본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of pharmaceutical investigation v.40 no.3, 2010년, pp.139 - 153  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Functional Implications of Transporters Under Nitrosative Stress Conditions

Yu, Kyung-Ha   (College of Pharmacy, Seoul National UniversityUU0000691  ); Maeng, Han-Joo   (College of Pharmacy, Seoul National UniversityUU0000691  ); Chung, Suk-Jae   (College of Pharmacy, Seoul National UniversityUU0000691  );
  • 초록

    Nitrosative stress is defined as pathophysiological conditions that are related to covalent modifications of proteins by nitration/nitrosylation by forms of nitrogen oxide ( $NO_x$ ), leading to DNA damage, ultimately, cell death. This type of stress condition appears to be associated with a number of disease states, including diabetes, inflammation and neurodegenerative diseases. Since these pathological conditions are frequently chronic in nature and, thus, require long-term treatment, changes in pharmacokinetics are likely to affect the therapy. Transporters are membrane proteins that facilitate the movement of substrates, including drugs, across plasma membranes of epithelial / endothelial cells. Since it is now increasingly evident that transporters are pharmacokinetically significant, functional alteration of transporters by this stress condition may have therapeutic relevance. In this review, experimental techniques that are used to study both in vivo and in vitro nitrosative stress are summarized and discussed, along with available literature information on the functional implication of transporters under conditions of nitrosative stress conditions. In the literature, both functional induction and impa irment were apparently present for both drug transporter families [i.e., ATP-binding cassette (ABC) and solute carrier families (SLC)]. Furthermore, a change in the function of a certain transporter appears to have temporal dependency by impairment in the early phase of nitrosative stress and induction thereafter, suggesting that the role of nitrosative stress is complex in terms of functional implications of the transporters. Although the underlying mechanisms for these alterations are not fully understood, protein nitration/nitrosylation appears to be involved in the functional impairment whereas transcript factor(s) activated by nitrosative stress may play a role, at least in part, in functional induction. Interestingly, functional induction under conditions of nitrosative stress has not been observed for SLC transporters while such impairment has been documented for both ABC and SLC transporters. Further investigations appear to be necessary to fully delineate the underlying reasons for these differences on the impact and importance of nitrosative stress conditions.


  • 주제어

    Nitrosative stress .   Nox .   Functional alteration of Transporters .   Nitrosative stress models .   Nox donors.  

  • 참고문헌 (93)

    1. Van Waarde, W.M., Verkade, H.J., Wolters, H., Havinga, R., Baller, J., Bloks, V., Muller, M., Sauer, P. J., Kuipers, F., 2002. Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. Gastroenterology. 122, 1842-1852. 
    2. Vodovotz, Y., Chesler, L., Chong, H., Kim, S.J., Simpson, J.T., 1999. W. DeGraff, G.W. Cox, A.B. Roberts, D.A. Wink and M.H. Barcellos-Hoff, Regulation of transforming growth factor beta1 by nitric oxide, Cancer Res., 59, 2142-2149. 
    3. Wang, J.H., Scollard, D.A., Teng, S., Reilly, R.M., Piquette-Miller, M., 2005. Detection of P-glycoprotein activity in endotoxemic rats by 99mTc-sestamibi imaging. J. Nucl. Med. 46, 1537-1545. 
    4. Wang, P.G., Xian, M., Tang, X., Wu, X., Wen, Z., Cai, T. Janczuk, A. J., 2002. Nitric oxide donors: chemical activities and biological applications. Chem Rev. 102, 1091-1134. 
    5. Yamamoto, T., Bing, R. J., 2000. Nitric oxide donors. Proc. Soc. Exp. Biol. Med. 225, 200-206. 
    6. Yamauchi, A., Dohgu, S., Nishioku, T., Shuto, H., Naito, M., Tsuruo, T., Sawada, Y., Kataoka, Y., 2007. An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function. Cell. Mol. Neurobiol. 27, 263-270. 
    7. Yaren, H., Mollaoglu, H., Kurt, B., Korkmaz, A., Oter, S., Topal T., Karayilanoglu, T., 2007. Lung toxicity of nitrogen mustard may be mediated by nitric oxide and peroxynitrite in rats. Res. Vet. Sci. 83, 116-122. 
