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Natural product sciences v.16 no.2, 2010년, pp.99 - 106  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Protection by Methanol Extract of Longan (Dimocarpus Longan Lour.) Peel against Kainic acid-Induced Seizure

Jo, Young-Jun    (College of Pharmacy, Chungbuk National University   ); Eun, Jae-Soon    (College of Pharmacy, Woosuk University   ); Kim, Hyoung-Chun    (College of Pharmacy, Kangwon National University   ); Cho, Hwang-Eui    (College of Pharmacy, Chungbuk National University   ); Lee, Mi-Kyeong    (College of Pharmacy, Chungbuk National University   ); Hwang, Bang-Yeon    (College of Pharmacy, Chungbuk National University   ); Hong, Jin-Tae    (College of Pharmacy, Chungbuk National University   ); Moon, Dong-Cheul    (College of Pharmacy, Chungbuk National University   ); Oh, Ki-Wan    (College of Pharmacy, Chungbuk National University  );
  • 초록

    This experiment was undertaken to investigate whether methanol extract of fruit peel of Dimocarpus longan Lour. (MEFL) protects against kainic acid (KA)-induced seizure. Oral administration of MEFL (1, 2 and 4 mg/kg) increased KA (50 mg/kg)-induced survival rate and latency of convulsion onset, and deceased seizure scores and weight loss induced by intraperitoneal (i.p) injection of KA in mice. In addition, MEFL protected against cell death in the hippocampus of rat brain after KA-administration as analyzed by using TUNEL assay in rats. MEFL also significantly blocked seizure-form of electroencephalogram (EEG) power spectra induced by KA in rats. MEFL also inhibited elevation of [ $Ca^{2+}$ ]i and increased [ $Cl^-$ ]i induced by KA in cultured neuronal cells. Therefore, it is suggested that MEFL protects against seizure induced by KA, decreasing [ $Ca^{2+}$ ]i.


  • 주제어

    Dimocarpus longan .   Kainic acid (KA) .   Seizure .   Hippocampus .   Cell death .   [ $Ca^{2+}$]i.  

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