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Natural product sciences v.18 no.1, 2012년, pp.47 - 51  

Screening of ${\alpha}$-Glucosidase Inhibitory Activity of Vietnamese Medicinal Plants : Isolation of Active Principles from Oroxylum indicum

Nguyen, Mai Thanh Thi    (Faculty of Chemistry, University of Science, Vietnam National University   ); Nguyen, Nhan Trung    (Faculty of Chemistry, University of Science, Vietnam National University   ); Nguyen, Hai Xuan    (Faculty of Chemistry, University of Science, Vietnam National University   ); Huynh, Thuy Nghiem Ngoc    (Faculty of Chemistry, University of Science, Vietnam National University   ); Min, Byung-Sun    (College of Pharmacy, Catholic University of Daegu  );
  • 초록

    Among 38 Vietnamese medicinal plant extracts investigated for their ${\alpha}$ -glucosidase inhibitory activity, 35 extracts showed $IC_{50}$ values below $250{\mu}g/mL$ . The MeOH extracts of the heartwood of Oroxylum indicum, the seeds of Caesalpinia sappan, and the fruits of Xanthium strumarium exhibited strong ${\alpha}$ -glucosidase inhibitory activity with $IC_{50}$ values less than $50{\mu}g/mL$ . Fractionation of the MeOH extract of the heartwood of O. indicum led to the isolation of oroxylin A (1), oroxyloside (2), hispidulin (3), apigenin (4), ficusal (5), balanophonin (6), 2- (1-hydroxymethylethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione (7), salicylic acid (8), p-hydroxybenzoic acid (9), protocatechuic acid (10), isovanillin (11), and ${\beta}$ -hydroxypropiovanillon (12). Compounds 1 - 3, 5, 6, 8, 10, and 12 showed more potent activities, with $IC_{50}$ values ranging from 2.13 to $133.51{\mu}M$ , than a positive control acabose ( $IC_{50}$ , $241.85{\mu}M$ ). The kinetic study indicated that oroxyloside (2) displayed mixed-type inhibition with inhibition constant (Ki) was $3.56{\mu}M$ .


  • 주제어

    Vietnamese medicinal plants .   ${\alpha}$-glucosidase inhibitory activity .   Oroxylum indicum.  

  • 참고문헌 (19)

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