    8. Zhang, C. Walker, L.M. Mayeux, P.R., 2000. Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney. Biochem. Pharmacol. 59, 203-209. 
    9. Zhou, G., Kuo, M.T., 1997. NF-kappaB-mediated induction of mdr1b expression by insulin in rat hepatoma cells. J. Biol. Chem. 272, 15174-15183. 
    10. Bauer, B., Hartz, A.M., Miller, D.S., 2007. Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol. Pharmacol. 71, 667-675. 
    11. Bernstein, H., Holubec, H., Bernstein, C., Ignatenko, N., Gerner, E., Dvorak, K., Besselsen, D., Ramsey, L., Dall'Agnol, M., Blohm-Mangone, K., Padilla-Torres, A.J., Cui, H., Garewal, H., Payne, C. M., 2006. Unique dietary-related mouse model of colitis. Inflamm. Bowel. Dis. 12, 278-293. 
    12. Bridges, C.C., Ola, M.S., Prasad, P.D., El-sherbeny, A., Ganapathy, V., Smith, S. B., 2001. Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells. Am. J. Physiol. Cell. Physiol. 281, C1825-C1836. 
    13. Buffoli, B., Pechanova, O., Kojsova, S., Andriantsitohaina, R., Giugno, L., Bianchi, R., Rezzani, R., 2005. Provinol prevents CsA-induced nephrotoxicity by reducing reactive oxygen species, iNOS, and $NF-_{kappa}B$ expression. J. Histochem. Cytochem. 53, 1459-1468. 
    14. Cai, L., Wang, J., Li, Y., Sun, X., Wang, L., Zhou, Z., Kang, Y.J., 2005. Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy. Diabetes 54, 1829-1837. 
    15. Castegna, A., Aksenov, M., Aksenova, M., Thongboonkerd, V., Klein, J.B., Pierce, W.M., Booze, R., Markesbery, W.R., Butterfield, D. A., 2002. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radic. Biol. Med. 33, 562-571. 
    16. Celedon, G., Gonzalez, G., Pino, J., Lissi, E.A., 2007. Peroxynitrite oxidizes erythrocyte membrane band 3 protein and diminishes its anion transport capacity. Free Radic. Res. 41, 316-323. 
    17. Chen, C.F., Leu, F.J., Chen, H.I., Wang, D., Chou, S.J., 2006. Lack of a protective effect of insulin on three reperfusion-liver injury models in rats and mice. Transplant. Proc. 38, 2221-2225. 
    18. Cherrington, N.J., Slitt, A.L., Li, N., Klaassen, C.D., 2004. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab. Dispo. 30, 838-844. 
    19. Chirino, Y.I., Hernandez-Pando, R., Pedraza-Chaverri, J., 2004. Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats. BMC Pharmacol. 30, 4-20. 
    20. Chung, J.Y., Cho, J.Y., Yu, K.S., Kim, J.R., Oh, D.S., Jung, H.R., Lim, K.S., Moon, K.H., Shin S.G., Jang, I.J., 2005. Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers. Clin. Pharmacol. Ther. 78, 342-350. 
    21. Chung, K.K., Dawson, T.M., Dawson, V.L., 2005. Nitric oxide, Snitrosylation and neurodegeneration. Cell. Mo.l Biol. 51, 247-254. 
    22. Chung, S.J., Fung, H.L., 1990. Identification of the subcellular site for nitroglycerin metabolism to nitric oxide in bovine coronary artery smooth muscle cells. J. Pharmacol. Exp. Ther. 253, 614-619. 
    23. Chung, S.J., Chong, S., Seth, P., Jung, C.Y., Fung, H.L., 1992. Conversion of nitroglycerin to nitric oxide in microsomes of the bovine coronary artery smooth muscle is not primarily mediated by glutathione-S-transferases. J. Pharmacol. Exp. Ther. 260, 652-659. 
    24. Dixit, S.G., Zingarelli, B., Buckley, D.J., Buckley, A.R., Pauletti, G.M., 2005. Nitric oxide mediates increased P-glycoprotein activity in interferon-g-stimulated human intestinal cells. Am. J. Gastrointest. Liver Physiol. 288, 533-540. 
