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The journal of microbiology v.50 no.2, 2012년, pp.359 - 362   SCIE SCOPUS 피인용횟수: 3
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GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents

Kim, Jin-Il    (Department of Microbiology, College of Medicine, Hallym University   ); Park, Se-Hee    (Department of Microbiology, College of Medicine, Hallym University   ); Lee, Il-Seob    (Department of Microbiology, College of Medicine, Hallym University   ); Lee, Sang-Moo    (Department of Microbiology, College of Medicine, Hallym University   ); Shin, Saem    (Department of Microbiology, College of Medicine, Hallym University   ); Won, Yong-Kwan    (Department of Microbiology, College of Medicine, Hallym University   ); Hwang, Min-Woong    (Department of Microbiology, College of Medicine, Hallym University   ); Bae, Joon-Yong    (Department of Microbiology, College of Medicine, Hallym University   ); Heo, Jun    (Department of Microbiology, College of Medicine, Hallym University   ); Hyun, Hye-Eun    (Department of Microbiology, College of Medicine, Hallym University   ); Jun, Hye-Jin    (Department of Microbiology, College of Medicine, Hallym University   ); Lim, Soon-Sung    (Department of Food Science and Nutrition, College of Natural Sciences, Hallym University   ); Park, Man-Seong    (Department of Microbiology, College of Medicine, Hallym University  );
  • 초록

    To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses.


  • 주제어

    influenza .   green fluorescent protein .   antiviral drug.  

  • 참고문헌 (15)

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    7. Kumar, P., Bartoszek, A.E., Moran, T.M., Gorski, J., Bhattacharyya, S., Navidad, J.F., Thakar, M.S., and Malarkannan, S. 2012. High-throughput detection method for influenza virus. J. Vis. Exp. doi: 10.3791/3623. 
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  • 이 논문을 인용한 문헌 (3)

    1. 2012. "" The journal of microbiology, 50(6): 1067~1070     
    2. 2016. "" Nutrition research and practice, 10(1): 3~10     
    3. 2016. "" The journal of microbiology, 54(10): 695~700     

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