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생약학회지 v.43 no.1 = no.168, 2012년, pp.66 - 71   피인용횟수: 6

엉겅퀴(Cirsium japonicum var. ussuriense) 잎 및 꽃 추출물이 정상인 적혈구와 혈장의 산화적 손상에 대한 보호효과
Protective Effects of Leaf and Flower Extracts from Cirsium japonicum var. ussuriense on Oxidative Damage in Normal Human Erythrocytes and Plasma

강현주    (임실생약조합   ); 목지예    (전주대학교 대체의학대학   ); 조정근    (전주대학교 방사선학과   ); 전인화    (전주대학교 대체의학대학   ); 김현수    (전주대학교 대체의학대학   ); 박지민    (전주대학교 대체의학대학   ); 정승일    (전주생물소재연구소   ); 심재석    (임실생약조합   ); 장선일    (전주대학교 대체의학대학  );
  • 초록

    Cirsium japonicum var. ussuriense is often used in treatment of human disease such as hemorrhage, blood congestion and inflammation. This study was accomplished to evaluate the antioxidant properties of the leaf (CLE) and flower (CFE) extracts of C. japonicum var. ussuriense to protect normal human red blood cells (RBC) and plasma samples against oxidative damage in vitro. CLE and CFE were prepared by extracting with hot water. In red blood cells and plasma, oxidative hemolysis and lipid peroxidation induced by the aqueous peroxyl radical generator [2,2'-azobis (2-amidinopropane) dihydrochloride, AAPH] were significantly suppressed by CLE or CFE in a dose-dependent manner at the same time. CLE and CFE also prevented the depletion of cytosolic antioxidant glutathione (GSH) in RBC. These results suggest that the leaves and flowers of C. japonicum var. ussuriense may have the antioxidant properties.


  • 주제어

    Cirsium japonicum var.   ussuriense .   Oxidative damage .   Antioxidant.  

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    1. Kang, Hyun Ju ; Kim, Hyeon Soo ; Jeon, In Hwa ; Mok, Ji Ye ; Jeong, Seung-Il ; Shim, Jae Suk ; Jang, Seon Il 2013. "Ameliorative Effect of the Water Extract from Cirsium japonicum var. ussuriense Leaves on Blood Circulation in a Rat Model of Topical Ferric Chloride-Induced Carotid Artery Damage" 생약학회지, 44(2): 131~137     
    2. Kang, Hyun Ju ; Kim, Hyeon Soo ; Jeon, In Hwa ; Mok, Ji Ye ; Jeong, Seung Il ; Shim, Jae Suk ; Jang, Seon Il 2013. "Suppressive Effect of Water Extract from Leaf of Cirsium japonicum var. ussuriense on Collagen-induced Arthritis" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 27(4): 416~421     
    3. Kang, Hyun Ju ; Kim, Hyeon Soo ; Jeon, In Hwa ; Mok, Ji Ye ; Han, Kyeong Soo ; Jang, Seon Il 2013. "Effects of Antioxidant and Blood Flow Improvement of Grape Leaf Extract and Resveratrol from Vitis romaneti" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 42(11): 1736~1743     
    4. Jeong, Seung-Il ; Kim, Hyeon Soo ; Jeon, In Hwa ; Kang, Hyun Ju ; Mok, Ji Ye ; Cheon, Chun Jin ; Yu, Hyeon Hee ; Jang, Seon Il 2014. "Antioxidant and Anti-inflammatory Effects of Ethanol Extracts from Perilla frutescens" 한국식품과학회지 = Korean journal of food science and technology, 46(1): 87~93     
    5. Jang, Ja-Young ; Lee, Jieun ; Choi, Eun-Ji ; Choi, Hak-Jong ; Oh, Young Jun ; Lee, Sung Hyun ; Kim, Hyun Ju 2015. "Effect of Starter Cultures on the Antioxidant Activities of Allium hookeri Root-Hot Water Extract" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 31(1): 98~102     
    6. Kang, Jeong Eun ; Park, Seon Kyeong ; Guo, Tian Jiao ; Kang, Jin Yong ; Lee, Du Sang ; Kim, Jong Min ; Kwon, O-Jun ; Lee, Uk ; Heo, Ho Jin 2016. "Antioxidant activity and comparative analysis of major functional compounds in liqueur using coffee and coffee-ground" 한국식품저장유통학회지 = Korean journal of food preservation, 23(4): 560~567     

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