    25. Dulak, J., Jozkowicz, A., Dembinska-Kiec, A., Guevara, I., Zdzienicka, A., Zmudzinska-Grochot, D., Florek, I., Wojtowicz, A., Szuba, A., Cooke, J. P., 2000. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 20, 659-666. 
    26. Dutton, A.S., Fukuto, J.M., Houk, K.N., 2004. Mechanisms of HNO and NO production from Angeli's salt: density functional and CBS-QB3 theory predictions. J. Am. Chem. Soc. 126, 3795-3800. 
    27. Egleton, R.D., Campos, C.C., Huber, J.D., Brown, R.C., Davis, T.P., 2003. Differential effects of diabetes on rat choroid plexus ion transporter expression. Diabetes. 52, 1496-1501. 
    28. Escobales, N. Crespo, M.J., 2005. Oxidative-nitrosative stress in hypertension. Curr. Vasc. Pharmacol. 3, 231-246. 
    29. Essani, N.A. McGuire, G.M., Manning, A.M., Jaeschke, H., 1995. Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia. Biochem. Biophys. Res. Commun. 211, 74-82. 
    30. Feelisch, M., Noack, E., 1987. Correlation between nitric oxide formation during degradation of organic nitrites and activation of guanylate cyclase. Eur. J. Pharmacol. 142, 465-469. 
    31. Gharavi, N., El-Kadi, A.O., 2007. Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide. J. Pharm. Sci. 96, 2795-2807 
    32. Goligorsky, M.S., Brodsky, S.V., Noiri, E., 2002. Nitric oxide in acute renal failure: NOS versus NOS. Kidney Int. 61, 855-861. 
    33. Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P. L., Wishnok, J. S., Tannenbaum, S. R., 1982. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal. Biochem. 126, 131-138. 
    34. Grover, B., Buckley, D., Buckley, A.R., Cacini, W., 2004. Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes. J. Pharmacol. Exp. Ther. 308, 949-956. 
    35. Han, H., Kim, S.G., Lee, M.G., Shim, C.K., Chung, S.J., 2002. Mechanism of the reduced elimination clearance of benzylpenicillin from cerebrospinal fluid in rats with intracisternal administration of lipopolysaccharide. Drug Metab. Dispos. 30, 1214-1220. 
    36. Hartmann, G., Vassileva, V., Piquette-Miller, M., 2005. Impact of endotoxin-induced changes in P-glycoprotein expression on disposition of doxorubicin in mice. Drug Metab. Dispos. 33, 820-828. 
    37. Hawkins, B.T., Ocheltree, S.M., Norwood, K.M., Egleton, R.D., 2007. Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats. Leurosci. Lett. 411, 1-5. 
    38. Heemskerk, S., van Koppen, A., van den Broek, L., Poelen, G.J., Wouterse, A.C., Dijkman, H.B., Russel, F.G., Masereeuw, R., 2007. Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. Pflugers Arch. 454, 321-334. 
    39. Huie, R.E. Padmaja, S., 1993. The reaction of no with superoxide. Free Radic. Res. Commun.18, 195-199. 
    40. Ischiropoulos, H., al-Mehdi, A.B., 1995. Peroxynitrite-mediated oxidative protein modifications. FEBS Lett. 364, 279-282. 
    41. Jaworowicz Jr, D.J., Korytko, P.J., Lakhman, S.S. Boje, K.M., 1998. Nitric oxide and prostaglandin E2 formation parallels blood-brain barrier disruption in an experimental rat model of bacterial meningitis. Brain Res. Bull. 46, 541-546. 
    42. Jiang, M., Wei, Q., Pabla, N., Dong, G., Wang, C.Y., Yang, T., Smith, S.B., Dong, Z., 2007. Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Biochem. Pharmacol. 73, 1499-1510. 
    43. Josephine, A., Amudha, G., Veena, C.K., Preetha, S.P., Varalakshmi, P., 2007. Oxidative and nitrosative stress mediated renal cellular damage induced by cyclosporine A: role of sulphated polysaccharides. Biol. Pharm. Bull. 30, 1254-1259. 
    44. Kalitsky-Szirtes, J., Shayeganpour, A., Brocks, D.R., Piquette-Miller, M., 2004. Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats. Drug Metab. Dispos. 32, 20-27. 
