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Food science and biotechnology v.19 no.3, 2010년, pp.717 - 724   SCIE 피인용횟수: 1
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Cytotoxic Effects of 7-O-Butyl Naringenin on Human Breast Cancer MCF-7 Cells

Park, Jong-Hwa    (Bio/Molecular Informatics Center, Konkuk University   ); Lee, Jin-Woo    (Department of Advanced Technology Fusion, Konkuk University   ); Paik, Hyun-Dong    (Bio/Molecular Informatics Center, Konkuk University, Division of Animal Life Science, Konkuk University   ); Cho, Ssang-Goo    (Bio/Molecular Informatics Center, Konkuk University, Division of Animal Life Science, Konkuk University   ); Nah, Seung-Yeol    (Bio/Molecular Informatics Center, Konkuk University, Department of Physiology, Collage of Veterinary Medicine, Konkuk University   ); Park, Yong-Sun    (Bio/Molecular Informatics Center, Konkuk University, Department of Advanced Technology Fusion, Konkuk University   ); Han, Ye-Sun    (Bio/Molecular Informatics Center, Konkuk University, Department of Advanced Technology Fusion, Konkuk University  );
  • 초록

    The effect of 7-O-butyl naringenin (BN), a chemically synthesized derivative of naringenin, was tested on the proliferation of human breast cancer MCF-7 cells. BN inhibited the proliferation of MCF-7 cells in dosedependent manner ( $IC_{50}$ : $67.5{\pm}2.1\;{\mu}M$ ), resulting in an increase in the sub-G1 phase cell population. BN induced the generation of intracellular reactive oxygen species (ROS), which were reduced by pretreatment with N-acetylcysteine (NAC). BN also increased the phosphorylation of stress-activated protein kinase/c-Jun $NH_4$ -terminal kinase 1/2 (SAPK/JNK1/2), c-Jun, and p38. However, the phosphorylation of extracellular-regulated kinase 1/2 (Erk1/2) was decreased in BN-treated cells. Pretreatment of cells with the specific inhibitors SP600125 and SB203580 diminished the BN-induced activation of SAPK/JNK1/2 and p38, respectively. These results indicate that the BN-induced cytotoxicity of MCF-7 cells is mediated by the generation of ROS as well as through the p38, SAPK/JNK1/2, and c-Jun activation signaling pathways. BN may therefore possess chemotherapeutic potential as an anti-proliferative agent.


  • 주제어

    7-O-butyl naringenin .   reactive oxygen species (ROS) .   stress-activated protein kinase/c-Jun $NH_4$-terminal kinase 1/2 (SAPK/JNK1/2) .   p38 .   c-Jun.  

  • 참고문헌 (26)

