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KSBB Journal v.25 no.1, 2010년, pp.97 - 102   피인용횟수: 1

티올키토산으로 피복된 EPA(Eicosapentaenoic acid) 함유 리포좀의 제조 및 아토피 감염 쥐에 대한 면역 특성
Preparation of Thiol-chitosan Coated EPA-containing Liposome and Immune Response in Mouse Model of Atopic Dermatitis

정효연    (전남대학교 공과대학 향장품학협동   ); 김진    (전남대학교 공과대학 신화학소재공학과   ); 이용욱    ((주)캠포트   ); 이기영    (전남대학교 공과대학 향장품학협동  );
  • 초록

    The enhancement of immunity for atopic dermatitis with application of eicosapentaenoic acid (EPA)-loaded liposome was evaluated on NC/Nga mice. The EPA-loaded liposome was coated with thiol-chitosan. The liposomes were characterized with transmission electron microscopy (TEM), surface zeta potential & particle size analyzer (Zeta-PSA) and differential scanning calorimetry (DSC). The loading efficiency of EPA in the liposome was about 4.7%. The particle size of the EPA-Ioaded liposome was about 230 nm. The values of Immunoglobulin E (IgE), interleukin-4 (IL-4), and tumor necrosis factor- $\alpha$ (TNF- $\alpha$ ) were reduced significantly with application of the EPA-loaded liposome. The interferon- $\gamma$ (IFN- $\gamma$ ) value was increased with the application effect. It is concluded that EPA loaded liposome have immunity advancing effects in mouse model of atopic dermatitis.


  • 주제어

    EPA .   Atopic dermatitis .   Immunity .   IgE .   IL-4 .   TNF- $\alpha$ .   IFN- $\gamma$.  

  • 참고문헌 (22)

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  • 이 논문을 인용한 문헌 (1)

    1. Lee, Mi-Jin ; Cho, Mun-Ku ; Oh, Suk-Heung ; Oh, Chan-Ho ; Choi, Dong-Seong ; Woo, Ja-Won ; Park, Ki-Hong ; Jung, Mun Yhung 2014. "Fatty Acid Composition, Contents of Tocopherols and Phytosterols, and Oxidative Stability of Mixed Edible Oil of Perilla Seed and Rice Bran Oil" 한국식품영양학회지 = The Korean journal of food and nutrition, 27(1): 59~65     

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