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Agonistic Anti-CD137 Monoclonal Antibody Treatment Induces CD11b+Gr-1+ Myeloid-derived Suppressor Cells

Lee, Jung-Mi    (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University   ); Seo, Jeong-Hwan    (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University   ); Kim, Yeon-Jeong    (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University   ); Kim, Yun-Sun    (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University   ); Ko, Hyun-Jeong    (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University   ); Kang, Chang-Yuil    (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University  );
  • 초록

    CD137 (4-1BB/tnfrsf9) has been shown to co-stimulate T cells. However, agonistic anti-CD137 monoclonal antibody (mAb) treatment can suppress $CD4^+$ T cells, ameliorating autoimmune diseases, whereas it induces activation of $CD8^+$ T cells, resulting in diverse therapeutic activity in cancer, viral infection. To investigate the CD137-mediated T cell suppression mechanism, we examined whether anti-CD137 mAb treatment could affect $CD11b^+Gr-1^+$ myeloid-derived suppressor cells (MDSCs). Intriguingly, anti-CD137 mAb injection significantly increased $CD11b^+Gr-1^+$ cells, peaking at days 5 to 10 and continuing for at least 25 days. Furthermore, this cell population could suppress both $CD8^+$ T cells and $CD4^+$ T cells. Thus, this study demonstrated that, for the first time, anti-CD137 mAb treatment could induce $CD11b^+Gr-1^+$ MDSCs under normal conditions, suggesting a possible relationship between myeloid cell induction and CD137-mediated immune suppression.


  • 주제어

    CD137 .   $CD11b^+Gr-1^+$ cells .   Myeloid-derived suppressor cells .   Immunosuppression.  

  • 참고문헌 (18)

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