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Progress in superconductivity v.13 no.3, 2012년, pp.139 - 145  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

SQUID를 이용한 심자도 기술의 개발동향
Review of Magnetocardiography Technology based on SQUIDs

이용호    (Brain and Cognition Measurement Lab, Korea Research Institute of Standards and Science   ); 권혁찬    (Brain and Cognition Measurement Lab, Korea Research Institute of Standards and Science   ); 김진목    (Brain and Cognition Measurement Lab, Korea Research Institute of Standards and Science   ); 김기웅    (Brain and Cognition Measurement Lab, Korea Research Institute of Standards and Science   ); 유권규    (Brain and Cognition Measurement Lab, Korea Research Institute of Standards and Science   ); 박용기    (Brain and Cognition Measurement Lab, Korea Research Institute of Standards and Science  );
  • 초록

    Electric activity of cardiac muscles generates magnetic fields. Magnetocardiography (or MCG) technology, measuring these magnetic signals, can provide useful information for the diagnosis of heart diseases. It is already about 40 years ago that the first measurement of MCG signals was done by D. Cohen using SQUID (superconducting quantum interference device) sensor inside a magnetically shielded room. In the early period of MCG history, bulky point-contact RF-SQUID was used as the magnetic sensor. Thanks to the development of Nb-based Josephson junction technology in mid 1980s and new design of tightly-coupled DC-SQUID, low-noise SQUID sensors could be developed in late 1980s. In around 1990, several groups developed multi-channel MCG systems and started clinical study. However, it is quite recent years that the true usefulness of MCG was verified in clinical practice, for example, in the diagnosis of coronary artery disease. For the practical MCG system, technical elements of MCG system should be optimized in terms of performance, fabrication cost and operation cost. In this review, development history, technical issue, and future development direction of MCG technology are described.


  • 주제어

    magnetocardiography .   heart disease .   SQUID .   SQUID electronics .   pickup coil .   magnetic shielding.  

  • 참고문헌 (12)

    1. D. Cohen, E. A. Edelsack and J. E. Zimmerman, "Magnetocardiograms taken inside a shielded room with superconducting point-contact magnetometer", Appl. Phys. Lett., 19, 278 (1970). 
    2. I. Tavarozzi, S. Comani, C. Dell Gratta, G. L. Romani, S. Di Luzio, D. Brisinda, S. Gallina, M. Zimarino, R. Fenici, R. De Caterina, "Magnetocardiography: current status and perspectives. Part I: Physical principles and instrumentation", Ital. Heart J., 3, 75-85 (2002). 
    3. H. Nowak, "Magnetism in Medicine", ed W. Andra and H. Nowak, Berlin: Wiley, 85-135 (1998). 
    4. R. Fenici, D. Brisinda and A. M. Meloni, "Clinical application of magnetocardiography", Expert Rev. Mol. Diagn. 5, 291-313 (2005). 
    5. S. Yamada S and I. Yamaguchi, "Magnetocardiograms in Clinical Medicine: Unique Information on Cardiac Ischemia, Arrhythmias, and Fetal Diagnosis", Internal Medicine, 44, 1-19 (2005). 
    6. J. W. Park and F. Jung, "Qualitative and quantitative description of myocardial ischemia by means of magnetocardiography", Biomed. Technik. 49, 267-273 (2004). 
    7. 이용호 외, "생체자기신호 측정 및 분석기술 개발에 관한 연구", 한국표준과학연구원보고서, 22-27 (2007). 
    8. 이용호, 김진목, 유권규, 김기웅, 권혁찬, "심자도 측정을 위한 SQUID 센서 기술의 개발 현황", Prog. Supercond., 13, 1-6 (2011).     
    9. D. Drung, "SQUID Sensors: Fundamentals, Fabrication and Applications", ed H. Weinstock, Dordrecht: Kluwer, pp 63-116 (1996). 
    10. Y. H. Lee, K. K. Yu, J. M. Kim, H. Kwon, K. Kim and Y. K. Park, "64-channel second-order axial gradiometer system based on DROS for magnetocardiogram in a thin shielded room", Physica C, 468, 1942-1945 (2008). 
    11. K. Sternikel and A. I. Braginski, "Biomagnetism using SQUIDs: status and perspectives", Supercond. Sci. Technol., 14, 160-171 (2006). 
    12. Y. H. Lee, K. K. Yu, J. M. Kim, H. Kwon and K. Kim, "A 64-channel MCG system having divided gradiometer array inside a low boil-off dewar", Supercond. Sci. Technol., 22, 1-7 (2009). 

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