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大韓韓醫學會誌 = Journal of Korean Oriental Medicine v.32 no.4, 2011년, pp.83 - 99   KCI 피인용횟수: 4
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Elastase로 유도된 폐손상에 대한 소청룡탕(小靑龍湯)의 보호효과
Protective Effects of Socheongryong-tang on Elastase-Induced Lung Injury

이주관   (대전대학교 한의과대학 폐계내과학교실  ); 양수영   (대전대학교 한의과대학 폐계내과학교실  ); 김민희   (대전대학교 한의과대학 신경생리학교실  ); 남궁욱   (대전대학교 한의과대학 신경생리학교실  ); 박양춘   (대전대학교 한의과대학 폐계내과학교실  );
  • 초록

    Objective: This study aimed to evaluate the protective effects of Socheongryong-tang (SCRT) on elastase-induced lung injury. Materials and Methods: The extract of SCRT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: SCRT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, and gene expression of TNF- ${\alpha}$ and IL- $1{\beta}$ in A549 cells. SCRT treatment also revealed the protective effect on elastase-induced COPD mice model. This effect was evidenced via histopathological findings including immunofluoresence stains against elastin, collagen, and caspase 3, and protein level of Cdc2, cyclin B1, and phospho-Erk1/2 in lung tissue. Conclusion: These data suggest that SCRT has pharmaceutical properties on COPD. This study provides scientific evidence for the efficacy of SCRT for clinical application to patients with COPD.


  • 주제어

    Socheongryong-tang .   chronic obstructive pulmonary disease .   A549 cell .   elastase.  

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  • 이 논문을 인용한 문헌 (4)

    1. Kim, Jung-Hoon ; Shin, Hyeun-Kyoo 2012. "Analysis of Biological Experiment on Socheongryong-tang (Xiaoqinglong-tang)" 大韓韓醫學會誌 = Journal of Korean Oriental Medicine, 33(3): 54~73     
    2. Lee, Eung-Seok ; Han, Jong-Min ; Kim, Min-Hee ; Namgung, Uk ; Yeo, Yoon ; Park, Yang-Chun 2013. "Effects of Inhalable Microparticles of Socheongryong-tang on Chronic Obstructive Pulmonary Disease in a Mouse Model" Journal of Korean Medicine = 대한한의학회지, 34(3): 54~68     
    3. Oh, Ji-Seok ; Yang, Su-Young ; Kim, Min-Hee ; Namgung, Uk ; Park, Yang-Chun 2013. "Effects of Root of Curcumin longa on LPS-induced Lung Injury" 大韓韓醫學會誌 = Journal of Korean Oriental Medicine, 34(1): 89~102     
    4. Han, Jong-Min ; Yang, Won-Kyung ; Kim, Seung-Hyeong ; Park, Yang-Chun 2015. "Effects of Sagan-tang and individual herbs on COPD Mice Model" 大韓韓醫學方劑學會誌 = Herbal formula science, 23(2): 171~187     

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