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BMB reports v.43 no.6, 2010년, pp.389 - 399   SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Fertilization and the oocyte-to-embryo transition in C. elegans

Marcello, Matthew R.    (Waksman Institute and Department of Genetics Rutgers University   ); Singson, Andrew    (Waksman Institute and Department of Genetics Rutgers University  );
  • 초록

    Fertilization is a complex process comprised of numerous steps. During fertilization, two highly specialized and differentiated cells (sperm and egg) fuse and subsequently trigger the development of an embryo from a quiescent, arrested oocyte. Molecular interactions between the sperm and egg are necessary for regulating the developmental potential of an oocyte, and precise coordination and regulation of gene expression and protein function are critical for proper embryonic development. The nematode Caenorhabditis elegans has emerged as a valuable model system for identifying genes involved in fertilization and the oocyte-to-embryo transition as well as for understanding the molecular mechanisms that govern these processes. In this review, we will address current knowledge of the molecular underpinnings of gamete interactions during fertilization and the oocyte-to-embryo transition in C. elegans. We will also compare our knowledge of these processes in C. elegans to what is known about similar processes in mammalian, specifically mouse, model systems.


  • 주제어

    C.   elegans .   Egg activation .   Fertilization .   Oocyte-to-embryo transition .   Sperm-egg fusion.  

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