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대한물리치료학회지 = The journal of Korean Society of Physical Therapy v.23 no.2, 2011년, pp.45 - 52   피인용횟수: 1
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흰쥐 궁둥신경 손상 후 전침에 의한 척수 내 NeuN 발현에 미치는 영향
The Effect of Electroacupuncture on NeuN Expression in Spinal Cord in Sciatic Nerve Injured Rat

조미숙    (나사렛대학교 물리치료학과  );
  • 초록

    Purpose: The purpose of this study was to investigate the effect of electroacupuncture on NeuN expression in ventral horn motor neurons of spinal cord, changes in pain thresholdchanges in motor function in rats with partially dissected sciatic nerves. Method: A total of 120 male Sprague-Dawley rats were randomly divided into two groups, a control group and a group administered electroacupuncture at ST36, LI11 and SP9 with 120 Hz and 0.5 mA. Animals were sacrificed on days 1, 3, 7, 14 and 28 after nerve injury (the sciatic nerve was partially dissected). The pain threshold was recorded by an Analgesia? meter and a BBB? score was calculated for motor function. After preparing lumbar spinal cord slide sections, they were immunostained with NeuN antisera (1:2,500). Results: The numbers of NeuN immunoreactive neuronsin the electroacupuncture group was increased compared to the control group. The numbers of NeuN immunoreactive neurons on days 14 and 28 day were different (p


  • 주제어

    Electroacupuncture .   Pain .   NeuN .   Ventral horn .   Spinal cord .   BBB score.  

  • 참고문헌 (28)

    1. Beattie MS, Hermann GE, Rogers RC et al. Cell death in models of spinal cord injury. Prog Brain Res. 2002;137:37-47. 
    2. Bowenkamp KE, David D, Lapchak PL et al. 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor. Exp Brain Res. 1996;111(1):1-7. 
    3. Lamond AI, Spector DL. Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol. 2003;4(8):605-12. 
    4. Mori F, Himes BT, Kowada M et al. Fetal spinal cord transplants rescue some axotomized rubrospinal neurons from retrograde cell death in adult rats. Exp Neurol. 1997;143(1):45-60. 
    5. Wolf HK, Buslei R, Schmidt-Kastner R et al. NeuN: a useful neuronal marker for diagnostic histopathology. J Histochem Cytochem. 1996;44(10):1167-71. 
    6. Unal-Cevik I, KilincM, Gursoy-Ozdemir Y et al. Loss of NeuN immunoreactivity after cerebral ischemia does not indicate neuronal cell loss: a cautionary note. Brain Res. 2004;1015(1-2):169-74. 
    7. Schmidt-Kastner R. Robertson GS, Hakim A et al. Monoclonal antibody to NeuN as specific marker for neurons in immunohistochemical evalua- tion of global ischemic damage in rat. J Cerebr Blood Flow Metab. 1995;15(Suppl 1):S230. 
    8. Nickerson J. Experimental observations of a nuclear matrix. J Cell Sci. 2001;114(Pt 3):463-74. 
    9. McPhail LT, McBride CB, McGraw J et al. Axotomy abolishes NeuN expression in facial but not rubrospinal neurons. Exp Neurol. 2004;185(1):182-90. 
    10. Lind D, Franken S, Kappler J et al. Characterization of the neuronal marker NeuN as a multiply phosphorylated antigen with discrete subcellular localization. J Neurosci Res. 2005;79(3):295-302. 
    11. Kim YI, Kim YH, Lim YK et al. A fMRI study on the cerebral activity induced by electro-acupuncture on Zusanli(St36). J Kor Acup Moxi Soci. 2003;20(5):133-50. 
    12. Son IS, Choi BT, Jang KJ. The effects of 120Hz electroacupuncture on the prostaglandin E2 and spinal N-Methyl-D-Aspartate receptor expression in the carrageenan -injected rat. J Kor Acup Moxi Soci. 2002;19(1);159-74. 
    13. Kim JT, Lee JD, Lee YH. Effect of different patterns of low frequency electroacupuncture on the neuronal activities in the spinal cord and brainstem using fos immunohistochemical technique. J Kor Acup Moxi Soci. 1999(2):402-22. 
    14. Ryu. SR, Baek YH, Park DS. The analgesic effect and its mechanism of electroacupuncture in the type II collageninduced arthritis rat: mediation by serotonergic receptors. J Kor Acup Moxi Soci. 2006;23(3):77-90.     
    15. Kim GY, Woo KH. The effects of alphabet exercise with SSP electrotherapy on lateral ankle sprain. J Kor Soci Phy The. 2004;16(2):323-31.     
    16. Lee KM, Kim KS, Cheon MN et al. Long term effects of electrical acupuncture treatment on rat's spinal cord and allodynia. J Kor Acup Moxi Soci. 1997;14(1):287-302. 
    17. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29(4):577-80. 
    18. Block ML, Hong JS. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol. 2005;76(2):77-98. 
    19. Ryu. SR, Baek YH, Park DS. The analgesic effect and its mechanism of electroacupuncture in the type II collageninduced arthritis rat: mediation by serotonergic receptors. J Kor Acup Moxi Soci. 2006;23(3):77-90.     
    20. Kwon BK, Liu J, Oschipok L et al. Reaxotomy of chronically injured rubrospinal neurons results in only modest cell loss. Exp Neurol. 2002;177(1):332-7. 
    21. Block ML, Hong JS. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol. 2005;76(2):77-98. 
    22. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29(4):577-80. 
    23. Kim KK, Adelstein RS, Kawamoto S. Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. J Biol Chem. 2009;284(45):31052-61. 
    24. Salehi-Ashtiani K, Farbman AI. Expression of neu and Neu differentiation factor in the olfactory mucosa of rat. Int J Dev Neurosci. 1996;14(7-8):801-11. 
    25. Chuang CM, Hsieh CL, Li TC et al. Acupuncture stimulation at Baihui acupoint reduced cerebral infarct and increased dopamine levels in chronic cerebral hypoperfusionand ischemia-reperfusion injured sprague-dawley rats. Am J Chin Med. 2007;35(5):779-91. 
    26. Gan P, Cheng JS, Ng YK et al. Role of GABA in electro-acupuncture therapy on cerebral ischemia induced by occlusion of the middle cerebral artery in rats. Neurosci Lett. 2005;383(3):317-21. 
    27. Uchida S, Kagitani F, Suzuki A et al. Effect of acupuncture-like stimulation on cortical cerebral blood flow in anesthetized rats. Jpn J Physiol. 2000;50(5):495-507. 
    28. Hjorth S. Serotonin 5-HT1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study. J Neurochem. 1993;60(2):776-9. 
  • 이 논문을 인용한 문헌 (1)

    1. Song, Ju-Min 2011. "Localization of Amygdaloid Nucleus Innervating the Stomach Using Genetically Engineered PRV-BaBlu in Rat Brain" 대한물리치료학회지 = The journal of Korean Society of Physical Therapy, 23(5): 35~41     

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