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Oriental pharmacy and experimental medicine : OPEM v.10 no.2, 2010년, pp.66 - 78  
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Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Al-Ashban, R.M.    (Central Laboratory for Drug Analysis, Ministry of Health and Saudi Food and Drug Authority Joint Venture, King Saud Medical Complex   ); Abou-Shaaban, R.R.    (Central Laboratory for Drug Analysis, Ministry of Health and Saudi Food and Drug Authority Joint Venture, King Saud Medical Complex   ); Shah, A.H.    (Central Laboratory for Drug Analysis, Ministry of Health and Saudi Food and Drug Authority Joint Venture, King Saud Medical Complex  );
  • 초록

    Acute (24 h) and chronic (90 days) oral toxicity studies on the ethanol extract of Trigonella foenumgraecum Leguminosae (L.) seeds were carried out. Acute dosages were 0.5, 1.0 and 3 g/kg while chronic dosage was 100 mg/kg per day of the extract. All morphological, biochemical, haematological and spermatogenic changes, in addition to mortality, body weight changes and any change in vital organs were recorded. Histopathological investigations were done on vital organs. Growth arrest in the treated animals was observed. The treated mice gained no significant weight during chronic treatment while there was a significant gain in body weight of the control group mice. Biochemical studies revealed a significant decrease in blood sugar levels of fenugreek treatment groups while haematological parameters remained comparable to the control. In the treatment, male group there was a significant decrease in weight of testes as compared to the control. There was a marginal weight gain in kidney weight of mice after chronic treatment as compared to the control. Fenugreek chronic treatment caused a highly significant spermatotoxic effects in male mice.


  • 주제어

    Fenugreek .   Acute toxicity .   Chronic toxicity studies .   Slowness of growth .   Blood glucose lowering potential .   Spermatotoxic effect.  

  • 참고문헌 (81)

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