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Biomolecules & therapeutics v.18 no.3, 2010년, pp.321 - 328   SCIE SCOPUS 피인용횟수: 4
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Anti-Inflammatory Activity of Constituents Isolated from Ulmus davidiana var. japonica

Zheng, Ming Shan    (College of Pharmacy, Yeungnam University   ); Yang, Ju-Hye    (College of Pharmacy, Yeungnam University   ); Li, Ying    (College of Pharmacy, Yeungnam University   ); Li, Xian    (College of Pharmacy, Yeungnam University   ); Chang, Hyeun-Wook    (College of Pharmacy, Yeungnam University   ); Son, Jong-Keun    (College of Pharmacy, Yeungnam University  );
  • 초록

    Twenty six compounds (1-26) were isolated from the root barks of Ulmus davidiana var. japonica. The anti-inflammatory activity of the isolated compounds were evaluated agai nst the generation of inflammatory chemical mediators in bone marrow-derived mast cells. Among them, compounds 10, 11, 13, 15 and 19 inhibited not only cyclooxygenase-2 dependent prostaglandin $D_2$ generation but also 5-lipoxygenase dependent leukotrien $C_4$ generation in a concentration-dependent manner. In addition, compounds 11, 12, 13, 15 and 19 also inhibited $\beta$ -hexosaminidase release, a marker of mast cell degranulation reaction, from bone marrow-derived mast cell. These results suggest that the anti-inflammatory activity of U. davidiana might in part occur by both the inhibition of eicosanoid generations and the degranulation reaction of mast cells.


  • 주제어

    Ulmus davidiana var.   japonica .   Bone marrow-derived mast cells .   Cyclooxygenase-2, 5-Lipoxygenase .   $\beta$-hexosaminidase .   Anti-inflammatory activity.  

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  • 이 논문을 인용한 문헌 (4)

    1. Song, Jeong-Ho ; Jang, Kyung-Hwan ; Lim, Hyo-In ; Park, Wan-Geun ; Bae, Kwan-Ho 2011. "Variation of Samara, Seed, Germination and Growth Characteristics of Ulmus davidiana var. japonica Nakai Populations" 韓國林學會誌 = Journal of Korean Forest Society, 100(2): 226~231     
    2. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1443~1450     
    3. 2014. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 37(6): 698~705     
    4. Lee, Inhwan ; Kwon, Da Hye ; Lee, Sun Hee ; Lee, Sung Do ; Kim, Deok Won ; Lee, Jong-Hwan ; Hyun, Sook Kyung ; Kang, Kyung-Hwa ; Kim, CheolMin ; Kim, Byoung Woo ; Hwang, Hye Jin ; Chung, Kyung Tae 2014. "Immune-modulation Effect of Ulmus macrocarpa Hance Water Extract on Balb/c Mice" 생명과학회지 = Journal of life science, 24(10): 1151~1156     

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