    45. Kimura, H., Miura, S., Shigematsu, T., Ohkubo, N., Tsuzuki, Y., Kurose, I., Higuchi, H., Akiba, Y., Hokari, R., Hirokawa, M., Serizawa H., Ishii, H., 1997. Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease. Dig. Dis. Sci. 42, 1047-1054. 
    46. Kobayashi, T., Matsumoto, T., Kamata, K., 2000. Mechanisms underlying the chronic pravastatin treatment-induced improvement in the impaired endothelium-dependent aortic relaxation seen in streptozotocin-induced diabetic rats. Br. J. Pharmacol. 131, 231-238. 
    47. Korenaga, D., Takesue, F., Kido, K., Yasuda, M., Inutsuka, S., Honda, M., Nagahama, S., 2002. Impaired antioxidant defense system of colonic tissue and cancer development in dextran sulfate sodium-induced colitis in mice. J. Surg. Res. 102, 144-149. 
    48. Korkmaz, A., Yaren, H., Topal T., Oter, S., 2006. Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation. Arch. Toxicol. 80, 662-670. 
    49. Kowaluk, E.A., Fung, H.L., 1991. Vascular nitric oxide-generating activities for organic nitrites and organic nitrates are distinct. J. Pharmacol. Exp. Ther. 259, 519-525. 
    50. Kuhad, A., Tirkey, N., Pilkhwal, S., Chopra, K., 2006. Renoprotective effect of Spirulina fusiformis on cisplatin-induced oxidative stress and renal dysfunction in rats. Ren Fail. 28, 247-254. 
    51. Kuo, M.T., Liu, Z., Wei, Y., Lin-Lee, Y.C., Tatebe, S., Mills, G.B., Unate, H., 2002. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. Oncogene 21, 1945-1954. 
    52. Kusuhara, H., Sugiyama, Y., 2004. Efflux transport systems for organic anions and cations at the blood-CSF barrier. Adv. Drug. Deliv. Rev. 56, 1741-1763. 
    53. Lass, P., Knudsen, G.M., 1990. Cerebral blood flow response to propranolol in streptozotocin diabetic rats. Neuroreport. 1, 232-234. 
    54. Ling, H., Li, X., Jha, S., Wang, W., Karetskaya, L., Pratt, B., Ledbetter, S., 2003. Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation. J. Am. Soc. Nephrol 14, 377-388. 
    55. Madrigal, J.L., Garcia-Bueno, B., Caso, J.R., Perez-Nievas, B.G., Leza, J.C. 2006. Stress-induced oxidative changes in brain. CNS Neurol. Disord. Drug Targets 5, 561-568. 
    56. Maeng, H.J., Kim, M.H., Jin, H.E., Shin, S.M., Tsuruo, T., Kim, S.G., Kim, D.D. Shim, C.K., Chung, S.J., 2007. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. Drug Metab. Dispos. 35, 1996-2005. 
    57. Marfella, R., Cacciapuoti, F., Grassia, A., Manfredi, E., De Maio, G., Caruso, G., Pepe, M., Nittolo, G., Cacciapuoti, F., 2006. Role of the ubiquitin-proteasome system in carotid plaque instability in diabetic patients. Acta. Cardiol. 61, 630-636. 
    58. Markesbery, W.R. Lovell, M.A., 1998. Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease. Neurobiol. Aging 19, 33-36. 
    59. Masuda, H., Tanaka, T., Takahama, U., 1994. Cisplatin generates superoxide anion by interaction with DNA in a cell-free system. Biochem. Biophys. Res. Commun. 203, 1175-1180. 
    60. Mecocci, P., MacGarvey, U. Beal, M.F., 1994. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36, 747-751. 
    61. Minamizono, A., Tomi, M., Hosoya, K. 2006. Inhibition of dehydroascorbic acid transport across the rat blood-retinal and -brain barriers in experimental diabetes. Biol. Pharm. Bull. 29, 2148-2150. 
    62. Moncada, S., Bolanos, J.P., 2006. Nitric oxide, cell bioenergetics and neurodegeneration. J. Neurochem. 97, 1676-1689. 
    63. Mooradian, A.D., 1987. Blood-brain barrier choline transport is reduced in diabetic rats. Diabetes. 36, 1094-1097. 
    64. Niemi, M., Schaeffeler, E., Lang, T., Fromm, M.F., Neuvonen, M. Kyrklund, C., Backman, J.T., Kerb, R. Schwab, M., Neuvonen, P.J., Eichelbaum, M., Kivisto, K.T., 2004. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). Pharmacogenetics. 14, 429-440. 
