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Natural product sciences v.18 no.1, 2012년, pp.1 - 7   피인용횟수: 1

Study on DPPH Free Radical Scavenging and Lipid Peroxidation Inhibitory Activities of Vietnamese Medicinal Plants

Phan, Thi Anh Dao    (Faculty of Chemistry and Food, University of Technical Education Hochiminh City   ); Nguyen, Xuan Hai    (Faculty of Chemistry, University of Science, National University Hochiminh City   ); Nguyen, Trung Nhan    (Faculty of Chemistry, University of Science, National University Hochiminh City   ); Tran, Le Quan    (Faculty of Chemistry, University of Science, National University Hochiminh City   ); Nguyen, Thi Thanh Mai    (Faculty of Chemistry, University of Science, National University Hochiminh City  );
  • 초록

    Among 90 Vietnamese medicinal plant extracts investigated for their antioxidant activity by DPPH assay at various concentrations from $10-100{\mu}g/mL$ , 67 showed an inhibition rate over 50% at $100{\mu}g/mL$ ; 47 had greater than 50% inhibition at $50{\mu}g/mL$ ; 17 showed over 50% inhibition at $25{\mu}g/mL$ . 8 extracts which exhibited strong inhibitory activity more than 50% inhibition at $10{\mu}g/mL$ were further tested for lipid peroxidation inhibition by TBA assay. They displayed activity with $IC_{50}$ values from 30.6 to $158.9{\mu}g/mL$ . Until now, this is the first report on antioxidant activity of the female flower of Borassus flabellifer, and the stem of Combretum latifolium, Embelia ribes, Spatholobus parviflorus, and Tetrastigma erubescens. Fractionations of the EtOAc extract prepared from S. parviflorus led to the isolation of protocatechuic acid (1), ferulic acid (2), epicatechin (3), and gallic acid (4). These compounds showed significant DPPH inhibitory activity with $IC_{50}$ values from 6.5 to $23.6{\mu}M$ .


  • 주제어

    Vietnamese medicinal plant .   Antioxidant activity .   DPPH .   Lipid peroxidation .   Spatholobus parviflorus.  

  • 참고문헌 (13)

    1. Alvarez-Suarez, M.J., Tulipani, S., Romandini, S., Vidal, A., and Battino, M., Methodological aspects about determination of phenolic compounds and in vitro evaluation of antioxidant capacity in the Honey: A Review. Current Analytical Chemistry. 5, 293-302 (2009). 
    2. Ban, Y.J., Jeon, Y.S., Bae, K., Song, S. K., Seong, Y., Catechin and epicatechin from Smilacis chinae rhizome protect cultured rat cortical neurons against amyloid $\beta$ protein (25-35)- induced neurotoxicity through inhibitory of cytosolic calcium elevation. Life Sciences. 79, 2251-2259 (2006). 
    3. Beohm, V., Schlesier, K., Harwat, M., and Bitsch, R., Comparison of different in vitro methods to evaluate the antioxidant activity with ascorbic acid, gallic acid, Trolox_and uric acid as standard antioxidants. In W. Pfannhauser GR Frenwick, Khokhar S (Eds.), Biological-active phytochemicals in food: Analysis, metabolism, bioactivation and function. Royal Society of Chemistry. 296-299 (2001). 
    4. Do, H, B., Vietnamese medicinal plants and animals. Science and Technology publisher. Ha Noi, 2004. 
    5. Do, T.L., Vietnamese medicinal plants. Medicinine publisher. Ha Noi, 2009. 
    6. Donia, M.R.E.A., Alqasoumi, I.S., Awaad, S.A., and Cracker, L., Antioxidant activity of Covolvulus hystrix Vahl and its chemical constituents. Pakistan Journal of Pharmaceutical Sciences. 24, 143- 147 (2011). 
    7. Karamac, M., Kosinska, A., and Pegg, B.R., Comparision of radicalscavenging activities for selected phenolic acids. Polish Journal of Food and Nutrition Sciences. 14, 165-170 (2005). 
    8. Molyneux, P., The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin Journal of Science and Technology. 26, 211-219 (2004). 
    9. Nagulendran, Kr., Velavan, K., Mahesh, R., and Hazeena Begum, V., In vitro antioxidant activity and total polyphenolic content of Cyperus rotundus Rhizomes. E-Journal of Chemistry. 4, 440-449 (2007). 
    10. Pandey, M., Sonker, K., Kanoujia, J., Koshy, K.M., and Saraf, S.A., Sida Veronicaefolia as a source of natural antioxidant. International Journal of Pharmaceutical Sciences and Drug Research. 1, 180-182 (2009). 
    11. Singh, R. and Arora, S., Attenuation of free radicals by acetone extract / fractions of Acacia nilotica L.) WilldADEx del. Journal of Chinese Clinical Medicine. 2, 196-204 (2007). 
    12. Yilmaz, Y., and Toledo, R.T., Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid, Journal of Agricultural and Food Chemistry. 52, 255-260 (2004). 
    13. Zhang, Z., Liao, L., Moore, J., Wu, T., Wang, Z., Antioxidant phenolic compounds from walnut kernels (Juglans regia L.). Food Chemistry. 113, 160-165 (2009). 
  • 이 논문을 인용한 문헌 (1)

    1. 2014. "" Natural product sciences, 20(1): 22~28     

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