavonoids Isolated from Vitex rotundifolia" Ocean and polar research, 33(3): 255~263     

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