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Journal of pharmaceutical investigation v.40 no.3, 2010년, pp.187 - 192   피인용횟수: 1
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The Effects of Storage Conditions on the Stability of Porcine Placenta Extract-loaded Liposome Formulations

Noh, Sang-Myoung    (School of Pharmacy, Seoul National University   ); Park, Da-Eui    (School of Life Science and Biotechnology, Korea University   ); Im, Sae-Won    (School of Pharmacy, Seoul National University   ); Kim, Sun-Il    (School of Pharmacy, Seoul National University   ); Kim, Young-Bong    (Department of Animal Biotechnology, Konkuk University   ); Oh, Yu-Kyoung    (School of Pharmacy, Seoul National University  );
  • 초록

    We aimed to evaluate the effect of temperature, pH, and light conditions on the stability of porcine placental extract (PPE)-loaded liposomes with different surface charges. The size distribution profiles and in vitro release patterns were investigated by dynamic light scattering method and spectrophotometry. The stability of PPE-loaded liposomes was affected by the surface charges of the liposomes. As compared to neutral and anionic liposomes, cationic liposome formulations showed significantly lower physical stability. At the test storage conditions of different temperatures and pHs, the mean sizes of cationic PPE-loaded liposomes substantially increased. In contrast, neutral and anionic liposomes did not reveal significant changes in mean sizes upon various storage conditions. The neutral and anionic liposomes showed no significant differences in the release profiles of PPE after storage at various temperatures and pHs. Our results indicate that anionic and neutral liposome compositions might be more suitable for the formulations of PPE providing the higher stability.


  • 주제어

    Surface charges .   Stability of liposome .   Placenta extracts.  

  • 참고문헌 (11)

    1. Dragicevic-Curic, N., Grafe, S., Gitter, B., Winter, S., Fahr, A., 2010. Surface charged temoporfin-loaded flexible vesicles: in vitro skin penetration studies and stability. Int. J. Pharm. 384, 100-108. 
    2. Dragicevic-Curic, N., Winter, S., Stupar, M., Milic, J., Krajisnik, D., Gitter, B., Fahr A., 2009. Temoporfin-loaded liposomal gels: viscoelastic properties and in vitro skin penetration. Int. J. Pharm. 373, 77-84. 
    3. Dragicevic-Curic, N., Stupar, M., Miliae, J., Zoriae, T., Krajisnik, D., Vasiljeviae, D., 2005. Hydrophilic gels containing chlorophyllin-loaded liposomes: development and stability evaluation. Pharmazie 60, 588-592. 
    4. Eliyahu, H., Joseph, A., Schillemans, J.P., Azzam, T., Domb, A.J., Barenholz Y., 2007. Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically. Biomaterials 28, 2339-2349. 
    5. Kaasgaard, T., Andresen, T.L., 2010. Liposomal cancer therapy: exploiting tumor characteristics. Expert Opin. Drug Deliv. 7, 225-243. 
    6. Kim, D.C., Noh, S.M., Park, K.T., Kim, Y.B., Baek, K.H., Oh, Y.K., 2007. Transdermal delivery of porcine placenta extracts using linolenic acid-based emulsion formulations. J. Kor. Pharm. Sci. 37, 281-286.     
    7. Li, S., Goins, B., Phillips, W.T., Bao, A., 2010. Remote-loading labeling of liposomes with 99mTc-BMEDA and its stability evaluation: effects of lipid formulation and pH/chemical gradient. J. Liposome Res. ePub. 
    8. Marcato, P.D., Duran, N., 2008. New aspects of nanopharmaceutical delivery systems. J. Nanosci. Nanotechnol. 8, 2216-2229. 
    9. Ntimenou, V., Mourtas, S., Christodoulakis, E.V., Tsilimbaris, M., Antimisiaris, S.G., 2006. Stability of protein-encapsulating DRV liposomes after freeze-drying: A study with BSA and t-PA. J. Liposome Res. 16, 403-416. 
    10. Pietzyk, B., Henschke, K., 2000. Degradation of phosphatidylcholine in liposomes containing carboplatin in dependence on composition and storage conditions. Int. J. Pharm. 196, 215-218. 
    11. Sulkowski, W.W., Pentaka, D., Korus, W., Sulkowska, A., 2005. Effect of temperature on liposome structures studied using EPR spectroscopy. Spectroscopy 19, 37-42. 
  • 이 논문을 인용한 문헌 (1)

    1. 2011. "" Journal of pharmaceutical investigation, 41(1): 19~24     

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