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Journal of pharmaceutical investigation v.40 no.3, 2010년, pp.161 - 166  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Development of Fast Dissolving Tablet Containing Herb Extract by Freeze-Drying Technique

Kim, Jae-Il    (BK21 Project Team, College of Pharmacy, Chosun University   ); Choi, Hoo-Kyun    (BK21 Project Team, College of Pharmacy, Chosun University  );
  • 초록

    A fast dissolving tablet was developed using the freeze-drying technique. Hyeonggaeyeongyotang was selected as a model oriental medicine. Formulation and processing parameters were studied to obtain freeze-dried tablet with high drug loading, good palatability, and fast disintegration time. $Kollidon^{(R)}$ CLM served as both matrix former and taste masking agent. Ethanol used as co-solvent, decreased the disintegration time of tablet. Aspartame was employed to impart better taste. Drying condition was found to have a major effect in the morphology of the tablets. Freeze-drying process was optimized to decrease the processing time and improve the appearance of the tablets.


  • 주제어

    Fast dissolving tablet .   Oriental medicine .   Crosspovidone .   Freeze-drying .   Hyeonggaeyeongyotang.  

  • 참고문헌 (19)

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    8. Kearney, P., Murray, O.J., Green, R., Gother, L.P., 2003. Fast dispersing dosage forms essentially free of mammalian gelatin. U.S. Patent 6509040. 
    9. Kearney, P., Wong, S.K., 1997. Method for making freeze-dried drug dosage form. U.S. Patent 5631023. 
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    13. Seager, H., 1998. Drug-delivery products and the zydis fast-dissolving dosage form. J. Pharm. Pharmacol. 50, 375-382. 
    14. Soter, N.A., 1989. Morphology of atopic eczema. Allergy 44, 16-19. 
    15. Sznitowska, M., 2005. The physical characteristics of lyophilized tablets containing model drug in different chemical forms and concentrations. Drug Research 62, 25-29. 
    16. Teagarden, D.L., Baker, D.S., 2002. Practical aspects of lyophilization using non-aqueous co-solvent systems. Eur. J. Pharm. Sci. 15, 115-133. 
    17. Technical information, 2008. Insoluble $Kollidon^{\circledR}$ grades. BASF. 
    18. Wittaya-areekul, S., 1999. Freeze-drying from non-aqueous solution. Mahidol Univ. J. Pharm. Sci. 26, 33-43. 
    19. Yarwood, R., 1990. “Zydis: A novel, fast dissolving dosage form. Manuf. Chem. 61, 36-37. 

 저자의 다른 논문

  • Kim, Jae-Il (1)

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