본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Food science and biotechnology v.21 no.2, 2012년, pp.331 - 337   SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Ameliorative Effect of Saltwort (Salicornia herbacea) Extract on Hepatic Dysfunction and Hyperlipidemia in Rats

Park, Kap-Joo    (Department of Biological Sciences, Konkuk University   ); Cho, Myung-Hwan    (Department of Biological Sciences, Konkuk University   ); Kim, Soo-Young    (Department of Biological Sciences, Konkuk University   ); Lee, Jae-Seok    (Department of Biological Sciences, Konkuk University  );
  • 초록

    To examine the effect of saltwort (Salicornia herbacea) on blood cholesterol and lipid metabolism, hyperlipidemia was induced in animal rats. Saltwort extract was then administered to the rats for 5 weeks, after which, blood biochemical changes were determined. Saltwort treatment resulted in a significant reduction of the levels of total cholesterol, blood triglyceride, and LDL-cholesterol. In contrast, the expression levels of HDL-cholesterol were increased at saltwort treatment group. The aspartate aminotransferase (AST: serum SGOT) value of the saltwort administration group was significantly reduced and the blood alanine aminotransferase (ALT: serum SGPT) levels decreased significantly in comparison to those in the negative control group. Degeneration of hepatic tissues due to the consumption of a high lipid diet for a long period of time was reported in the negative control group. On the other hand, in the saltwort administration group, a substantial reduction in the accumulation of lipid droplets in the cytoplasm was seen, and in addition, it was confirmed that the degeneration of hepatic tissues recovered almost to level of that of the normal control group. These data suggest that saltwort extract represents an excellent candidate for protection of rat hepatocytes from high fat diet-mediated damage.


  • 주제어

    hyperlipidemia .   saltwort (Salicornia herbacea) .   rat liver cell .   lipid metabolism.  

  • 참고문헌 (23)

    1. Kim YA. Isolation and characterization of secondary metabolites from the salt marsh plant Salicornia herbacea L. PhD thesis, Korea Maritime University, Pusan, Korea (2005) 
    2. Greenway H, Munns R. Mechanism of salt tolerance in Ronhalophytes, Ann. Rev. Plant Physio. 83: 510-516 (1980) 
    3. Kim YS, Jeong YO, Park JC, Huh MR. Growth characteristics and mineral concentrations in glasswort as affected by NaCl concentration. J. Korean Plant. Human. Environ. 5: 239-247 (2002) 
    4. Lee JT, An BJ. Detection of physical activity of Salicornia herbacea L. Korean J. Herbol. 17: 61-69 (2002) 
    5. Rogers DJ, Loveless RW. Electron microscopy of human erythrocytes agglutinated by lectin from Codium fragile sp. tomentosoides and pseudohaemagglutinin from Ascophyllum nodosum. J. Appl. Phycol. 3: 83-86 (1991) 
    6. Korea National Statistical Office. Annual report of the cause of death statistics. Korea National Statistical Press, Seoul, Korea. pp. 2-5 (2008) 
    7. Mettson FH, Grundy SM. Comparison of effects of ditary saturated monounsaturated and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J. Lipid Res. 26: 194-200 (1985) 
    8. Kohomoto TF, Fukui H, Takaku Y, Machida T, Mitsuoka T. Effect of isomaltooligosaccharide on human fecal flora. Bifidobacteria Microflora 7: 61-67 (1988) 
    9. Han SK, Kim SM. Antioxidative effect of Salicornia herbacea L. grown in closed sea beach. J. Korean Soc. Food Sci. Nutr. 32: 207- 210 (2003)     
    10. Lee JT, Jeong YS, An BJ. Physiological activity of Salicornia herbacea L. and its application for cosmetic materials. Korean J. Herbol. 17: 51-60 (2002) 
    11. Cha JY, Jeon BS, Park JW, Kim BK, Jeong CY, Ryu JS, Choi CK, Cho YS. Hypocholesterolemic effect of yogurt supplemented Salicornia herbacea L. extract in cholesterol-fed rats. J. Life Sci. 14: 747-751 (2004) 
    12. Lee CH, Kim IH, Kim YE, Oh SW, LEE HJ. Determination of betaine from Salicornia herbacea L. J. Korean Soc. Food Sci. Nutr. 33: 1584-1587 (2004)     
    13. Kang SM, Shim JY, Hwang SJ, Hong SG, Jang HE, Park MH. Effect of saengshik supplementation on health improvement in dietinduced hypercholesterolemic rats. J. Korean Soc. Food Sci. Nutr. 32: 906-912 (2003)     
    14. Lee JS, Ahn KH, Park KJ. Ameliorative effects of pine needle oil on liver protection and lipid metabolism of alcohol-fed rats. Food Sci. Biotechnol. 14: 99-101 (2005) 
    15. Park KJ, Kim HY, Chang BJ, Lee HH. Ameliorative effects of soy 11s protein on liver damage and hyperlipidemia in alcohol-fed rats. Biol. Pharm. Bull. 27: 1636-1641 (2004) 
    16. Cho SH, Ha TY. In vitro and in vivo effects of prosomillet and sorghum on cholesterol metabolism. Food Sci. Biotechnol. 12: 485- 490 (2004) 
    17. Lee JS, Kim HY, Park KJ, Lee HH. Effects of soybean embryo on liver protection and lipid metabolism of alcohol-fed rats. Food Sci. Biotechnol. 14: 102-107 (2005) 
    18. Samuel P, McNanara DJ. Dfferential absorption of exogeneous and endogeneous cholesterol in man. J. Lipid Res. 24: 265-269 (1983) 
    19. Lim HJ, Chol KH, Cho RW. The effects of functional tea supplement with medical nutrition therapy on the blood lipid levels and antioxidant status in subjects with hyperlipidemia. J. Korean Soc. Food Sci. Nutr. 34: 42-56 (2005) 
    20. Kannel WB, Dawber TR, Frieman GD. Risk factor in coronary heart disease continous and grade; Primary screens of multiple risk factor intervention trial (MEFIT). J. Am. Med. Assoc. 256: 2853- 2870 (1964) 
    21. Goldstein JL, Brown MS. Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism. Am. J. Med. 58: 147-152 (1975) 
    22. Park KJ, Lee MJ, Kang H, Lee HH. A medicinal herb complex, protects liver cell damage induced by alcohol. Biol. Pharm. Bull. 25: 451-1455 (2002) 
    23. Park KJ, Hwang EK, Park CS, Lee JS. The effect of Codium fragile (Chlorophyta) extract on hepatic dysfunction and hyperlipidemia in rats. Korean J. Environ. Biol. 28: 79-85 (2010)     