    1. Middleton E, Kandaswami C, Theoharides TC. The effect of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 52: 673-751 (2000) 
    2. Lu G, Liao J, Yang G, Reuhl KR, Hao X, Yang CS. Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. Cancer Res. 66: 1494-1501 (2006) 
    3. Shim HY, Park JH, Paik HD, Nah SY, Kim DSHL, Han YS. Genistein-induced apoptosis of human breast cancer MCF-7 cells involves calpain-caspase and apoptosis signaling kinase 1-p38 mitogen-activated protein kinase activation cascades. Anti-Cancer Drug 18: 649-657 (2007) 
    4. Yang CS, Lambert JD, Sang S. Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch. Toxicol. 83: 11-21 (2009) 
    5. Khatib AF, Kim MY, Chung SK. Anti-inflammatory activities of Cinamomum burmanni BI. Food Sci. Biotechnol. 14: 223-227 (2005)     
    6. Seelinger G, Merfort I, Schempp CM. Anti-oxidant, antiinflammatory, and anti-allergic activities of luteolin. Planta Med. 74: 1667-1677 (2008) 
    7. Wilcox LJ, Borradaile NM, Huff MW. Antiatherogenic properties of naringenin, a citrus flavonoid. Cardiovasc. Drug Rev. 17: 160-178 (1999) 
    8. Verhoeyen ME, Bovy A, Collins G, Muir S, Robinson S, de Vos CH, Colliver S. Increasing antioxidant levels in tomatoes through modification of the flavonoids biosynthetic pathway. J. Exp. Bot. 53: 2099-2106 (2002) 
    9. Shimizu K, Ashida H, Matsuura Y, Kanazawa K. Antioxidative bioavailability of artepillin C in Brazilian propolis. Arch. Biochem. Biophys. 424: 181-188 (2004) 
    10. Shi Y, Dai J, Liu H, Li RR, Sun PL, Du Q, Pang LL, Chen Z, Yin KS. Naringenin inhibits allergen-induced airway inflammation and airway responsiveness and inhibits NF-kappaB activity in a murine model of asthma. Can. J. Physiol. Pharm. 87: 729-735 (2009) 
    11. Gangjun D, Lingtao J, Xiaofen H, Zihui S, Hongyan Z, Wei L. Naringenin: A potential immunomodulator for inhibiting lung fibrosis and metastasis. Cancer Res. 69: 3205-3212 (2009) 
    12. Kanno S, Tomizawa A, Hiura T, Osanai Y, Shouji A, Ujibe M, Ohtake T, Kimura K, Ishikawa M. Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180- implanted mice. Biol. Pharm. Bull. 28: 527-530 (2005) 
    13. Zhang FY, Du GJ, Zhang L, Zhang CL, Lu WL, Liang W. Naringenin enhances the anti-tumor effect of doxorubicin through selectively inhibiting the activity of multidrug resistance-associated proteins but not P-glycoprotein. Pharm. Res. 26: 914-925 (2008) 
    14. Kim KT, Moon SH, Park YS, Han YS, Nah SY, Lee NG, Paik HD. Inhibitory effect of 7-O-butyl naringenin on growth of Helicobacter pylori ATCC 26695. Food Sci. Biotechnol. 15: 466-468 (2006)     
    15. Moon SH, Kim KT, Lee NK, Han YS, Nah SY, Cho SG, Park YS, Paik HD. Inhibitory effects of naringenin and its derivatives on hyaluronidase. Food Sci. Biotechnol. 18: 267-270 (2009)     
    16. Cameron E, Pauling L, Leibovitz B. Ascorbic acid and cancer: A review. Cancer Res. 39: 663-681 (1979) 
    17. Jakegawa H, Matsumoto H, Satoh T. Inhibitory effects of some natural products on the activation of hyaluronidase and their antiallergic action. Chem. Pharm. Bull. 40: 1439-1442 (1999) 
    18. Shim HY, Park JH, Paik HD, Nah SY, Kim DSHL, Han YS. Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation. Mol. Cells 24: 95-104 (2007) 
    19. Harmon AW, Patel YM. Naringenin inhibits glucose uptake in MCF-7 breast cancer cells: A mechanism for impaired cellular proliferation. Breast Cancer Res. Tr. 85: 103-110 (2004) 
    20. Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascade. Adv. Cancer Res. 74: 49-139 (1998) 
    21. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298: 1911-1912 (2002) 
    22. Chen YR, Meyer CF, Tan TH. Persistent activation of c-Jun Nterminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J. Biol. Chem. 271: 631-634 (1996) 
    23. Raingeaud J, Gupta S, Rogers JS, Dicken M, Han J, Ulevitch RJ, Davis RJ. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270: 7420-7426 (1995) 
    24. Banerjee S, Zhang Y, Ali S, Bhuiyan M, Wang Z, Chiao PJ, Philip PA, Abbruzzese J, Sarkar FH. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res. 65: 9064-9072 (2005) 
    25. Bischoff SC. Quercetin: Potentials in the prevention and therapy of disease. Curr. Opin. Clin. Nutr. 11: 733-740 (2008) 
    26. Kanno S, Shouji A, Hirata R, Asou K, Ishikawa M. Effect of naringenin on cytosine arabinoside (Ara-c)-induced cytotoxicity and apoptosis in P388 cells. Life Sci. 75: 353-365 (2004) 
  • 이 논문을 인용한 문헌 (1)

    1. 2011. "" Bulletin of the Korean Chemical Society, 32(5): 1741~1744     

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