    65. Obrosova, I.G., Mabley, J.G., Zsengeller, Z., Charniauskaya, T. Abatan, O.I. Groves, J.T. Szabo, C., 2005. Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst. FASEB. J. 19, 401-403. 
    66. Olsson, L.E., Wheeler, M.A. Sessa, W.C., Weiss, R.M., 1998. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. J. Pharmacol. Exp. Ther. 284, 1203-1208. 
    67. Paik, J.Y., Lee, K.H., Ko, B.H, Choe, Y.S., Choi, Y., Kim, B.T., 2005. Nitric oxide stimulate 18F-FDG uptake in human endothelial cells through increased hexokinase activity and GLUT1 expression. J. Nucl. Med. 46, 365-370. 
    68. Palmer, R.M., Ashton, D.S., Moncada, S., 1988. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333, 664-666. 
    69. Park, S.U., Ferrer, J.V., Javitch, J.A., Kuhn, D.M., 2002. Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons. J. Neurosci. 22, 4399-4405. 
    70. Perez-Nievas, B.G., Garcia-Bueno, B., Caso, J.R., Menchen, L., Leza, J.C., 2007. Corticosterone as a marker of susceptibility to oxidative/nitrosative cerebral damage after stress exposure in rats. Psychoneuroendocrinology. 32, 703-711. 
    71. Rachmilewitz, D., Karmeli, F., Okon, E., Bursztyn, M., 1995. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity. Gut. 37, 247-255. 
    72. Radi, R., 2004. Nitric oxide, oxidants, and protein tyrosine nitration. Proc Natl Acad Sci USA. 101, 4003-4008. 
    73. Reynolds, P.D., Middleton, S.J., Hunter, J.O., Facer, P., Bishop, A., Evans, T. Polak, J.M., 1995. High expression of iNOS in colonic mucosa in ulcerative colitis. Gastroenterology 108, A903. 
    74. Ridnour, L.A., 2004. The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biol. Chem. 385, 1-10. 
    75. Romero, J.M., Bizzozero, O.A., 2006. Extracellular S-nitrosoglutathione, but not S-nitrosocysteine or $N_2O_3$, mediates protein S-nitrosation in rat spinal cord slices. J. Neurochem. 99, 1299-1310. 
    76. Sarandol, A., Sarandol, E., Eker, S.S., Erdinc, S., Vatansever, E., Kirli, S., 2007. Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems. Hum. Psychopharmacol 22, 67-73. 
    77. Schinkel, A.H., Wagenaar, E., van Deemter, L., Mol, C.A., Borst, P., 1995. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 96, 1698-1705. 
    78. Schwartz, I.F., Chernichovsky, T., Hagin, D., 2006. Differential regulation of L-arginine transporters (cationic amino acid transporter-1 and -2) by peroxynitrite in rat mesangial cells. Nephrol. Dial. Transplant. 21, 3409-3414. 
    79. Seril, D.N., Liao, J., Yang, G.Y., 2007. Colorectal carcinoma development in inducible nitric oxide synthase-deficient mice with dextran sulfate sodium-induced ulcerative colitis. Mol Carcinog. 46, 341-353. 
    80. Setsukinai, K., Urano, Y., Kakinuma, K., Majima, H.J., Nagano, T., 2003. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J. Biol. Chem. 278, 3170-3175. 
    81. Seven, I. Turkozkan, N. Cimen, B., 2005. The effects of nitric oxide synthesis on the Na+ ,K(+)-ATPase activity in guinea pig kidney exposed to lipopolysaccharides. Mol. Cell. Biochem. 271, 107-112. 
    82. Shao, B., Bergt, C., Fu, X., 2005. Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport. J. Biol. Chem. 280, 5983-5893. 
    83. Shen, S., Yu, S., Binek, J., Chalimoniuk, M., Zhang, X., Lo, S.C., Hannink, M., Wu, J., Fritsche, K., Donato, R., Sun, G.Y., 2005. Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells. Neurochem Int. 47, 298-307. 
