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The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology v.14 no.3, 2010년, pp.151 - 156   SCIE
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The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats

Ameer, Nasir Hussin    (Department of Physiology, Wonkwang University School of Medicine, and Brain Research Institute at Wonkwang University   ); Lee, Jae-Hee    (Department of Physiology, Wonkwang University School of Medicine, and Brain Research Institute at Wonkwang University   ); Choi, Myoung-Ae    (Department of Physiology, Wonkwang University School of Medicine, and Brain Research Institute at Wonkwang University   ); Jin, Guang-Shi    (Department of Neurosurgery, Affiliated Hospital of Yanbian University   ); Kim, Min-Sun    (Department of Physiology, Wonkwang University School of Medicine, and Brain Research Institute at Wonkwang University   ); Park, Byung-Rim    (Department of Physiology, Wonkwang University School of Medicine, and Brain Research Institute at Wonkwang University  );
  • 초록

    This study was performed to investigate the role of glutamate neurotransmitter system on gastrointestinal motility in a middle cerebral artery occlusion (MCAO) model of rats. The right middle cerebral artery was occluded by surgical operation, and intestinal transit and geometric center as a parameter of gastrointestinal motility and expression of c-Fos protein in the insular cortex and cingulate cortex were measured at 2 and 12 h after MCAO. Intestinal transit was $66.3{\pm}7.5%$ and $62.3{\pm}5.7%$ 2 and 12 h after sham operation, respectively, and MCAO significantly decreased intestinal transit to $39.0{\pm}3.5%$ and $47.0{\pm}5.1%$ at 2 and 12 h after the occlusion, respectively (p $5.6{\pm}0.4$ and $5.2{\pm}0.9$ at 2 and 12 h after sham operation, respectively, and MCAO significantly decreased geometric center to $2.9{\pm}0.8$ and $3.0{\pm}0.3$ at 2 and 12 h after the occlusion, respectively (p $35.9{\pm}5.2%$ , and injection of glutamate NMDA receptor antagonist, MK-801, decreased intestinal transit to $28.8{\pm}9.5%$ . Pretreatment with MK-801, a glutamate NMDA receptor antagonist, in the MCAO group decreased intestinal transit to $11.8{\pm}3.2%$ , which was significantly decreased compared to MCAO group (p


  • 주제어

    Glutamate .   Insular cortex .   Intestinal transit .   MCAO .   MK-801.  

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