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생약학회지 v.43 no.1 = no.168, 2012년, pp.46 - 53  

수치에 의한 생약의 항산화 활성 및 성분 변화
Changes of Antioxidant Activity and Ingredient in Medicinal Plants by Processing

차배천    (상지대학교 보건과학대학 제약공학과   ); 전경수    (상지대학교 보건과학대학 제약공학과  );
  • 초록

    This study was conducted to investigate the change of antioxidant activity and ingredient in 4 species medicinal plant by processing. As a result, EtOAc extract and n-BuOH extract obtained from Cistanche deserticola Y. C. Ma and processed Cistanche deserticola Y. C. Ma showed difference on the experiment of antioxidant activity by DPPH method. Change of ingredient also was confirmed by TLC and HPLC analyses. Two main compounds of antioxidant activity change were isolated by column chromatography from the EtOAc extract and n-BuOH extract of Cistanche deserticola Y. C. Ma. The chemical structure of the compound 1 isolated from EtOAc extract of Cistanche deserticola Y. C. Ma was elucidated as 2'-acetylacteoside by means of IR and NMR analyses. Also, the chemical structure of the compound 2 isolated from n-BuOH extract of Cistanche deserticola Y. C. Ma was confirmed as acteoside. The antioxidant activity of processed Cistanche deserticola Y. C. Ma. was declined by 3 time decrements of 2'-acetylacteoside such as 1.89 mg/g to 0.62 mg/g and 2 time decrements of acteoside such as 5.81 mg/g to 2.67 mg/g by processing.


  • 주제어

    Processing .   Change .   Antioxidant activity .   DPPH .   HPLC .   Cistanche deserticola .   2'-Acetylacteoside .   Acteoside.  

  • 참고문헌 (28)

