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Oriental pharmacy and experimental medicine : OPEM v.10 no.2, 2010년, pp.116 - 122   피인용횟수: 1
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The improving effects of Saengmaeksan on ulcerative colitis

Kim, Min-Cheol    (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude   ); Kim, Su-Jin    (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude   ); Choi, In-Young    (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude   ); Ki, Ji-Ye    (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude   ); Kim, Dae-Seung    (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude   ); Jeon, Yong-Deok    (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude   ); Bae, Go-Eun    (Department of Oriental Pharmacy, C  ); Choi, Sun-Kyung   Jeong, Hyun-Ja   Park, Yun-Jum   Kim, Hyung-Min   Um, Jae-Young   Hong, Seung-Heon  
  • 초록

    Saengmaeksan (SMS) is a well known Korean traditional herbal prescription, which consists of 3 different herbs, Radix Ophiopogonis, Radix Ginseng, and Fructus Schisandrae. SMS has been commonly used in various disease including respiratory system and cardiovascular System in Korea. The objective of this study is to find out the improving effects of SMS against Dextran Sulfate Sodium (DSS)-induced ulcerative colitis. SMS reduced clinical signs of DSS-induced colitis, including body weight loss, shorten colon length, and increased disease activity index. The results showed that SMS significantly inhibited the activation of nuclear factor- ${\kappa}B$ p65 in the colon tissues of DSS-treated mice. In addition, we observed that result showed that the levels of IL-6 in plasma were increased in DSS treated group compared to those of the normal group, but these increased levels were reduced by administration with SMS. Taken together, these findings suggest that SMS has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation.


  • 주제어

    Saengmaeksan .   Dextran Sulfate Sodium .   Ulcerative colitis .   Nuclear factor- ${\kappa}B$ p65 .   Interleukin-6.  

  • 참고문헌 (22)

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  • 이 논문을 인용한 문헌 (1)

    1. Jung, Ho-Kyung ; Jung, Won-Seok ; Ahn, Byung-Kwan ; Kang, Byoung-Man ; Yeo, Jun-Hwan ; Cha, Seon-Woo ; Park, Chun-Geon ; Cho, Jung-Hee ; Cho, Hyun-Woo 2014. "Peucedanum japonicum Thunberg Leaf Alleviates the Symptoms of Dextran Sulfate Sodium Induced Ulcerative Colitis in Mice" 韓國資源植物學會誌 = Korean journal of plant resources, 27(5): 421~428     

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