본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Oriental pharmacy and experimental medicine : OPEM v.10 no.2, 2010년, pp.103 - 110  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Seed extracts of a Bangladeshi medicinal plant Abrus precatorius L. show antifertility activity in female rats

Hannan, M.A.    (Department of Biochemistry, Faculty of Agriculture, Bangladesh Agricultural University   ); Hossain, M.A.    (Department of Biochemistry, Faculty of Agriculture, Bangladesh Agricultural University   ); Islam, M.T.    (Ecological Chemistry, School of Agriculture and Rural Development, Bangladesh Open University  );
  • 초록

    The seed powder of Abrus precatorius L. has traditionally been used as oral contraceptive agent by the women in some rural areas in Bangladesh. The present study aimed to examine the antifertility activity of A. precatorius seed extracts in experimental female rats. Finely ground seeds were extracted with aqueous acetone followed by successive partitioning with n-hexane, ethyl acetate (EtOAc), methanol (MeOH) and water. Water suspended crude seed powder, organic fractions of acetone extract and a standard contraceptive drug ( $Nordette^{(R)}28$ ) were separately administered orally to the female rats for 30 days. n-Hexane, EtOAc and MeOH solubles at the doses of 2, 4 and 6 mg/rat/day, respectively and crude seed powder at 100 mg/rat/day exhibited 100% antifertility activity with lowest levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and $17{\beta}$ -estradiol. Histological study of ovary and uterus of these rats exhibited reduced number of developing follicles and increased number of atretic follicles in the ovary, and fewer uterine glands with shrunken morphology, reduced endometrial height, poor vascularity and compact stroma in uterus. However, the activities of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase and the body weight of the rats remained almost unaffected in all the seed extract treated rats compared to control. These results suggest that A. precatorius seed extracts reduced the levels of serum FSH, LH and $17{\beta}$ -estradiol probably by affecting hypothalamic-pituitary-gonadal axis. The reduced levels of these hormones might have affected the oestrous cycle, follicular development, and subsequently the establishment of pregnancy in treated rats.


  • 주제어

    Abrus precatorius .   Antifertility effect .   Seed extracts .   Gonadotropins .   Female rat.  

  • 참고문헌 (19)

    1. de Wolff-Exalto EA. (1982) Influence of gonadotropins on early follicles cell development and early oocyte growth in immature rat. J. Reprod. Fertl. 66, 637-642. 
    2. Dwivedi SK, Sharma MC. (1985) Therapeutic evaluation of an indigenous drug formulation against scabies in pigs. Indian Journal of Veterinary Medicine. 5, 97-100. 
    3. Hughes FM, Gorospe WC. (1991) Biochemical identification of apoptosis in granulosa cells: evidence for a potential mechanism underlying molecular atresia. Endocrinology. 129, 2415-2422. 
    4. Kirtikar KR, Basu BD. (1980) Indian Medicinal Plants, vol. I. 2nd ed. pp. 763-767, Bishen Singh Mahendra Pal Singh, India. 
    5. Monago CC, Akhidue V. (2003) Antidiabetic effect of crude glycoside of A. precatorius in alloxan diabetic rabbits. Global Journal of Pure and Applied Sciences. 9, 35-38. 
    6. Monago CC, Alumanah EO. (2005) Antidiabetic effect of chloroform-methanol extract of A. precatorius Linn seed in alloxan diabetic rabbit. J. Appl. Sci. Environ. Mgt. 9, 85-88. 
    7. Nimrod A, Erickson GF, Ryan KJ. (1976) A specific receptor in granulosa cells: properties of binding in vitro. Endocrinology. 98, 56-64. 
    8. Nwodo OWC, Alumanah EO. (1991) Studies of A. precatorius seeds II: antidiarrhoeal activity. J. Ethnopharmacol. 31, 395-398. 
    9. Rajaram N, Janardhanan K. (1992) The chemical composition and nutritional potential of the tribal pulse, A. precatorius L. Plant Foods Hum. Nutr. 42, 285-290. 
    10. Ratnasooriya WD, Premakumara GA, Tillekeratne LM. (1991) Post-coital contraceptive activity of crude extracts of Sri Lankan marine red algae. Contraception. 50, 291-299. 
    11. Rao MV. (1987) Antifertility effects of alcoholic seed extract of A. precatorius Linn. in male albino rats. Acta Eur Fertil. 18, 217-220. 
    12. Sinha S, Mathur RS. (1990) Effect of steroidal fraction of seeds of A. precatorius Linn. on rat testis. Indian J. Exp. Biol. 28, 752-756. 
    13. Sinha R. (1990) Post-testicular antifertility effects of A. precatorius seed extract in albino rats. J. Ethnopharmacol. 28, 173-181. 
    14. Strauss III J, Coutiferis C. (1999) The endometrium and myometrium: resolution and dysfunction. In: Reproductive Endocrinology, Pathophysiology and Clinical Management, edited by Jen SSC, Jaffle RB, Barbieri RL, pp. 218-256, Saunders Co., USA. 
    15. Thakur SC, Thakur SS, Chaube SK and Singh SP. (2005) An etheral extract of kamala (Mallotus philippinensis Lam.) seed induces adverse effects on reproductive parameters of female rats. Reprod. Toxicol. 20, 149-156. 
    16. Tilly JL, Kowalski KI, Johnson AL, Hsueh AJW. (1991) Involvement of apoptosis in ovarian follicular atresia and post-ovulatory regression. Endocrinology. 129, 2799-2801. 
    17. Terranova PF. (1981) Steroidogenesis in experimentally induced atretic follicles of the hamster: estradiol to progesterone synthesis. Endocrinology. 108, 1885. 
    18. Wassarman PM, Albertini DF. (1994) The mamalian ovum. In: The Physiology of Reproduction, edited by Knobil E, Neill JD, vol. 1. 2nd ed. pp. 79-122. 
    19. Watt JM, Breyer-Brandwijk MG. (1962) The medicinal and poisonous plants of Southern and Eastern Africa, 2nd ed. p.1063, Livingstone, London. 

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
유료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기