    1. Kitagawa, I., Chen, Z. L., Yoshihara, M., Kobayashi, K., Yoshikawa, M., Ono, N. and Yoshimura, Y. (1984) Chemical studies on crude drug processing. III. Aconiti tuber (2). On the constituents of pao-fuzi, the processed tuber of Aconitum carmichaeli Debx, and biological activities of lipo-alkaloids. Yakugaku Zasshi 104: 858-866. 
    2. Park, S. Y., Chung, B. S., Lee, H. K., Lee, H. S. and Ryu, J. H. (1989) Studies on the preparation of processed Aconiti tubers. Kor. J. Pharmacogn. 20: 25-31. 
    3. Kitagawa, I., Fukuda, Y., Taniyama, T. and Yoshikawa, M. (1991) Chemical studies on crude drug processing. VII. On the constituents of Rehmanniae Radix.(1) : Absolutes stereostructures of rehmaglutins A, B, and D isolated from chines Rehmanniae Radix, the dried root of Rehamannia glutinosa Libosch. Chem. pharm. Bull., 39: 1171-1176. 
    4. Lee, J. H., Koh, J. A., Hwang, E. Y. and Hong, S. P. (2002) Quantitative determination of 5-hydroxymethyl-2-furaldehyde from Rehmanniae Radix preparata according to various processings. Kor. J. Herbology 17: 145-149. 
    5. Kim, N. J. and Hong, N. D. (1996) Studies on the processing of crude drugs(V). On the constituents and biological activities of Glycyrrhizae Radix by processing. Kor. J. Pharmacogn. 27: 196-206. 
    6. Shin, Y. W., Kim, D. H. and Kim, N. J. (2003) Studies on the processing of crude drugs(VII). On the constituents and biological activities of Gardeniae Fructus by processing. Kor. J. Pharmacogn. 34: 45-54. 
    7. 김남재 (1997) 한약의 수치와 약효. 병원약사회지, 14: 66-69. 
    8. Uchiyama, M., Suzuki, Y. and Fukuzawa, K. (1968) Biochemical studies of physiological function of tocopheronolactone. 1. Yakugaku Zasshi 88: 678-683. 
    9. Choi, J. S., Park, J. H. and Kim, H. G. (1993) Screening for antioxidant activity of plants and marine algae and its active principles from Prunus daviana. Kor. J. Pharmacogn. 24: 299-303. 
    10. Yoshikawa, M., Harada, E., Miki, A., Tsukamoto, K., Liang, S. Q., Yamahara, J. and Murakami, N. (1994) Antioxidant constituents from the fruit hulls of Mangosteen (Garcinia mangostana L.) originating in Vetnam. Yakugaku Zasshi 114: 129-133. 
    11. Li, L., Tsao, R., Liu, Z., Liu, S., Yang, R., Cristopher Young, J., Zhu, H., Deng, Z., Xie, M. and Fu, Z. (2005) Isolation and purification of acteoside and isoacteoside from Plantago psyllium L. by high-speed counter-current chromatography. J. Chromatogr. A 1063: 161-169. 
    12. Namba, T. (1994) The encyclopedia of Wakan-Yaku (Traditional Sino- Japanese Medicines) with color pictures. Vol. II. 16-17. Hoikusha, Osaka. 
    13. Wong, C. C., Li, H. B., Cheng, K. W. and Chen, F. (2006) A systematic survey of antioxidant activity of 30 Chinese medicinal plants using the ferric reducing antioxidant power assay. Food Chem. 97: 705-711. 
    14. 김남재 (1995) 한방약물의 약리작용. 병원약사회지 12: 121-138. 
    15. 강수영, 서부일, 최호영 (2003) 한약포제와 임상응용, 15-28. 영림사, 서울. 
    16. Kobayashi, H., Karasawa, H. and Miyase, T. (1984) Studies on the constituents of Cistanchis Herba. III. Isolation and structures of new phenylpropanoid glycosides, Cistanoside A and B. Chem. Pharm. Bull. 32: 3009-3014. 
    17. Kobayashi, H., Oguchi, H., Takizawa, N., Miyase, T.Ueno, A., Usmanghani, K. and Ahmad, M. (1987) New phenylethanoid glycosides from Cistanche tubulosa (Schrenk) Hook. F. I. Chem. Pharm. Bull. 35: 3309-3314. 
    18. Zong, G., He, W., Wu, G. L. and Chen, L. H. (1996) Comparisons between Cistanche deserticola Y. C. Ma and Cistanche tubulosa(Schrenk) Wight on some pharmacological activities. J. Tradit. Chin. Med. 21: 436-438. 
    19. Xiong, Q., Hase, K., Tezuka, Y., Tani, T., Namba, T. and Kadota, S. (1998) Hepatoprotective activity of phenylethanoids from Cistanche deserticola. Planta Med. 64: 120-125. 
    20. Lu, M. C. (1998) Studies on the sedative effect of Cistanche deserticola.. J. Ethnopharmacol. 59: 161-1655. 
    21. Cheng, X. Y., Wei, T., Guo, B., Ni, W. and Liu, C. Z. (2005) Cistanche deserticola cell suspension cultures: Phenylethanoid glycosides biosynthesis and antioxidant activity. Process Biochem. 40: 3119-3124. 
    22. Yoshizawa, F., Deyama, T., Takizawa, N., Usmanghani, K. and Ahmad, M. (1990) The constituents of Cistanche tubulosa (Schrenk) Hook. F. II. Isolation and structuers of a new phenylethanoid glycoside and a new neolignan glycoside. Chem. Pharm. Bull. 38: 1927-1930. 
    23. Munkombwe, N. M. (2003) Acetylated phenolic glycosides form Harpagophytum procumbens. Phytochemistry 62: 1231-1234. 
    24. Li, L., Tsao, R., Yang, R., Liu, C., Cristopher Young, J. and Zhu, H. (2008) Isolation and purification of phenylethanoid glycosides from Cistanche deserticola by high-speed counter chromatography. Food chem. 108: 702-710. 
    25. Owen, R. W., Haubner, R., Mier, W., Giacosa, A., Hull, W. E., Spiehelhaler, B. and Bartsch, H. (2003) Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined Olive drupes. Food Chem. Toxicol. 41: 703-717. 
    26. Wu, Y. T., Lin, L. C., Sung, J. S. and Tsai, T. H. (2006) Determination of acteoside in Cistanche deserticola and Boschniakia rossica and its pharmacokinetics in freely-moving rats using LC-MS/MS. J. Chromatogr. B 844: 89-95. 
    27. Yin, J. G., Yuan, C. S. and Jia, Z. J. (2007) A new iridoid and other chemical constituents from Pedicularis kansuensis forma albiflora Li. Arch. Pharm. Res. 30: 431-435. 
    28. Xiong, Q., Kadota, S., Tani, T. and Namba, T. (1996) Antioxidative effects of phenylethanoids from Cistanche deserticola. Biol. Pharm. Bull. 19: 1580-1585. 

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