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大韓韓醫學會誌 = Journal of Korean Oriental Medicine v.32 no.2, 2011년, pp.63 - 78   KCI 피인용횟수: 4
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Elastase 매개성 폐조직 손상에 대한 맥문동탕(麥門冬湯)의 보호효과
Protective Effects of Maekmundong-tang on Elastase-induced Lung Injury

김형원   (대전대학교 한의과대학 폐계내과학교실  ); 양수영   (대전대학교 한의과대학 폐계내과학교실  ); 김민희   (대전대학교 한의과대학 신경생리학교실  ); 남궁욱   (대전대학교 한의과대학 신경생리학교실  ); 박양춘   (대전대학교 한의과대학 폐계내과학교실  );
  • 초록

    Objective: This study aimed to evaluate the protective effects of Maekmundong-tang (MMDT) on an elastase-induced COPD model. Materials and Methods: The extract of MMDT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: MMDT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of Cdk1, and gene expression of TNF- ${\alpha}$ and IL- $1{\beta}$ in A549 cells. MMDT treatment also revealed a protective effect on the elastase-induced COPD mice model. This effect was evidenced via histopathological finding including immunofluorescence stains against elastin, collagen, and caspase 3, and protein level of Cdc2 in lung tissue. Conclusion: These data suggest that MMDT has pharmaceutical properties on COPD. This study can provide scientific evidence for the efficacy of MMDT for clinical application to patients with COPD.


  • 주제어

    Maekmundong-tang (Maimendong-tang) .   chronic obstructive pulmonary disease .   A549 cell .   elastase.  

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  • 이 논문을 인용한 문헌 (4)

    1. Park, Dong-Il 2013. "Effects of Maekmundong-tang on the Improvement of Lung Capacity" 大韓韓醫學方劑學會誌 = Herbal formula science, 21(2): 165~172     
    2. Oh, Ji-Seok ; Yang, Su-Young ; Kim, Min-Hee ; Namgung, Uk ; Park, Yang-Chun 2013. "Effects of Root of Curcumin longa on LPS-induced Lung Injury" 大韓韓醫學會誌 = Journal of Korean Oriental Medicine, 34(1): 89~102     
    3. Park, Ji-Young 2014. "The impact of Health Status of for the Elderly on Oral Health-Related of life Quality" 디지털융복합연구 = Journal of digital convergence, 12(5): 271~280     
    4. Kwon, Young-Ok ; Choi, Mi-Sook ; Lee, Jong-Hwa ; Yun, Hyun-Kyung 2014. "Analysis of structural relationship among geriatric denture-related characteristics, denture satisfaction, and GOHAI" 디지털융복합연구 = Journal of digital convergence, 12(4): 399~407     

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