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Food science and biotechnology v.20 no.1, 2011년, pp.79 - 84   SCIE SCOPUS 피인용횟수: 1
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Tyrosine-fortified Silk Amino Acids Improve Physical Function of Parkinson's Disease Rats

Kim, Tae-Kyun    (College of Veterinary Medicine, Chungbuk National University   ); Park, Dong-Sun    (College of Veterinary Medicine, Chungbuk National University   ); Yeon, Seong-Ho    (Worldway Co., Ltd.   ); Lee, Sun-Hee    (College of Veterinary Medicine, Chungbuk National University   ); Choi, Young-Jin    (College of Veterinary Medicine, Chungbuk National University   ); Bae, Dae-Kwon    (College of Veterinary Medicine, Chungbuk National University   ); Yang, Yun-Hui    (College of Veterinary Medicine, Chungbuk National University   ); Yang, Goeun    (College of Veterinary Medicine, Chungbuk National University   ); Joo, Seong-Soo    (Division of Marine Molecular Biotechnology, Gangneung-Wonju National University   ); Lim, Woo-Taek    (Worldway Co., Ltd.   ); Lee, Jeong-Yong    (Worldway Co., Ltd.   ); Lee, Joon-Soo    (Department of Food Science and Technology, Chungbuk National University   ); Jeong, Heon-Sang    (Department of Food Science and Technology, Chungbuk National University   ); Hwang, Seock-Yeon    (Department of Biomedical Laboratory Science, Daejeon University   ); Kim, Yun-Bae    (College of Veterinary Medicine, Chungbuk National University  );
  • 초록

    Physical function-improving effects of a silk amino acid preparation (SAA) in Parkinson's disease (PD) model rats were investigated. 6-Hydroxydopamine (6-OHDA, $8{\mu}g$ )+ascorbic acid ( $0.6{\mu}g$ ) was injected into right medial forebrain bundle of 8-week-old Sprague-Dawley rats to induce PD, and SAA (50, 160, or 500 mg/kg) was orally administered for 30 days. On day 15 and 30, behavioral abnormalities, neuronal loss, and dopamine and its metabolites were analyzed. Injection of 6-OHDA impaired pole test performances, which were markedly improved by treatment with SAA. Increased using rate of ipsilateral (normal) forelimb in cyclinder test and apomorphine (0.05 mg/kg)-induced circling behavior of PD rats were remarkably corrected by the compounds. In addition, 6-OHDAinduced loss of neurons as well as decreases in dopamine and its metabolites were significantly attenuated by SAA. The results indicate that SAA preserves movement function of PD model animals by protecting dopamine neurons against 6-OHDA neurotoxicity.


  • 주제어

    silk amino acid .   tyrosine .   Parkinson's disease .   physical function .   neuroprotection.  

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  • 이 논문을 인용한 문헌 (1)

    1. 2011. "" Biomolecules & therapeutics, 19(2): 224~230     

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