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해수산 클로렐라(Chlorella ellipsoidea) 유기용매 추출물의 항염증 효과
Anti-Inflammatory Effect of Chlorella ellipsoidea Extracted from Seawater by Organic Solvents

최유진    (동아대학교 의학과   ); 조월순    (동아대학교 의학과   ); 김현지    (동아대학교 의학과   ); 남병혁    (부신 테크노파크 해양생물산업육성센터   ); 강은영    (부신 테크노파크 해양생물산업육성센터   ); 오수정    (동아대학교 의학과   ); 이계안    (엔엘피(주)   ); 정민호    (동아대학교 의학과  );
  • 초록

    Chlorella has been reported to have certain beneficial physiological effects, including hypocholesterolemic, antihypertensive, antioxidative, and anti-tumor activities in animal and human studies. The aim of this study was to determine the anti-inflammatory activities of an 80% methanol extract(CE-Met), hexane fraction (CE-Hex), and ethyl acetate fraction (CE-EA) of Chlorella ellipsoidea in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage. Treatment with various concentrations of the C. ellipsoidea extract resulted m a significant, dose-dependent reduction in nitric oxide (NO) production by LPS-induced macrophages. The C. ellipsoidea extract significantly inhibited LPS-induced NO production accompanied by an attenuation of IL-6 and TNF- $\alpha$ formation in macrophages. These results suggest potent inhibit이y effects on the production of inflammatory mediators by a C. ellipsoidea extract. Thus, C. ellipsoidea extract may be a potent anti-inflammatory agent for troubled skin.

  • 주제어

    Chlorella ellipsoidea .   Anti-inflammation .   RAW264.   7 cells .   Nitricoxide .   Pro-inflammatory cytokines.  

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  • 이 논문을 인용한 문헌 (6)

    1. Sung, Mi-Sun ; Kim, Young-Hwa ; Choi, Young-Min ; Ham, Hyeon-Mi ; Jeong, Heon-Sang ; Lee, Jun-Soo 2011. "Anti-Inflammatory Effect of Erigeron annuus L. Flower Extract through Heme Oxygenase-1 Induction in RAW264.7 Macrophages" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(11): 1507~1511     
    2. Park, Sung-Chul ; Son, Dae-Yeul 2011. "Inhibitory Effects of Euphorbia supina Rafin on the Production of Pro-Inflammatory Mediator by LPS-Stimulated RAW 264.7 Macrophages" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(4): 486~492     
    3. Kim, Nam Young ; Lee, Young Duck ; Cho, Seok Cheol ; Shin, Yun Chul ; Lee, Hyeon Yong 2014. "Enhancement of Anti-inflammation Effect by Fermentation Process in Aronia melanocarpa (Michx.) Elliott Extract" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 22(6): 475~482     
    4. Cho, Hee-Sook ; Kim, Kyung-Hee 2015. "Quality Characteristics of Maejakgwas with Chlorella Powder" 韓國食生活文化學會誌 = Journal of the Korean Society of Food Culture, 30(5): 667~673     
    5. Cho, Hee-Sook ; Kim, Kyung-Hee 2016. "Effects of Chlorella Powder on Quality Characteristics of Yukwa" 韓國食生活文化學會誌 = Journal of the Korean Society of Food Culture, 31(2): 178~187     
    6. Kong, Cheong-Sik ; Lee, Jae-Dong ; Yoon, Moon-Joo ; Kang, Kyung-Hun ; Park, Si-Young ; Kang, Young-Mi ; Sung, Tae-Jong ; Kim, Jeong-Gyun 2016. "Quality Characteristics of Canned Boiled Oyster Crassostrea gigas and Canned Boiled Oyster Crassostrea gigas Added with Chlorella Processed in Various Sterilization Conditions" 한국수산과학회지 = Korean journal of fisheries and aquatic sciences, 49(4): 427~435     

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