 저자의 다른 논문

  • Park, Kap-Joo (19)

    1. 1993 "Bacillus thuringiensis 분리균의 증식과 내독소 생산" 산업미생물학회지 = Korean journal of applied microbiology and biotechnology 21 (3): 193~199    
    2. 1998 "Construction of a Baculovirus Expression System Using Hyphantria cunea Nuclear Polyhedrosis Virus for Eukaryotic Cells" Journal of microbiology and biotechnology 8 (6): 676~684    
    3. 1998 "Expression of Bovine Growth Hormone Gene in a Baculovirus, Hyphantria cunea Nuclear Polyhedrosis Virus" 대한바이러스학회지 = The journal of the Korean society of virology 28 (2): 129~138    
    4. 1999 "Vibrio parahemolyticus에 대한 한방처방 "방약합편(方藥合編)${\rfloor}$ 및 그 단미제의 항균활성에 관한 연구" 韓國韓醫學硏究院論文集 = Korean journal of oriental medicine 5 (1): 59~72    
    5. 2000 "Vibrio parahemolyticus에 대한 한방처방(금궤요략) 및 그 구성약재의 항균활성에 관한 연구" 韓國韓醫學硏究院論文集 = Korean journal of oriental medicine 6 (1): 107~116    
    6. 2000 "Expression of the HSV-1 (F) Glycoprotein B Gene in Insect Cells Infected by HcNPV Recombinant" Journal of microbiology and biotechnology 10 (3): 355~362    
    7. 2001 "Nursing Effects of Thiols Including Cysteine in Lymph Node Stromal Cells and P388 Cells" Journal of life science 11 (2): 99~102    
    8. 2003 "유자의 착즙방법별 착즙액의 특성 및 관능검사" 환경생물 = Korean journal of environmental biology 21 (1): 31~35    
    9. 2003 "Pine Needle Oil and Korean Medicinal Herb Complex Protect Hyperlipidemia and Liver Cell Damage Induced by Alcohol" 환경생물 = Korean journal of environmental biology 21 (4): 410~414    
    10. 2004 "Effects of Korean Citrus junos and Medicinal Herbs on Liver Protection and Lipid Metabolism of Alcohol Fed Rats" 환경생물 = Korean journal of environmental biology 22 (1): 141~147    
  • Cho, Myung-Hwan (15)

  • 김수영 (24)

  • Lee, Jae-Seok (19)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 이용한 콘텐츠
이 논문과 함께 출판된 논문 + 더보기