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Food science and biotechnology v.19 no.3, 2010년, pp.655 - 661   SCIE 피인용횟수: 1
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Effect of Aqueous Antler Extract on Scopolamine-induced Memory Impairment in Mice and Antioxidant Activities

Lee, Mi-Ra    (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University   ); Yun, Beom-Sik    (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University   ); Zhang, Dong-Liang    (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University   ); Liu, Lei    (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University   ); Wang, Zhen    (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University   ); Wang, Chun-Ling    (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University   ); Gu, Li-Juan    (Daeduck Bio Research Institute   ); Wang, Chun-Yan    (Daeduck Bio Research Institute   ); Mo, Eun-Kyung    (Daeduck Bio Research Institute   ); Ly, Sung-Young    (Department of Food and Nutrition, College of Human Ecology, Chungnam National University   ); Sung, Chang-Keun    (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University  );
  • 초록

    This study was performed to estimate ameliorating effect of aqueous antler extract (AAE) on memory impairments induced by scopolamine (SCOP, 2 mg/kg, i.p.). Tacrine (THA, 10 mg/kg, p.o.) was used as a positive control. The passive avoidance test and Y-maze test results showed that a single AAE (200 mg/kg, p.o.) administration significantly restored memory impairment. Moreover, AAE or THA treatment significantly reduced the escape latency prolonged by SCOP during trial sessions in the Morris water maze test. In vivo study, AAE significantly inhibited acetylcholinesterase (AChE) activity (p


  • 주제어

    deer antler .   scopolamine .   acetylcholinesterase .   choline acetyltransferase .   antioxidant.  

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    1. 2015. "" Journal of the Korean Society for Applied Biological Chemistry, 58(1): 61~66   

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