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생약학회지 v.43 no.1 = no.168, 2012년, pp.27 - 31   피인용횟수: 2

엉겅퀴 뿌리 및 꽃 추출물의 간 성상세포 활성 억제 효과
Inhibitory Effect of Cirsium japonicum Root or Flower Extract on Hepatic Stellate Cells Activation

김상준    (전주생물소재연구소   ); 김선영    (전주생물소재연구소   ); 김지애    (전주생물소재연구소   ); 박인선    (전주생물소재연구소   ); 유강열    (전주생물소재연구소   ); 정창호    (전주생물소재연구소   ); 심재석    (임실생약조합   ); 장선일    (전주대학교 대체의학대학   ); 정승일    (전주생물소재연구소  );
  • 초록

    This study was designed to elucidate the effects of Cirsium japonicum (CJ) extracts on hepatic stellate cells (HSCs, LX-2 cells) proliferation, which is induced by platelet-derived growth factor (PDGF) or transforming growth factor- ${\beta}$ (TGF- ${\beta}$ ). The content of total phenol, flavonoid, and silymarin derivatives was more higher in CJ-flower than in CJ-root. Consistent with these results, the LX-2 cells growth inhibition was more effective in CJ-flower extract than in CJ-root extract, the complete growth inhibition concentration was $1{\mu}g/mL$ and $50{\mu}g/mL$ , respectively. These results suggest that extracts from CJ-flower can be potentially used as therapeutic substances for the regulatioin of HSCs activation.


  • 주제어

    Cirsium japonicum .   Hepatic stellate cells .   LX-2 cells .   Liver fibrosis .   Silymarin.  

  • 참고문헌 (16)

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    3. Chung, M. S., Um, H. J., Kim, C. K. and Kim, G. H. (2007) Development of functional tea product using Circium japoinucum. Korean J. Food Culture 22: 261-265. 
    4. Park, J. C., Hur, J. M., Park J. G., Kim S. C., Park, I. R., Choi, S. H. and Choi, J. W. (2004) Effects of methanol extract of Cirsium japonicum var. ussurense and its principle, hipidulin- 7-O-neohesperidoside on hepatic alchohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats. Phytother. Res. 18: 19-24. 
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    6. Tsukada, S., Parosns, C. J. and Ripe, R. A. (2006) Mechanism of liver fibrosis. Clin. Chim. Acta. 364: 33-60. 
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    14. Moreno, M. I. N., Isla, M. I. N., Sampietro, A. R. and Vattuone, M. A. (2000) Comparison of the free radical-scavenging activity of propolis from several region of Argentina. J. Ethnopharmacol. 71: 109-114. 
    15. Liu, H., Du, Z. and Yuan, Q. (2009) A novel rapid method for simultaneous determination of eight active compounds in silymarin using reversed-phased UPLC-UV detector. J. Chromatogr. B. 877: 4159-4163. 
    16. Vogel, G., Trost, W. and Braatz, R. (1975) Studies on the pharmacodynamics, including site and mode of action of silymarin: The antihepatotoxic principle from Silybum mar (L) Gaertn. Arzeiittelforsch 25: 2-9. 
  • 이 논문을 인용한 문헌 (2)

    1. Kim, Seon-Young ; Kim, Sang-Jun ; Choi, Young Ji ; Yu, Kang-Yeol ; Chung, Chang-Ho ; Shim, Jae-Suk ; Jang, Seon-Il ; Yu, Dong-Hyun ; Jeong, Seung-Il 2013. "Analysis of Active Components in Cirsium japonicum var. ussuriense Extracts and Their Effect on TGF-beta Induced Hepatic Stellate Cells Activation" 생약학회지, 44(2): 110~117     
    2. Jang, Miran ; Park, Hyejin ; Hong, Eunyeong ; Kim, Gun-Hee 2014. "Comparison of the Antibacterial Activity of Domestic Cirsium japonicum Collected from Different Regions" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 30(3): 278~283     

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