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한국임상약학회지 = Korean journal of clinical pharmacy v.21 no.1, 2011년, pp.22 - 29  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Physician's Desk Reference에 나타난 성별차이 분석
Analysis of Gender Differences in Physician's Desk Reference

허정선    (이화여자대학교 임상보건과학대학원   ); 김경희    (이화여자대학교 약학대학/생명약학부   ); 윤인경    (이화여자대학교 약학대학/생명약학부   ); 김현주    (이화여자대학교 약학대학/생명약학부   ); 김유진    (이화여자대학교 약학대학/생명약학부   ); 최종민    (이화여자대학교 약학대학/생명약학부   ); 이병구    (이화여자대학교 약학대학/생명약학부   ); 이화정    (이화여자대학교 약학대학/생명약학부   ); 곽혜선    (이화여자대학교 약학대학/생명약학부  );
  • 초록

    Purpose: This study aims to investigate how gender-based differences are actually reflected on drug approval. Methods: Data on gender-based differences of drugs were analyzed by searching PDR (Physician's Desk Reference) with the keyword, "GENDER". Results: There were descriptions related to gender in product directions of 361 drugs in 2009 PDR, out of which 63 items actually showed gender-related differences. Drug categories showing comparatively high gender-based differences were nervous system, cardiovascular system, and alimentary tract and metabolism. Pharmacokinetic differences between genders were observed most frequently; compared to men, 32 drugs showed higher absorption while 18 drugs revealed lower clearance in women. There were 2 drugs which gender should be considered before prescribing, and 5 drugs which showed different severity of adverse effects according to gender. Conclusions: It is necessary to establish domestic policies for drug approval and use which reflects gender-based differences through sufficient researches.


  • 주제어

    Gender-based differences .   Physician's Desk Reference .   Drug approval.  

  • 참고문헌 (20)

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