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Natural product sciences v.16 no.2, 2010년, pp.111 - 115   피인용횟수: 1
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Anti-inflammatory and Radical Scavenging Effects of Spirodela polyrrhiza

Jeon, Hoon    (College of Pharmacy, Woosuk University  );
  • 초록

    Anti-inflammatory and anti-oxidant effect of Spirodela polyrrhiza (Lemnaceae), a widely used traditional medicinal plant were investigated. In macrophages nitric oxide (NO) is released as an inflammatory mediator and has been proposed to be an important modulator of many pathophysiological conditions including inflammation. 85% MeOH extracts of S. polyrrhiza (0.01, 0.1, 1 mg/mL) suppressed nitric oxide production in interferone- $\gamma$ (IFN- $\gamma$ ) and lipopoloysaccharide(LPS)-stimulated macrophages. It also attenuated the expression of inflammatory enzymes like inducible NOS (iNOS) and cyclooxygenase-2(COX-2) as assessed by immunoblotting with specific antibodies. Moreover, the values obtained with DPPH radical, superoxide anion and NO radical scavenging assay showed that S. polyrrhiza has potent antioxidant properties as a natural ROS scavenger. The results of the present study suggest the potential use of S. polyrrhiza in the treatment of ROS-mediated chronic inflammatory diseases such as atherosclerosis and rheumatoid arthritis.

  • 주제어

    Spirodela polyrrhiza .   Nitric Oxide .   iNOS .   COX-2 .   Antioxidant.  

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  • 이 논문을 인용한 문헌 (1)

    1. 2011. "" Natural product sciences, 17(4): 303~308     

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