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Oriental pharmacy and experimental medicine : OPEM v.10 no.2, 2010년, pp.79 - 85  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Hepatoprotective and antioxidant activity of the methanolic extract of Mucuna pruriens Bak. roots

Mujeeb, M.    (Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy   ); Bagri, P.    (Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy   ); Aeri, V.    (Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy   ); Khan, S.A.    (Department of Pharmacy, Oman Medical College  );
  • 초록

    The methanolic extract of natural roots of Mucuna pruriens was screened for hepatoprotective and antioxidant effects in carbon tetrachloride ( $CCl_4$ ) induced hepatotoxicity in Albino rats. The degree of protection was measured by estimating biochemical parameters like serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, total protein and level of serum bilirubin (both total and direct). The extract also reduced $CCl_4$ induced lipid peroxidation both in-vitro and in-vivo. Hepatoprotective activity of methanolic extract at dose 300 mg/kg body weight, i.p., was comparable with standard drug Silymarin (25 mg/kg, i.p.). Furthermore, histopathological experiments were also carried out to support the study.


  • 주제어

    Mucuna pruriens .   Hepatoprotective activity .   Antioxidant activity .   Carbon tetrachloride.  

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