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Journal of the Korean Association of Oral and Maxillofacial Surgeons v.38 no.2, 2012년, pp.90 - 95  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Prophylactic antibiotics in intra-oral bone grafting procedures: a prospective, randomized, double-blind clinical trial

Lee, Jung-Woo    (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University   ); Lee, Jin-Yong    (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University   ); Kim, Soung-Min    (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University   ); Kim, Myung-Jin    (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University   ); Lee, Jong-Ho    (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University  );
  • 초록

    Objectives: This study was conducted in order to assess the efficacy of 1st generation cephalosporin as use as a single-dose preoperative prophylactic antibiotic for surgical wound infections resulting from intra-oral bone grafting procedures. Materials and Methods: A total of 23 patients who were to undergo intra-oral bone graft procedures participated in this study. After randomization, 2 grams of 1st generation cephalosporin was orally administered to both the experimental and placebo groups one hour prior to surgery in a double-blind fashion. Post-operatively, the experimental group (12 patients) was orally administered placebo three times a day for three days. The control group (11 patients) was orally administered 1st generation cephalosporin three times a day for three days. The postoperative course was observed for one month including the clinical parameters associated with infection. Results: Postoperative infections were noted in 1 out of 11 patients in the experimental group. No infections occurred in the control group. Conclusion: There was no significant difference in the incidence of postoperative infections between the two groups. Two grams of 1st generation cephalosporin administered orally one hour before surgery served as an effective prophylactic antibiotics therapy for intra-oral bone graft surgery.


  • 주제어

    Intra-oral bone graft .   Prophylactic antibiotics .   Surgical site infection.  

  • 참고문헌 (12)

    1. Kang SH, Choi YS, Byun IY, Kim MK. Antibiotic prophylaxis in the operation of the closed mandibular fractures and the efficacy of postoperative antibiotics. J Korean Assoc Oral Maxillofac Surg 2009;35:31-4. 
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    3. Ko JK, Cho YK, Yang HJ, Park CW, Park JS, Jun JK, et al. A prospective multicenter randomized study on prophylactic antibiotics use in cesarean section performed at tertiary center. Korean J Obstet Gynecol 2010;53:227-34. 
    4. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, et al; American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee; American Heart Association Council on Cardiovascular Disease in the Young; American Heart Association Council on Clinical Cardiology; American Heart Association Council on Cardiovascular Surgery and Anesthesia; Quality of Care and Outcomes Research Interdisciplinary Working Group. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 2007;116:1736-54. 
    5. Tong DC, Rothwell BR. Antibiotic prophylaxis in dentistry: a review and practice recommendations. J Am Dent Assoc 2000;131:366-74. 
    6. Alrashdan M, Choung HU, Pang KM, Park JC, Kim SM, Kim MJ, et al. Literature review of antibiotics prescription in general dental and oral-maxillofacial surgical practice. J Korean Assoc Oral Maxillofac Surg 2009;35:164-9. 
    7. Monaco G, Staffolani C, Gatto MR, Checchi L. Antibiotic therapy in impacted third molar surgery. Eur J Oral Sci 1999;107:437-41. 
    8. Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med 1992;326:281-6. 
    9. Poeschl PW, Eckel D, Poeschl E. Postoperative prophylactic antibiotic treatment in third molar surgery--a necessity? J Oral Maxillofac Surg 2004;62:3-8. 
    10. Monaco G, Staffolani C, Gatto MR, Checchi L. Antibiotic therapy in impacted third molar surgery. Eur J Oral Sci 1999;107:437-41. 
    11. Lindeboom JA, Frenken JW, Tuk JG, Kroon FH. A randomized prospective controlled trial of antibiotic prophylaxis in intraoral bone-grafting procedures: preoperative single-dose penicillin versus preoperative single-dose clindamycin. Int J Oral Maxillofac Surg 2006;35:433-6. 
    12. Lindeboom JA, van den Akker HP. A prospective placebo-controlled double-blind trial of antibiotic prophylaxis in intraoral bone grafting procedures: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;96:669-72. 

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