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BMB reports v.43 no.6, 2010년, pp.445 - 449   SCIE
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Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics

Park, Byung-Lae    (Department of Genetic Epidemiology, SNP Genetics, Inc.   ); Park, Se-Min    (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital   ); Park, Jong-Sook    (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital   ); Uh, Soo-Taek    (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital   ); Choi, Jae-Sung    (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital   ); Kim, Yong-Hoon    (Division of Internal Medicine, Chungbuk National University, College of Medicine   ); Kim, Mi-Kyeong    (Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Sciences   ); Choi, In-Seon S.    (Division of Pulmonology and Allergy, Department of Internal Medicine, Chung-Ang University Yongsan Hospital   ); Choi, Byoung-Whui    (Department of Internal Medicine and Institute of Allergy and Clinical Immunology, Seoul National University College of Medicine   ); Cho, Sang-Heon    (Division of Allergy and Immunology, Institute of Allergy, Department of Internal Medicine, Yonsei University College of M  ); Hong, Chein-Soo   Lee, Yong-Won   Lee, Jae-Young   Park, Choon-Sik   Shin, Hyoung-Doo  
  • 초록

    Aspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs. In this study, we investigated the relationship between Prostaglandin E2 receptor (PTGER) gene family polymorphisms and AIA in 243 AIA patients and 919 aspirin-tolerant asthma (ATA) controls of Korean ethnicity in two separate study cohorts. After genotyping 120 SNPs of the PTGER gene family for the $1^{st}$ cohort study, four SNPs in PTGER1, ten in PTGER3, six in PTGER3, and a haplotype of PTGER2 showed association signals with decreased or increased risk of AIA. Among the positively associated SNPs, one in PTGER1 and four in PTGER3 were analyzed in the $2^{nd}$ cohort study. The results show that rs7543182 and rs959 in PTGER3 retained their effect, although no statistical significance was retained in the $2^{nd}$ cohort study. Our findings provide further evidence that polymorphisms in PTGER3 might play a significant role in aspirin hypersensitivity among Korean asthmatics.


  • 주제어

    Aspirin intolerant asthma .   Asthma .   Prostaglandin E receptor(s) .   Single nucleotide polymorphism.  

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