    84. Shen, Y., Yu, H.M., Yuan, T.M. Gu, W.Z., Wu, Y.D., 2007. Intrauterine infection induced oligodendrocyte injury and inducible nitric oxide synthase expression in the developing rat brain. J. Perinat. Med. 35, 203-209. 
    85. Song, I.S., Lee, I.K., Chung, S.J., Kim, S.G., Lee, M.G., Shim, C.K., 2002. Effect of nitric oxide on the sinusoidal uptake of organic cations and anions by isolated hepatocytes. Arch. Pharm. Res. 25, 984-988.     
    86. Taguchi, K., Kobayashi, T., Hayashi, Y., Matsumoto, T. Kamata, K., 2007. Enalapril improves impairment of SERCA-derived relaxation and enhancement of tyrosine nitration in diabetic rat aorta. Eur. J. Pharmacol. 556, 121-128. 
    87. Taha, Z.H., 2003. Nitric oxide measurements in biological samples. Talanta. 61, 3-10. 
    88. Tahara, H., Shono, M., Kusuhara, H., Kinoshita, H., Fuse, E., Takedate, A., Otagiri, M., Sugiyama, Y., 2005. Molecular cloning and functional analysis of OAT1 and Oat3 from Synomolgus monkey kidney. Pharm. Res. 22, 647-660. 
    89. Takahashi, M., Ogasawara, K., Takeda, K., Hashimoto, W., Sakihara, H., Kumagai, K., Anzai, R. Satoh, M., Seki, S., 1996. LPS induces NK1.1+ alpha beta T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells. J. Immunol. 156, 2436-2442. 
    90. Thevenod, F., Friedmann, J.M., Katsen, A.D., Hauser, I.A., 2000. Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen speciesinduced apoptosis. J. Biol. Chem. 275, 1887-1896. 
    91. Turkozkan, N., Unlu, A., Ertabak, A., Cimen, B., Karabicak, U., 2001. The effects of peroxynitrite on erythrocytes. Clin. Chem. Lab. Med. 39, 1263-1266. 
    92. Uchiyama, T., Matsuda, Y., Wada, M., Takahashi, S., Fujita, T., 2005. Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett. 579, 2499-2506. 
    93. Unlu, A.N., Turkozkan, B., Cimen, Karabicak, U., Yaman, H., 2001. The effect of Escherichia coli-derived lipopolysaccharides on plasma levels of malondialdehyde and 3-nitrotyrosine. Clin. Chem. Lab. Med 39, 491-493. 

 저자의 다른 논문

  • Chung, Suk-Jae (36)

    1. 1986 "음이온 모델 화합물 아마란스의 담즙배설에 미치는 타우로데옥시콜레이트의 영향" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 16 (3): 110~117    
    2. 1986 "Effect of Bile Salt on the Pharmacokinetics of Bretylium in the Rat (I) - Increased Lipophiiicity of Bretylium by Ion-Pair Complexation with Taurodeoxycholate -" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 9 (2): 111~114    
    3. 1995 "Bioeuqivalence Study of Nabumetone Tablets in Man" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 18 (5): 340~345    
    4. 1997 "프로리포솜을 이용한 클렌부테롤의 경피흡수 제제화" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 27 (4): 303~311    
    5. 1997 "정상 및 손상된 흰쥐 피부에 국소 적용된 $^{125}I-rhEGF$의 체내 이행" 약학회지 = Yakhak hoeji 41 (6): 730~736    
    6. 1997 "헤어리스마우스 피부 국소에 적용된 $^{125}I-rhEGF$의 피부흡수 및 체내 분포" 약학회지 = Yakhak hoeji 41 (6): 737~748    
    7. 1998 "$3{\times}3$ 라틴 방격법 모델에 따른 생물학적 동등성 시험의 통계 해석 : 온단세트론 제제에 대한 적용 예" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 28 (1): 35~42    
    8. 1998 "록소닌 정(록소프로펜 나트륨 무수물 60 mg)에 대한 록시펜 정의 생물학적 동등성" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 28 (3): 185~191    
    9. 1998 "$K-BEtest^{\circledR}$, 새로운 생물학적 동등성 시험 통계처리 프로그램의 개발" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 28 (4): 223~229    
    10. 1999 "제조 방법에 따른 간 모세담관막 소포계의 수송 특성 비교" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 29 (1): 13~19    

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기