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Biomolecules & therapeutics v.18 no.3, 2010년, pp.308 - 315   SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Anti-Inflammatory Effect of Fermented Artemisia princeps Pamp in Mice

Joh, Eun-Ha    (Department of Life and Pharmaceutical Sciences, Kyung Hee University   ); Trinh, Hien-Trung    (Department of Life and Pharmaceutical Sciences, Kyung Hee University   ); Han, Myung-Joo    (Department of Food and Nutrition, Kyung Hee University   ); Kim, Dong-Hyun    (Department of Life and Pharmaceutical Sciences, Kyung Hee University  );
  • 초록

    Essential oil-excluded Artemisia princeps Pamp var Ssajuarissuk (AP) was fermented with Lactobacillus brevis K-1, which was isolated from cabbage Kimchi, and the anti-inflammatory effects of AP and fermented AP (FAP) on lipopolysaccharide (LPS)-induced inflammatory response in peritoneal macrophages were investigated. AP and FAP inhibited LPS-induced TNF- $\alpha$ , IL- $1{\beta}$ , COX-2, iNOS and COX-2 expression, as well as NF- ${\kappa}B$ activation. AP and FAP also reduced ear thickness, inflammatory cytokine (TNF- $\alpha$ , IL- $1{\beta}$ and IL-6) expression and NF- ${\kappa}B$ activation with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dermatitis in mice. Furthermore, AP and FAP also reduced exudate volume, cell number, protein amount, inflammatory cytokines (TNF- $\alpha$ , IL- $1{\beta}$ and IL-6) expression and NF- ${\kappa}B$ activation in carrageenan-induced air pouch inflammation in mice. The inhibitory effects of FAP were more potent than those of non-fermented AP. Based on these findings, we propose that FAP can improve inflammatory diseases, such as dermatitis, by inhibiting the NF- ${\kappa}B$ pathway.


  • 주제어

    Artemisia princeps Pamp var Ssajuarissuk .   Inflammation .   Dermatitis .   Fermentation.  

  • 참고문헌 (24)

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