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The journal of microbiology v.50 no.2, 2012년, pp.218 - 225   SCIE SCOPUS
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Microbial Fingerprinting Detects Unique Bacterial Communities in the Faecal Microbiota of Rats with Experimentally-Induced Colitis

Samanta, Ashis K.    (National Institute of Animal Nutrition and Physiology   ); Torok, Valeria A.    (South Australian Research and Development Institute, Plant and Soil Health, Waite Campus   ); Percy, Nigel J.    (South Australian Research and Development Institute, Plant and Soil Health, Waite Campus   ); Abimosleh, Suzanne M.    (Discipline of Physiology, School of Health Sciences, The University of Adelaide   ); Howarth, Gordon S.    (Gastroenterology Department, Women's and Children's Hospital  );
  • 초록

    An abnormal composition of the gut microbiota is believed to be associated with the pathogenesis of inflammatory bowel disease (IBD). We utilized terminal restriction fragment length polymorphism (T-RFLP) analysis to quantify faecal bacterial communities from rats with experimental colitis. Male Sprague Dawley rats (n=10/group) ingested 2% dextran sulfate sodium (DSS) or water for up to 7 days. Rats were killed and colonic tissues collected for histological analysis. Damage severity score in the distal colon was significantly greater (P


  • 주제어

    faecal bacterial profiling .   inflammatory bowel disease .   T-RFLP .   experimental colitis .   rat.  

  • 참고문헌 (50)

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