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고지방 식이 흰쥐에서 오가피 추출물의 항산화 효과 및 지질 개선 효과
Antioxidant Effects and Improvement of Lipid Metabolism of Acanthopanacis cortex Water Extract in Rats Fed High Fat Diet

박영숙    (대구대학교 식품영양학과  );
  • 초록

    오가피 추출물이 고지방 식이를 급여한 흰쥐의 체내 지질대사, 심혈관계질환지수 항산화능 및 항산화 효소계에 어떤 영향을 미치는지 알아보고자 하였다. 연구 결과를 요약하면 아래와 같다. 1. 식이 섭취량은 고지방 식이군이 정상 식이군에 비해 유의적 (p


    The effects of an Acanthopanacis cortex water extract on lipid levels, lipid peroxide, total antioxidant status and antioxidant enzyme activities were evaluated in rats fed one of the following diets for six weeks: normal diet and deionized water (ND), normal diet and Acanthopanacis cortex water extract (NDC), high fat diet and deionized water (HFD), high fat diet and Acanthopanacis cortex water extract (HFDC). The food intakes were significantly lower, but the food efficiency ratios were significantly higher in the high fat diet groups. The level of HDL-cholesterol in the plasma was significantly increased and the levels of LDL-cholesterol and triglyceride in the plasma were significantly decreased by the Acanthopanacis cortex water extract in the high fat diet groups. As a a result, the AI (atherogenic index) and CRF (cardiac risk factor) were significantly lower in the high fat diet groups that were treated with Acanthopanacis cortex water extract. The triglyceride and the total cholesterol of the liver were also significantly upregulated in the high fat diet groups, while the total cholesterol of the liver decreased in response to treatment with Acanthopanacis cortex water extract (HFDC). The plasma and liver concentrations of thiobarbituric acid reactive substances (TBARS) were significantly reduced by the addition of Acanthopanacis cortex water extract to the normal diet groups. The total antioxidant status (TAS) in the plasma was significantly upregulated by adding Acanthopanacis cortex water extract to the high fat diet groups. The activities of SOD, catalase and GST were also significantly higher in the Acanthopanacis cortex water extract groups when compared to the ionized water groups. The activity of GSH-Px and the concentration of GSH in the liver were significantly higher following the addition of Acanthopanacis cortex water extract to the high fat diet groups. Taken together, these results suggest that a supplementation of the diet of rats fed a high fat diet with Acanthopanacis cortex water extract improves lipid metabolism, reduces lipid peroxide and improves the activities of antioxidant enzymes, which may have favorable effects on antioxidant systems by improving the total antioxidant status (TAS).


  • 주제어

    Acanthopanacis cortex .   lipid peroxidation .   antioxidant enzyme activities .   total antioxidant status.  

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    2. Kim, Kyung-Sook ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Jang, Jun-Bock ; Lee, Kyung-Sub 2011. "Effects of Acanthopanacis Cortex Radicis on the Apoptosis in HeLa cell and MCF-7 cell" 大韓韓方婦人科學會誌 = The Journal of Korean obstetrics & gynecology, 24(3): 14~27     
    3. Yu, Seok-Yeong ; Lee, Young-Jun ; Song, Ho-Seong ; Hong, Hee-Do ; Lim, Jeong-Ho ; Choi, Hyeon-Son ; Lee, Boo-Yong ; Kang, Suk-Nam ; Lee, Ok-Hwan 2012. "Antioxidant Effects and Nitrite Scavenging Ability of Extract from Acanthopanax cortex Shoot" 한국식품영양학회지 = The Korean journal of food and nutrition, 25(4): 793~799     
    4. Jin, So-Yeon ; Lee, Eun Ji ; Gil, Ga Young ; Joo, Shin Youn 2014. "Quality Characteristics and Antioxidant Activities of Cookies added Eleutherococcus sessiliflorus Leaf Powder" 東아시아食生活學會誌 = Journal of the East Asian Society of Dietary Life, 24(2): 234~241     
    5. Kim, Dae Hwan ; Choi, Mi-Ran ; Hong, Ji Eun ; Lee, Jae-Yong ; Lee, Soon Im ; Jung, Su Hwan ; Kim, Eun Ji 2014. "Effect of Mixture of Lactobacillus plantarum CECT 7527, 7528, and 7529 on Obesity and Lipid Metabolism in Rats Fed a High-fat Diet" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 43(10): 1484~1490     
    6. Lee, Hae-In ; Lee, Mi-Kyung 2015. "Effects of Scopoletin Supplementation on Insulin Resistance and Antioxidant Defense System in Chronic Alcohol-Fed Rats" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 44(2): 173~181     
    7. Lee, Jin Ho ; Kim, Min Jeong ; Lee, Jae Woong ; Kim, Me Riong ; Lee, In Hee ; Kim, Eun Jee 2015. "A Study on Standardization of Shinbaro Pharmacopuncture Using Herbal Medicines Identification Test and HPLC-DAD" The acupuncture = 대한침구의학회지, 32(2): 1~9     

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